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Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.

Autefage H, Albinet V, Garcia V, Berges H, Nicolau ML, Therville N, Altié MF, Caillaud C, Levade T, Andrieu-Abadie N.

J Biol Chem. 2009 Apr 24;284(17):11507-16. doi: 10.1074/jbc.M807151200. Epub 2009 Feb 26.


Mannose 6-phosphorylated proteins are required for tumor necrosis factor-induced apoptosis: defective response in I-cell disease fibroblasts.

Tardy C, Autefage H, Garcia V, Levade T, Andrieu-Abadie N.

J Biol Chem. 2004 Dec 17;279(51):52914-23. Epub 2004 Sep 27.


Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

Harper N, Hughes MA, Farrow SN, Cohen GM, MacFarlane M.

J Biol Chem. 2003 Nov 7;278(45):44338-47. Epub 2003 Aug 14.


Aryl hydrocarbon receptor modulation of tumor necrosis factor-alpha-induced apoptosis and lysosomal disruption in a hepatoma model that is caspase-8-independent.

Caruso JA, Mathieu PA, Joiakim A, Zhang H, Reiners JJ Jr.

J Biol Chem. 2006 Apr 21;281(16):10954-67. Epub 2006 Jan 30.


Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route.

Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Bromme D, Krajewski S, Reed JC, Yin XM, Turk V, Salvesen GS.

J Biol Chem. 2001 Feb 2;276(5):3149-57. Epub 2000 Nov 9.


Tumor necrosis factor-related apoptosis inducing ligand (TRAIL)-induced apoptosis is dependent on activation of cysteine and serine proteases.

Park IC, Park MJ, Woo SH, Lee KH, Lee SH, Rhee CH, Hong SI.

Cytokine. 2001 Aug 7;15(3):166-70.


Bid is upstream of lysosome-mediated caspase 2 activation in tumor necrosis factor alpha-induced hepatocyte apoptosis.

Guicciardi ME, Bronk SF, Werneburg NW, Yin XM, Gores GJ.

Gastroenterology. 2005 Jul;129(1):269-84.


Biosynthesis, glycosylation, and enzymatic processing in vivo of human tripeptidyl-peptidase I.

Golabek AA, Kida E, Walus M, Wujek P, Mehta P, Wisniewski KE.

J Biol Chem. 2003 Feb 28;278(9):7135-45. Epub 2002 Dec 17.


Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins.

Cirman T, Oresić K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B.

J Biol Chem. 2004 Jan 30;279(5):3578-87. Epub 2003 Oct 27.

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