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Role of the microenvironment for radiosensitization by patupilone.

Bley CR, Jochum W, Orlowski K, Furmanova P, Vuong V, McSheehy PM, Pruschy M.

Clin Cancer Res. 2009 Feb 15;15(4):1335-42. doi: 10.1158/1078-0432.CCR-08-0969.


Patupilone acts as radiosensitizing agent in multidrug-resistant cancer cells in vitro and in vivo.

Hofstetter B, Vuong V, Broggini-Tenzer A, Bodis S, Ciernik IF, Fabbro D, Wartmann M, Folkers G, Pruschy M.

Clin Cancer Res. 2005 Feb 15;11(4):1588-96.


Regulation of VEGF-expression by patupilone and ionizing radiation in lung adenocarcinoma cells.

Rohrer Bley C, Orlowski K, Furmanova P, McSheehy PM, Pruschy M.

Lung Cancer. 2011 Sep;73(3):294-301. doi: 10.1016/j.lungcan.2011.01.010. Epub 2011 Feb 17.


The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.

Oehler C, von Bueren AO, Furmanova P, Broggini-Tenzer A, Orlowski K, Rutkowski S, Frei K, Grotzer MA, Pruschy M.

Neuro Oncol. 2011 Sep;13(9):1000-10. doi: 10.1093/neuonc/nor069. Epub 2011 Jul 9.


p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo.

Katiyar SK, Meeran SM, Katiyar N, Akhtar S.

Mol Carcinog. 2009 Jan;48(1):24-37. doi: 10.1002/mc.20453.


Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.

O'Reilly T, Wartmann M, Brueggen J, Allegrini PR, Floersheimer A, Maira M, McSheehy PM.

Cancer Chemother Pharmacol. 2008 Nov;62(6):1045-54. doi: 10.1007/s00280-008-0695-9. Epub 2008 Feb 27.


Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.

Lin B, Catley L, LeBlanc R, Mitsiades C, Burger R, Tai YT, Podar K, Wartmann M, Chauhan D, Griffin JD, Anderson KC.

Blood. 2005 Jan 1;105(1):350-7. Epub 2004 Sep 14.


Combined treatment strategies for microtubule stabilizing agent-resistant tumors.

Broggini-Tenzer A, Sharma A, Nytko KJ, Bender S, Vuong V, Orlowski K, Hug D, O'Reilly T, Pruschy M.

J Natl Cancer Inst. 2015 Feb 17;107(4). pii: dju504. doi: 10.1093/jnci/dju504. Print 2015 Apr.


The microtubule stabilizer patupilone counteracts ionizing radiation-induced matrix metalloproteinase activity and tumor cell invasion.

Furmanova-Hollenstein P, Broggini-Tenzer A, Eggel M, Millard AL, Pruschy M.

Radiat Oncol. 2013 Apr 30;8:105. doi: 10.1186/1748-717X-8-105.


Anti-alphav integrin monoclonal antibody intetumumab enhances the efficacy of radiation therapy and reduces metastasis of human cancer xenografts in nude rats.

Ning S, Tian J, Marshall DJ, Knox SJ.

Cancer Res. 2010 Oct 1;70(19):7591-9. doi: 10.1158/0008-5472.CAN-10-1639. Epub 2010 Sep 14.


Patupilone (epothilone B, EPO906) inhibits growth and metastasis of experimental prostate tumors in vivo.

O'Reilly T, McSheehy PM, Wenger F, Hattenberger M, Muller M, Vaxelaire J, Altmann KH, Wartmann M.

Prostate. 2005 Nov 1;65(3):231-40.


Hypoxia modulation and radiosensitization by the novel dual EGFR and VEGFR inhibitor AEE788 in spontaneous and related allograft tumor models.

Oehler-Jänne C, Jochum W, Riesterer O, Broggini-Tenzer A, Caravatti G, Vuong V, Pruschy M.

Mol Cancer Ther. 2007 Sep;6(9):2496-504.


Dynamics of tumor hypoxia in response to patupilone and ionizing radiation.

Orlowski K, Rohrer Bley C, Zimmermann M, Vuong V, Hug D, Soltermann A, Broggini-Tenzer A, Pruschy M.

PLoS One. 2012;7(12):e51476. doi: 10.1371/journal.pone.0051476. Epub 2012 Dec 10.


A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence.

Yang CP, Verdier-Pinard P, Wang F, Lippaine-Horvath E, He L, Li D, Höfle G, Ojima I, Orr GA, Horwitz SB.

Mol Cancer Ther. 2005 Jun;4(6):987-95.


Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice.

Lee I, Kalota A, Gewirtz AM, Shogen K.

Anticancer Res. 2007 Jan-Feb;27(1A):299-307.


Ionizing radiation antagonizes tumor hypoxia induced by antiangiogenic treatment.

Riesterer O, Honer M, Jochum W, Oehler C, Ametamey S, Pruschy M.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3518-24.


Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines.

Iwasa T, Okamoto I, Suzuki M, Nakahara T, Yamanaka K, Hatashita E, Yamada Y, Fukuoka M, Ono K, Nakagawa K.

Clin Cancer Res. 2008 Oct 15;14(20):6496-504. doi: 10.1158/1078-0432.CCR-08-0468.


Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma.

O'Reilly T, Wartmann M, Maira SM, Hattenberger M, Vaxelaire J, Muller M, Ferretti S, Buchdunger E, Altmann KH, McSheehy PM.

Cancer Chemother Pharmacol. 2005 Apr;55(4):307-17. Epub 2004 Oct 26.


[Combined effects of endostatin gene transfer and ionizing radiation on lung adenocarcinoma model of A549-cells].

Ling CH, Ji C, Chen YB, Fu JX, Zhou JY, Chen WC, Yang JC, Su LY.

Zhonghua Jie He He Hu Xi Za Zhi. 2004 Oct;27(10):683-6. Chinese.

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