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Items: 1 to 20 of 115

1.

Bidirectional transport of amino acids regulates mTOR and autophagy.

Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO.

Cell. 2009 Feb 6;136(3):521-34. doi: 10.1016/j.cell.2008.11.044.

2.

An amino acid shuffle activates mTORC1.

Cohen A, Hall MN.

Cell. 2009 Feb 6;136(3):399-400. doi: 10.1016/j.cell.2009.01.021.

3.

The general amino acid control pathway regulates mTOR and autophagy during serum/glutamine starvation.

Chen R, Zou Y, Mao D, Sun D, Gao G, Shi J, Liu X, Zhu C, Yang M, Ye W, Hao Q, Li R, Yu L.

J Cell Biol. 2014 Jul 21;206(2):173-82. doi: 10.1083/jcb.201403009.

4.

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

Hassanein M, Hoeksema MD, Shiota M, Qian J, Harris BK, Chen H, Clark JE, Alborn WE, Eisenberg R, Massion PP.

Clin Cancer Res. 2013 Feb 1;19(3):560-70. doi: 10.1158/1078-0432.CCR-12-2334. Epub 2012 Dec 4.

5.

Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.

Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D.

Blood. 2013 Nov 14;122(20):3521-32. doi: 10.1182/blood-2013-03-493163. Epub 2013 Sep 6.

6.

Targeting glutamine transport to suppress melanoma cell growth.

Wang Q, Beaumont KA, Otte NJ, Font J, Bailey CG, van Geldermalsen M, Sharp DM, Tiffen JC, Ryan RM, Jormakka M, Haass NK, Rasko JE, Holst J.

Int J Cancer. 2014 Sep 1;135(5):1060-71. doi: 10.1002/ijc.28749. Epub 2014 Feb 17.

7.

Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage.

Fumarola C, La Monica S, Guidotti GG.

J Cell Physiol. 2005 Jul;204(1):155-65.

PMID:
15605414
8.

Amino acids fuel T cell-mediated inflammation.

Poffenberger MC, Jones RG.

Immunity. 2014 May 15;40(5):635-7. doi: 10.1016/j.immuni.2014.04.017.

9.

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development.

Wang Q, Hardie RA, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, Sadowski MC, Balaban S, Schreuder M, Nagarajah R, Wong JJ, Metierre C, Pinello N, Otte NJ, Lehman ML, Gleave M, Nelson CC, Bailey CG, Ritchie W, Rasko JE, Holst J.

J Pathol. 2015 Jul;236(3):278-89. doi: 10.1002/path.4518. Epub 2015 Apr 7.

10.

Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.

Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC.

Immunity. 2014 May 15;40(5):692-705. doi: 10.1016/j.immuni.2014.04.007. Epub 2014 May 1.

11.

Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells.

Sakiyama T, Musch MW, Ropeleski MJ, Tsubouchi H, Chang EB.

Gastroenterology. 2009 Mar;136(3):924-32. doi: 10.1053/j.gastro.2008.12.002. Epub 2008 Dec 3.

13.

Isolation of hyperactive mutants of mammalian target of rapamycin.

Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, Mizushima N, Maeda T.

J Biol Chem. 2008 Nov 14;283(46):31861-70. doi: 10.1074/jbc.M801546200. Epub 2008 Sep 23.

14.

Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.

Schriever SC, Deutsch MJ, Adamski J, Roscher AA, Ensenauer R.

J Nutr Biochem. 2013 May;24(5):824-31. doi: 10.1016/j.jnutbio.2012.04.018. Epub 2012 Aug 13.

PMID:
22898570
15.

AMPK and mTOR in cellular energy homeostasis and drug targets.

Inoki K, Kim J, Guan KL.

Annu Rev Pharmacol Toxicol. 2012;52:381-400. doi: 10.1146/annurev-pharmtox-010611-134537. Epub 2011 Oct 17. Review.

PMID:
22017684
16.

ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.

Fuchs BC, Finger RE, Onan MC, Bode BP.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C55-63. Epub 2007 Feb 28.

17.

Metabolic regulation of osteoclast differentiation and function.

Indo Y, Takeshita S, Ishii KA, Hoshii T, Aburatani H, Hirao A, Ikeda K.

J Bone Miner Res. 2013 Nov;28(11):2392-9. doi: 10.1002/jbmr.1976.

18.

Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth.

Roos S, Jansson N, Palmberg I, Säljö K, Powell TL, Jansson T.

J Physiol. 2007 Jul 1;582(Pt 1):449-59. Epub 2007 Apr 26.

19.

Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.

Hassanein M, Qian J, Hoeksema MD, Wang J, Jacobovitz M, Ji X, Harris FT, Harris BK, Boyd KL, Chen H, Eisenberg R, Massion PP.

Int J Cancer. 2015 Oct 1;137(7):1587-97. doi: 10.1002/ijc.29535. Epub 2015 May 6.

20.

Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells.

Nakajo T, Yamatsuji T, Ban H, Shigemitsu K, Haisa M, Motoki T, Noma K, Nobuhisa T, Matsuoka J, Gunduz M, Yonezawa K, Tanaka N, Naomoto Y.

Biochem Biophys Res Commun. 2005 Jan 7;326(1):174-80.

PMID:
15567168
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