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Results: 1 to 20 of 114

1.

Modulation of DNA methylation by a sesquiterpene lactone parthenolide.

Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, Aimiuwu J, Pang J, Bhasin D, Neviani P, Fuchs JR, Plass C, Li PK, Li C, Huang TH, Wu LC, Rush L, Wang H, Perrotti D, Marcucci G, Chan KK.

J Pharmacol Exp Ther. 2009 May;329(2):505-14. doi: 10.1124/jpet.108.147934. Epub 2009 Feb 6.

PMID:
19201992
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.

Milutinovic S, Brown SE, Zhuang Q, Szyf M.

J Biol Chem. 2004 Jul 2;279(27):27915-27. Epub 2004 Apr 15.

PMID:
15087453
[PubMed - indexed for MEDLINE]
Free Article
3.

The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer.

Sweeney CJ, Mehrotra S, Sadaria MR, Kumar S, Shortle NH, Roman Y, Sheridan C, Campbell RA, Murry DJ, Badve S, Nakshatri H.

Mol Cancer Ther. 2005 Jun;4(6):1004-12.

PMID:
15956258
[PubMed - indexed for MEDLINE]
Free Article
4.

Sesquiterpene lactone parthenolide suppresses tumor growth in a xenograft model of renal cell carcinoma by inhibiting the activation of NF-kappaB.

Oka D, Nishimura K, Shiba M, Nakai Y, Arai Y, Nakayama M, Takayama H, Inoue H, Okuyama A, Nonomura N.

Int J Cancer. 2007 Jun 15;120(12):2576-81.

PMID:
17290398
[PubMed - indexed for MEDLINE]
5.

Paclitaxel efficacy is increased by parthenolide via nuclear factor-kappaB pathways in in vitro and in vivo human non-small cell lung cancer models.

Gao ZW, Zhang DL, Guo CB.

Curr Cancer Drug Targets. 2010 Nov;10(7):705-15.

PMID:
20578985
[PubMed - indexed for MEDLINE]
6.

Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells.

Estève PO, Chin HG, Pradhan S.

J Biol Chem. 2007 Jan 26;282(4):2615-25. Epub 2006 Nov 22.

PMID:
17124180
[PubMed - indexed for MEDLINE]
Free Article
7.

Sesquiterpene lactone parthenolide markedly enhances sensitivity of human A549 cells to low-dose oxaliplatin via inhibition of NF-kappaB activation and induction of apoptosis.

Fang LJ, Shao XT, Wang S, Lu GH, Xu T, Zhou JY.

Planta Med. 2010 Feb;76(3):258-64. doi: 10.1055/s-0029-1186083. Epub 2009 Sep 11.

PMID:
19774508
[PubMed - indexed for MEDLINE]
8.

Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.

Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, He X, Liu S, Grever MR, Chan KK, Liu Z.

PLoS One. 2013;8(2):e55934. doi: 10.1371/journal.pone.0055934. Epub 2013 Feb 13.

PMID:
23457487
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer.

Singh V, Sharma P, Capalash N.

Curr Cancer Drug Targets. 2013 May;13(4):379-99. Review.

PMID:
23517596
[PubMed - indexed for MEDLINE]
10.

Dehydrocostuslactone disrupts signal transducers and activators of transcription 3 through up-regulation of suppressor of cytokine signaling in breast cancer cells.

Kuo PL, Ni WC, Tsai EM, Hsu YL.

Mol Cancer Ther. 2009 May;8(5):1328-39. doi: 10.1158/1535-7163.MCT-08-0914. Epub 2009 Apr 21.

PMID:
19383849
[PubMed - indexed for MEDLINE]
Free Article
11.

Parthenolide, an NF-κB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer.

Sohma I, Fujiwara Y, Sugita Y, Yoshioka A, Shirakawa M, Moon JH, Takiguchi S, Miyata H, Yamasaki M, Mori M, Doki Y.

Cancer Genomics Proteomics. 2011 Jan-Feb;8(1):39-47.

PMID:
21289336
[PubMed - indexed for MEDLINE]
12.

Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6)--a new compound with α-methylene-γ-lactone motif--on two breast cancer cell lines.

Wyrębska A, Gach K, Szemraj J, Szewczyk K, Hrabec E, Koszuk J, Janecki T, Janecka A.

Chem Biol Drug Des. 2012 Jan;79(1):112-20. doi: 10.1111/j.1747-0285.2011.01257.x. Epub 2011 Nov 4.

PMID:
21992414
[PubMed - indexed for MEDLINE]
13.

Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells.

Kishida Y, Yoshikawa H, Myoui A.

Clin Cancer Res. 2007 Jan 1;13(1):59-67.

PMID:
17200339
[PubMed - indexed for MEDLINE]
Free Article
14.

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.

Liu S, Liu Z, Xie Z, Pang J, Yu J, Lehmann E, Huynh L, Vukosavljevic T, Takeki M, Klisovic RB, Baiocchi RA, Blum W, Porcu P, Garzon R, Byrd JC, Perrotti D, Caligiuri MA, Chan KK, Wu LC, Marcucci G.

Blood. 2008 Feb 15;111(4):2364-73. Epub 2007 Dec 14.

PMID:
18083845
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Inhibition of tumor promotion by parthenolide: epigenetic modulation of p21.

Ghantous A, Saikali M, Rau T, Gali-Muhtasib H, Schneider-Stock R, Darwiche N.

Cancer Prev Res (Phila). 2012 Nov;5(11):1298-309. doi: 10.1158/1940-6207.CAPR-12-0230. Epub 2012 Oct 4.

PMID:
23037503
[PubMed - indexed for MEDLINE]
16.

Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.

Xie Q, Bai Q, Zou LY, Zhang QY, Zhou Y, Chang H, Yi L, Zhu JD, Mi MT.

Genes Chromosomes Cancer. 2014 May;53(5):422-31. doi: 10.1002/gcc.22154. Epub 2014 Feb 16.

PMID:
24532317
[PubMed - indexed for MEDLINE]
17.
18.

Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

Fang MZ, Wang Y, Ai N, Hou Z, Sun Y, Lu H, Welsh W, Yang CS.

Cancer Res. 2003 Nov 15;63(22):7563-70.

PMID:
14633667
[PubMed - indexed for MEDLINE]
Free Article
19.

Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.

Lubecka-Pietruszewska K, Kaufman-Szymczyk A, Stefanska B, Cebula-Obrzut B, Smolewski P, Fabianowska-Majewska K.

Eur J Pharmacol. 2014 Jan 15;723:276-87. doi: 10.1016/j.ejphar.2013.11.021. Epub 2013 Dec 1.

PMID:
24296317
[PubMed - indexed for MEDLINE]
20.

Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest.

Ralstin MC, Gage EA, Yip-Schneider MT, Klein PJ, Wiebke EA, Schmidt CM.

Mol Cancer Res. 2006 Jun;4(6):387-99.

PMID:
16778086
[PubMed - indexed for MEDLINE]
Free Article
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