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Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

Hunter DJ, Gerstenfeld L, Bishop G, Davis AD, Mason ZD, Einhorn TA, Maciewicz RA, Newham P, Foster M, Jackson S, Morgan EF.

Arthritis Res Ther. 2009;11(1):R11. doi: 10.1186/ar2601. Epub 2009 Jan 26.


Bone marrow lesions are associated with altered trabecular morphometry.

Driban JB, Tassinari A, Lo GH, Price LL, Schneider E, Lynch JA, Eaton CB, McAlindon TE; OAI Investigators Group.

Osteoarthritis Cartilage. 2012 Dec;20(12):1519-26. doi: 10.1016/j.joca.2012.08.013. Epub 2012 Aug 30.


Bone marrow lesion volume reduction is not associated with improvement of other periarticular bone measures: data from the Osteoarthritis Initiative.

Driban JB, Lo GH, Price L, Pang J, Miller E, Ward RJ, Hunter DJ, Eaton CB, Lynch JA, McAlindon TE; OAI Investigators Group.

Arthritis Res Ther. 2013;15(5):R153.


A study of the prevalence and associations of subchondral bone marrow lesions in the knees of healthy, middle-aged women.

Guymer E, Baranyay F, Wluka AE, Hanna F, Bell RJ, Davis SR, Wang Y, Cicuttini FM.

Osteoarthritis Cartilage. 2007 Dec;15(12):1437-42. Epub 2007 Jun 7.


Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults.

Dore D, Martens A, Quinn S, Ding C, Winzenberg T, Zhai G, Pelletier JP, Martel-Pelletier J, Abram F, Cicuttini F, Jones G.

Arthritis Res Ther. 2010;12(6):R222. doi: 10.1186/ar3209. Epub 2010 Dec 29.


Bone marrow lesions identified by MRI in knee osteoarthritis are associated with locally increased bone mineral density measured by QCT.

Lowitz T, Museyko O, Bousson V, Laouisset L, Kalender WA, Laredo JD, Engelke K.

Osteoarthritis Cartilage. 2013 Jul;21(7):957-64. doi: 10.1016/j.joca.2013.04.006. Epub 2013 Apr 18.


Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study.

Roemer FW, Neogi T, Nevitt MC, Felson DT, Zhu Y, Zhang Y, Lynch JA, Javaid MK, Crema MD, Torner J, Lewis CE, Guermazi A.

Osteoarthritis Cartilage. 2010 Jan;18(1):47-53. doi: 10.1016/j.joca.2009.08.018. Epub 2009 Sep 10.


Osteoporotic changes of subchondral trabecular bone in osteoarthritis of the knee: a 3-T MRI study.

Chiba K, Uetani M, Kido Y, Ito M, Okazaki N, Taguchi K, Shindo H.

Osteoporos Int. 2012 Feb;23(2):589-97. doi: 10.1007/s00198-011-1585-2. Epub 2011 Feb 26.


Quantitative bone marrow lesion size in osteoarthritic knees correlates with cartilage damage and predicts longitudinal cartilage loss.

Driban JB, Lo GH, Lee JY, Ward RJ, Miller E, Pang J, Price LL, McAlindon TE.

BMC Musculoskelet Disord. 2011 Sep 30;12:217. doi: 10.1186/1471-2474-12-217.


Biochemical markers of bone turnover and their association with bone marrow lesions.

Hunter DJ, Lavalley M, Li J, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Totterman S, Felson DT.

Arthritis Res Ther. 2008;10(4):R102. doi: 10.1186/ar2494. Epub 2008 Aug 29.


An in vivo investigation of the initiation and progression of subchondral cysts in a rodent model of secondary osteoarthritis.

McErlain DD, Ulici V, Darling M, Gati JS, Pitelka V, Beier F, Holdsworth DW.

Arthritis Res Ther. 2012 Feb 3;14(1):R26. doi: 10.1186/ar3727.


The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study.

Tanamas SK, Wluka AE, Pelletier JP, Martel-Pelletier J, Abram F, Wang Y, Cicuttini FM.

Arthritis Res Ther. 2010;12(2):R58. doi: 10.1186/ar2971. Epub 2010 Mar 31.


Association of bone marrow lesions with knee structures and risk factors for bone marrow lesions in the knees of clinically healthy, community-based adults.

Baranyay FJ, Wang Y, Wluka AE, English DR, Giles GG, Sullivan RO, Cicuttini FM.

Semin Arthritis Rheum. 2007 Oct;37(2):112-8. Epub 2007 Mar 27.


Knee malalignment is associated with an increased risk for incident and enlarging bone marrow lesions in the more loaded compartments: the MOST study.

Hayashi D, Englund M, Roemer FW, Niu J, Sharma L, Felson DT, Crema MD, Marra MD, Segal NA, Lewis CE, Nevitt MC, Guermazi A.

Osteoarthritis Cartilage. 2012 Nov;20(11):1227-33. doi: 10.1016/j.joca.2012.07.020. Epub 2012 Aug 5.


Tibial subchondral trabecular volumetric bone density in medial knee joint osteoarthritis using peripheral quantitative computed tomography technology.

Bennell KL, Creaby MW, Wrigley TV, Hunter DJ.

Arthritis Rheum. 2008 Sep;58(9):2776-85. doi: 10.1002/art.23795.


Development of bone marrow lesions is associated with adverse effects on knee cartilage while resolution is associated with improvement--a potential target for prevention of knee osteoarthritis: a longitudinal study.

Davies-Tuck ML, Wluka AE, Forbes A, Wang Y, English DR, Giles GG, O'Sullivan R, Cicuttini FM.

Arthritis Res Ther. 2010;12(1):R10. doi: 10.1186/ar2911. Epub 2010 Jan 19.


Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker--longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative.

Driban JB, Price L, Lo GH, Pang J, Hunter DJ, Miller E, Ward RJ, Eaton CB, Lynch JA, McAlindon TE.

Arthritis Res Ther. 2013;15(5):R112.


A rapid, novel method of volumetric assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis.

Ratzlaff C, Guermazi A, Collins J, Katz JN, Losina E, Vanwyngaarden C, Russell R, Iranpour T, Duryea J.

Osteoarthritis Cartilage. 2013 Jun;21(6):806-14. doi: 10.1016/j.joca.2013.03.007. Epub 2013 Mar 18.


[Histomorphometric analysis of articular cartilage and subchondral bone from primary osteoarthritic knees].

Song W, Yang L, Wang F.

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011 Dec;25(12):1434-9. Chinese.


Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST Study.

Englund M, Guermazi A, Roemer FW, Yang M, Zhang Y, Nevitt MC, Lynch JA, Lewis CE, Torner J, Felson DT.

Ann Rheum Dis. 2010 Oct;69(10):1796-802. doi: 10.1136/ard.2009.121681. Epub 2010 Apr 26.

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