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Items: 1 to 20 of 97


An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.

Mintz PJ, Cardó-Vila M, Ozawa MG, Hajitou A, Rangel R, Guzman-Rojas L, Christianson DR, Arap MA, Giordano RJ, Souza GR, Easley J, Salameh A, Oliviero S, Brentani RR, Koivunen E, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2182-7. doi: 10.1073/pnas.0807543105. Epub 2009 Jan 23.


Modeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug design.

Panigrahi S, Stetefeld J, Jangamreddy JR, Mandal S, Mandal SK, Los M.

PLoS One. 2012;7(1):e28395. doi: 10.1371/journal.pone.0028395. Epub 2012 Jan 10.


Structural and functional basis of a role for CRKL in a fibroblast growth factor 8-induced feed-forward loop.

Seo JH, Suenaga A, Hatakeyama M, Taiji M, Imamoto A.

Mol Cell Biol. 2009 Jun;29(11):3076-87. doi: 10.1128/MCB.01686-08. Epub 2009 Mar 23.


p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene.

Salgia R, Pisick E, Sattler M, Li JL, Uemura N, Wong WK, Burky SA, Hirai H, Chen LB, Griffin JD.

J Biol Chem. 1996 Oct 11;271(41):25198-203.


Structural requirements for function of the Crkl adapter protein in fibroblasts and hematopoietic cells.

Senechal K, Heaney C, Druker B, Sawyers CL.

Mol Cell Biol. 1998 Sep;18(9):5082-90.


The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal.

Harkiolaki M, Gilbert RJ, Jones EY, Feller SM.

Structure. 2006 Dec;14(12):1741-53.


CrkL activates integrin-mediated hematopoietic cell adhesion through the guanine nucleotide exchange factor C3G.

Arai A, Nosaka Y, Kohsaka H, Miyasaka N, Miura O.

Blood. 1999 Jun 1;93(11):3713-22.


Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1).

Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD.

J Biol Chem. 1997 May 30;272(22):14320-6.


Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites.

Spurkland A, Brinchmann JE, Markussen G, Pedeutour F, Munthe E, Lea T, Vartdal F, Aasheim HC.

J Biol Chem. 1998 Feb 20;273(8):4539-46.


Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1.

Richard S, Yu D, Blumer KJ, Hausladen D, Olszowy MW, Connelly PA, Shaw AS.

Mol Cell Biol. 1995 Jan;15(1):186-97.


GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28.

Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA.

J Immunol. 2000 Jun 1;164(11):5805-14.


CRKL plays a pivotal role in tumorigenesis of head and neck squamous cell carcinoma through the regulation of cell adhesion.

Yanagi H, Wang L, Nishihara H, Kimura T, Tanino M, Yanagi T, Fukuda S, Tanaka S.

Biochem Biophys Res Commun. 2012 Feb 3;418(1):104-9. doi: 10.1016/j.bbrc.2011.12.142. Epub 2012 Jan 5.


CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O.

J Biol Chem. 2001 Aug 31;276(35):33282-90. Epub 2001 Jul 6.


The adapter protein CrkL associates with CD34.

Felschow DM, McVeigh ML, Hoehn GT, Civin CI, Fackler MJ.

Blood. 2001 Jun 15;97(12):3768-75.

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