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Results: 1 to 20 of 167

1.

The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: implications for leukemogenesis.

Birtwistle J, Hayden RE, Khanim FL, Green RM, Pearce C, Davies NJ, Wake N, Schrewe H, Ride JP, Chipman JK, Bunce CM.

Mutat Res. 2009 Mar 9;662(1-2):67-74. doi: 10.1016/j.mrfmmm.2008.12.010. Epub 2008 Dec 31.

PMID:
19162045
[PubMed - indexed for MEDLINE]
2.

The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

Desmond JC, Mountford JC, Drayson MT, Walker EA, Hewison M, Ride JP, Luong QT, Hayden RE, Vanin EF, Bunce CM.

Cancer Res. 2003 Jan 15;63(2):505-12.

PMID:
12543809
[PubMed - indexed for MEDLINE]
Free Article
3.

The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3.

Guise CP, Abbattista MR, Singleton RS, Holford SD, Connolly J, Dachs GU, Fox SB, Pollock R, Harvey J, Guilford P, Doñate F, Wilson WR, Patterson AV.

Cancer Res. 2010 Feb 15;70(4):1573-84. doi: 10.1158/0008-5472.CAN-09-3237. Epub 2010 Feb 9.

PMID:
20145130
[PubMed - indexed for MEDLINE]
Free Article
4.

AKR1C2 and AKR1C3 mediated prostaglandin D2 metabolism augments the PI3K/Akt proliferative signaling pathway in human prostate cancer cells.

Wang S, Yang Q, Fung KM, Lin HK.

Mol Cell Endocrinol. 2008 Jul 16;289(1-2):60-6. doi: 10.1016/j.mce.2008.04.004. Epub 2008 Apr 22.

PMID:
18508192
[PubMed - indexed for MEDLINE]
5.

Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma.

Fung KM, Samara EN, Wong C, Metwalli A, Krlin R, Bane B, Liu CZ, Yang JT, Pitha JV, Culkin DJ, Kropp BP, Penning TM, Lin HK.

Endocr Relat Cancer. 2006 Mar;13(1):169-80.

PMID:
16601286
[PubMed - indexed for MEDLINE]
Free Article
6.

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.

Penning TM, Steckelbroeck S, Bauman DR, Miller MW, Jin Y, Peehl DM, Fung KM, Lin HK.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):182-91. Epub 2006 Jan 18.

PMID:
16417966
[PubMed - indexed for MEDLINE]
7.

Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia.

Liu CY, Hsu YH, Pan PC, Wu MT, Ho CK, Su L, Xu X, Li Y, Christiani DC; Kaohsiung Leukemia Research Group.

Carcinogenesis. 2008 May;29(5):984-90. doi: 10.1093/carcin/bgn071. Epub 2008 Mar 13.

PMID:
18339682
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.

Palackal NT, Lee SH, Harvey RG, Blair IA, Penning TM.

J Biol Chem. 2002 Jul 5;277(27):24799-808. Epub 2002 Apr 26.

PMID:
11978787
[PubMed - indexed for MEDLINE]
Free Article
9.

Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells.

Matsunaga T, Arakaki M, Kamiya T, Endo S, El-Kabbani O, Hara A.

Chem Biol Interact. 2009 Sep 14;181(1):52-60. doi: 10.1016/j.cbi.2009.05.005. Epub 2009 May 13.

PMID:
19442656
[PubMed - indexed for MEDLINE]
10.

Aldo-keto reductase 1C3 may be a new radioresistance marker in non-small-cell lung cancer.

Xie L, Yu J, Guo W, Wei L, Liu Y, Wang X, Song X.

Cancer Gene Ther. 2013 Apr;20(4):260-6. doi: 10.1038/cgt.2013.15. Epub 2013 Mar 22.

PMID:
23519145
[PubMed - indexed for MEDLINE]
11.

Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis.

Mantel A, Carpenter-Mendini AB, Vanbuskirk JB, De Benedetto A, Beck LA, Pentland AP.

J Invest Dermatol. 2012 Apr;132(4):1103-10. doi: 10.1038/jid.2011.412. Epub 2011 Dec 15.

PMID:
22170488
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.

Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S.

J Biochem. 1998 Nov;124(5):940-6.

PMID:
9792917
[PubMed - indexed for MEDLINE]
Free Article
13.

Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions.

Lan Q, Mumford JL, Shen M, Demarini DM, Bonner MR, He X, Yeager M, Welch R, Chanock S, Tian L, Chapman RS, Zheng T, Keohavong P, Caporaso N, Rothman N.

Carcinogenesis. 2004 Nov;25(11):2177-81. Epub 2004 Jul 29.

PMID:
15284179
[PubMed - indexed for MEDLINE]
Free Article
14.

Toxic effects of methylated benz[a]anthracenes in liver cells.

Marvanová S, Vondrácek J, Penccíková K, Trilecová L, Krcmárr P, Topinka J, Nováková Z, Milcová A, Machala M.

Chem Res Toxicol. 2008 Feb;21(2):503-12. doi: 10.1021/tx700305x. Epub 2008 Jan 19.

PMID:
18205319
[PubMed - indexed for MEDLINE]
15.

Paracrine-stimulated gene expression profile favors estradiol production in breast tumors.

Amin SA, Huang CC, Reierstad S, Lin Z, Arbieva Z, Wiley E, Saborian H, Haynes B, Cotterill H, Dowsett M, Bulun SE.

Mol Cell Endocrinol. 2006 Jul 11;253(1-2):44-55. Epub 2006 Jun 2.

PMID:
16735089
[PubMed - indexed for MEDLINE]
16.

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

Davies NJ, Hayden RE, Simpson PJ, Birtwistle J, Mayer K, Ride JP, Bunce CM.

Cancer Res. 2009 Jun 1;69(11):4769-75. doi: 10.1158/0008-5472.CAN-08-4533.

PMID:
19487289
[PubMed - indexed for MEDLINE]
Free Article
17.

A novel fluorometric assay for aldo-keto reductase 1C3 predicts metabolic activation of the nitrogen mustard prodrug PR-104A in human leukaemia cells.

Jamieson SM, Gu Y, Manesh DM, El-Hoss J, Jing D, Mackenzie KL, Guise CP, Foehrenbacher A, Pullen SM, Benito J, Smaill JB, Patterson AV, Mulaw MA, Konopleva M, Bohlander SK, Lock RB, Wilson WR.

Biochem Pharmacol. 2014 Mar 1;88(1):36-45. doi: 10.1016/j.bcp.2013.12.019. Epub 2014 Jan 13.

PMID:
24434189
[PubMed - indexed for MEDLINE]
18.

Clinical implications of aldo-keto reductase family 1 member C3 and its relationship with lipocalin 2 in cancer of the uterine cervix.

Wu CH, Ko JL, Chen SC, Lin YW, Han CP, Yang TY, Chien MH, Wang PH.

Gynecol Oncol. 2014 Feb;132(2):474-82. doi: 10.1016/j.ygyno.2013.11.032. Epub 2013 Dec 4.

PMID:
24316309
[PubMed - indexed for MEDLINE]
19.

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

Byrns MC, Duan L, Lee SH, Blair IA, Penning TM.

J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):177-87. doi: 10.1016/j.jsbmb.2009.12.009. Epub 2009 Dec 28.

PMID:
20036328
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Imaging induction of cytoprotective enzymes in intact human cells: coumberone, a metabolic reporter for human AKR1C enzymes reveals activation by panaxytriol, an active component of red ginseng.

Halim M, Yee DJ, Sames D.

J Am Chem Soc. 2008 Oct 29;130(43):14123-8. doi: 10.1021/ja801245y. Epub 2008 Oct 1.

PMID:
18826220
[PubMed - indexed for MEDLINE]

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