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Results: 1 to 20 of 255

1.

Sodium channel inhibitor drug discovery using automated high throughput electrophysiology platforms.

Castle N, Printzenhoff D, Zellmer S, Antonio B, Wickenden A, Silvia C.

Comb Chem High Throughput Screen. 2009 Jan;12(1):107-22. Review.

PMID:
19149496
[PubMed - indexed for MEDLINE]
2.

Automated planar electrode electrophysiology in drug discovery: examples of the use of QPatch in basic characterization and high content screening on Na(v), K(Ca)2.3, and K(v)11.1 channels.

Korsgaard MP, Strøbaek D, Christophersen P.

Comb Chem High Throughput Screen. 2009 Jan;12(1):51-63. Review.

PMID:
19149491
[PubMed - indexed for MEDLINE]
3.

An ion channel library for drug discovery and safety screening on automated platforms.

Wible BA, Kuryshev YA, Smith SS, Liu Z, Brown AM.

Assay Drug Dev Technol. 2008 Dec;6(6):765-80. doi: 10.1089/adt.2008.0171.

PMID:
19090691
[PubMed - indexed for MEDLINE]
4.

High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology.

Dunlop J, Bowlby M, Peri R, Vasilyev D, Arias R.

Nat Rev Drug Discov. 2008 Apr;7(4):358-68. doi: 10.1038/nrd2552. Review.

PMID:
18356919
[PubMed - indexed for MEDLINE]
5.

Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology.

Farre C, Haythornthwaite A, Haarmann C, Stoelzle S, Kreir M, George M, Brüggemann A, Fertig N.

Comb Chem High Throughput Screen. 2009 Jan;12(1):24-37. Review.

PMID:
19149489
[PubMed - indexed for MEDLINE]
6.

Automated electrophysiology in drug discovery.

Priest BT, Swensen AM, McManus OB.

Curr Pharm Des. 2007;13(23):2325-37. Review.

PMID:
17692004
[PubMed - indexed for MEDLINE]
7.

Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery.

Asmild M, Oswald N, Krzywkowski KM, Friis S, Jacobsen RB, Reuter D, Taboryski R, Kutchinsky J, Vestergaard RK, Schrøder RL, Sørensen CB, Bech M, Korsgaard MP, Willumsen NJ.

Receptors Channels. 2003;9(1):49-58.

PMID:
12825298
[PubMed - indexed for MEDLINE]
8.

Use of planar array electrophysiology for the development of robust ion channel cell lines.

Clare JJ, Chen MX, Downie DL, Trezise DJ, Powell AJ.

Comb Chem High Throughput Screen. 2009 Jan;12(1):96-106.

PMID:
19149495
[PubMed - indexed for MEDLINE]
9.

QPatch: the missing link between HTS and ion channel drug discovery.

Mathes C, Friis S, Finley M, Liu Y.

Comb Chem High Throughput Screen. 2009 Jan;12(1):78-95. Review.

PMID:
19149494
[PubMed - indexed for MEDLINE]
10.

Automated voltage-clamp technique.

Ghetti A, Guia A, Xu J.

Methods Mol Biol. 2007;403:59-69. doi: 10.1007/978-1-59745-529-9_4.

PMID:
18827987
[PubMed - indexed for MEDLINE]
11.

Cellular HTS assays for pharmacological characterization of Na(V)1.7 modulators.

Trivedi S, Dekermendjian K, Julien R, Huang J, Lund PE, Krupp J, Kronqvist R, Larsson O, Bostwick R.

Assay Drug Dev Technol. 2008 Apr;6(2):167-79.

PMID:
18078380
[PubMed - indexed for MEDLINE]
12.

Exploiting high-throughput ion channel screening technologies in integrated drug discovery.

Treherne JM.

Curr Pharm Des. 2006;12(4):397-406. Review.

PMID:
16472135
[PubMed - indexed for MEDLINE]
13.

Targeting ion channels for drug discovery.

Clare JJ.

Discov Med. 2010 Mar;9(46):253-60. Review.

PMID:
20350493
[PubMed - indexed for MEDLINE]
Free Article
14.

Planar patch clamp: advances in electrophysiology.

Brüggemann A, Farre C, Haarmann C, Haythornthwaite A, Kreir M, Stoelzle S, George M, Fertig N.

Methods Mol Biol. 2008;491:165-76. doi: 10.1007/978-1-59745-526-8_13.

PMID:
18998092
[PubMed - indexed for MEDLINE]
15.

Automated ion channel screening: patch clamping made easy.

Farre C, Stoelzle S, Haarmann C, George M, Brüggemann A, Fertig N.

Expert Opin Ther Targets. 2007 Apr;11(4):557-65.

PMID:
17373884
[PubMed - indexed for MEDLINE]
16.

Novel trends in high-throughput screening.

Mayr LM, Bojanic D.

Curr Opin Pharmacol. 2009 Oct;9(5):580-8. doi: 10.1016/j.coph.2009.08.004. Epub 2009 Sep 21. Review.

PMID:
19775937
[PubMed - indexed for MEDLINE]
17.

Ion channel pharmacology under flow: automation via well-plate microfluidics.

Spencer CI, Li N, Chen Q, Johnson J, Nevill T, Kammonen J, Ionescu-Zanetti C.

Assay Drug Dev Technol. 2012 Aug;10(4):313-24. doi: 10.1089/adt.2011.414. Epub 2012 May 10.

PMID:
22574656
[PubMed - indexed for MEDLINE]
18.

Ionworks HT: a new high-throughput electrophysiology measurement platform.

Schroeder K, Neagle B, Trezise DJ, Worley J.

J Biomol Screen. 2003 Feb;8(1):50-64.

PMID:
12854998
[PubMed - indexed for MEDLINE]
19.

High throughput electrophysiology using a fully automated, multiplexed recording system.

Trumbull JD, Maslana ES, McKenna DG, Nemcek TA, Niforatos W, Pan JY, Parihar AS, Shieh CC, Wilkins JA, Briggs CA, Bertrand D.

Receptors Channels. 2003;9(1):19-28.

PMID:
12825295
[PubMed - indexed for MEDLINE]
20.

Potassium channels: gene family, therapeutic relevance, high-throughput screening technologies and drug discovery.

Ford JW, Stevens EB, Treherne JM, Packer J, Bushfield M.

Prog Drug Res. 2002;58:133-68. Review.

PMID:
12079199
[PubMed - indexed for MEDLINE]
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