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Results: 1 to 20 of 60

1.

Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.

Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P.

J Comb Chem. 2009 Mar 9;11(2):303-9. doi: 10.1021/cc8001525.

PMID:
19146410
[PubMed - indexed for MEDLINE]
2.

Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.

Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P.

Bioorg Med Chem. 2008 Nov 1;16(21):9596-602. doi: 10.1016/j.bmc.2008.09.025. Epub 2008 Sep 12.

PMID:
18835181
[PubMed - indexed for MEDLINE]
3.

Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271.

Roberts WG, Ung E, Whalen P, Cooper B, Hulford C, Autry C, Richter D, Emerson E, Lin J, Kath J, Coleman K, Yao L, Martinez-Alsina L, Lorenzen M, Berliner M, Luzzio M, Patel N, Schmitt E, LaGreca S, Jani J, Wessel M, Marr E, Griffor M, Vajdos F.

Cancer Res. 2008 Mar 15;68(6):1935-44. doi: 10.1158/0008-5472.CAN-07-5155.

PMID:
18339875
[PubMed - indexed for MEDLINE]
Free Article
4.

Cellular characterization of a novel focal adhesion kinase inhibitor.

Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT.

J Biol Chem. 2007 May 18;282(20):14845-52. Epub 2007 Mar 28.

PMID:
17395594
[PubMed - indexed for MEDLINE]
Free Article
5.

Signal transduction by focal adhesion kinase in cancer.

Zhao J, Guan JL.

Cancer Metastasis Rev. 2009 Jun;28(1-2):35-49. doi: 10.1007/s10555-008-9165-4. Review.

PMID:
19169797
[PubMed - indexed for MEDLINE]
6.

Solution- and solid-phase, modular approaches for obtaining different natural product-like polycyclic architectures from an aminoindoline scaffold for combinatorial chemistry.

Reddy PT, Quevillon S, Gan Z, Forbes N, Leek DM, Arya P.

J Comb Chem. 2006 Nov-Dec;8(6):856-71.

PMID:
17096575
[PubMed - indexed for MEDLINE]
7.

Targeting focal adhesion kinase signaling in tumor growth and metastasis.

Schwock J, Dhani N, Hedley DW.

Expert Opin Ther Targets. 2010 Jan;14(1):77-94. doi: 10.1517/14728220903460340. Review.

PMID:
20001212
[PubMed - indexed for MEDLINE]
8.

Integrin alpha2-mediated ERK and calpain activation play a critical role in cell adhesion and motility via focal adhesion kinase signaling: identification of a novel signaling pathway.

Sawhney RS, Cookson MM, Omar Y, Hauser J, Brattain MG.

J Biol Chem. 2006 Mar 31;281(13):8497-510. Epub 2006 Feb 3.

PMID:
16461767
[PubMed - indexed for MEDLINE]
Free Article
9.

An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling.

Pirone DM, Liu WF, Ruiz SA, Gao L, Raghavan S, Lemmon CA, Romer LH, Chen CS.

J Cell Biol. 2006 Jul 17;174(2):277-88.

PMID:
16847103
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

New concepts regarding focal adhesion kinase promotion of cell migration and proliferation.

Cox BD, Natarajan M, Stettner MR, Gladson CL.

J Cell Biochem. 2006 Sep 1;99(1):35-52. Review.

PMID:
16823799
[PubMed - indexed for MEDLINE]
11.

Tumor growth inhibition by synthetic and expressed siRNA targeting focal adhesion kinase.

Tsutsumi K, Kasaoka T, Park HM, Nishiyama H, Nakajima M, Honda T.

Int J Oncol. 2008 Jul;33(1):215-24.

PMID:
18575768
[PubMed - indexed for MEDLINE]
12.

The chemopreventive bioflavonoid apigenin inhibits prostate cancer cell motility through the focal adhesion kinase/Src signaling mechanism.

Franzen CA, Amargo E, Todorović V, Desai BV, Huda S, Mirzoeva S, Chiu K, Grzybowski BA, Chew TL, Green KJ, Pelling JC.

Cancer Prev Res (Phila). 2009 Sep;2(9):830-41. doi: 10.1158/1940-6207.CAPR-09-0066. Epub 2009 Sep 8.

PMID:
19737984
[PubMed - indexed for MEDLINE]
13.

Fragment-based discovery of focal adhesion kinase inhibitors.

Grädler U, Bomke J, Musil D, Dresing V, Lehmann M, Hölzemann G, Greiner H, Esdar C, Krier M, Heinrich T.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5401-9. doi: 10.1016/j.bmcl.2013.07.050. Epub 2013 Jul 31.

PMID:
23973211
[PubMed - indexed for MEDLINE]
14.

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.

Kiely PA, Baillie GS, Barrett R, Buckley DA, Adams DR, Houslay MD, O'Connor R.

J Biol Chem. 2009 Jul 24;284(30):20263-74. doi: 10.1074/jbc.M109.017640. Epub 2009 May 7.

PMID:
19423701
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase.

Park DW, Choi KC, MacCalman CD, Leung PC.

Reprod Biol Endocrinol. 2009 Aug 5;7:81. doi: 10.1186/1477-7827-7-81.

PMID:
19656390
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Migration of renal carcinoma cells is dependent on protein kinase Cdelta via beta1 integrin and focal adhesion kinase.

Brenner W, Greber I, Gudejko-Thiel J, Beitz S, Schneider E, Walenta S, Peters K, Unger R, Thüroff JW.

Int J Oncol. 2008 May;32(5):1125-31.

PMID:
18425341
[PubMed - indexed for MEDLINE]
17.

Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.

Schwock J, Dhani N, Cao MP, Zheng J, Clarkson R, Radulovich N, Navab R, Horn LC, Hedley DW.

Cancer Res. 2009 Jun 1;69(11):4750-9. doi: 10.1158/0008-5472.CAN-09-0454. Epub 2009 May 19.

PMID:
19458065
[PubMed - indexed for MEDLINE]
Free Article
18.

Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo.

Watanabe N, Takaoka M, Sakurama K, Tomono Y, Hatakeyama S, Ohmori O, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Beer DG, Nagatsuka H, Tanaka N, Naomoto Y.

Clin Cancer Res. 2008 Jul 15;14(14):4631-9. doi: 10.1158/1078-0432.CCR-07-4755.

PMID:
18628478
[PubMed - indexed for MEDLINE]
Free Article
19.

Focal adhesion kinase signaling regulates cardiogenesis of embryonic stem cells.

Hakuno D, Takahashi T, Lammerding J, Lee RT.

J Biol Chem. 2005 Nov 25;280(47):39534-44. Epub 2005 Sep 11.

PMID:
16157602
[PubMed - indexed for MEDLINE]
Free Article
20.

Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo.

Liu TJ, LaFortune T, Honda T, Ohmori O, Hatakeyama S, Meyer T, Jackson D, de Groot J, Yung WK.

Mol Cancer Ther. 2007 Apr;6(4):1357-67.

PMID:
17431114
[PubMed - indexed for MEDLINE]
Free Article

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