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Results: 1 to 20 of 147

1.

A complex interplay between Akt, TSC2 and the two mTOR complexes.

Huang J, Manning BD.

Biochem Soc Trans. 2009 Feb;37(Pt 1):217-22. doi: 10.1042/BST0370217. Review.

PMID:
19143635
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.

PMID:
18411301
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors.

Huang J, Wu S, Wu CL, Manning BD.

Cancer Res. 2009 Aug 1;69(15):6107-14. doi: 10.1158/0008-5472.CAN-09-0975. Epub 2009 Jul 14.

PMID:
19602587
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes.

Miyazaki M, McCarthy JJ, Esser KA.

FEBS J. 2010 May;277(9):2180-91. doi: 10.1111/j.1742-4658.2010.07635.x.

PMID:
20412061
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation.

Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K.

Sci Signal. 2012 Mar 27;5(217):ra25. doi: 10.1126/scisignal.2002469.

PMID:
22457331
[PubMed - indexed for MEDLINE]
Free Article
6.

Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.

Zhang HH, Huang J, Düvel K, Boback B, Wu S, Squillace RM, Wu CL, Manning BD.

PLoS One. 2009 Jul 10;4(7):e6189. doi: 10.1371/journal.pone.0006189.

PMID:
19593385
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.

Curr Biol. 2003 Aug 5;13(15):1259-68.

PMID:
12906785
[PubMed - indexed for MEDLINE]
8.

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

Xie J, Ponuwei GA, Moore CE, Willars GB, Tee AR, Herbert TP.

Cell Signal. 2011 Dec;23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. Epub 2011 Jul 6.

PMID:
21763421
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

Nobukini T, Thomas G.

Novartis Found Symp. 2004;262:148-54; discussion 154-9, 265-8. Review.

PMID:
15562827
[PubMed - indexed for MEDLINE]
10.

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.

Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R.

J Cell Biol. 2002 Oct 28;159(2):217-24. Epub 2002 Oct 28.

PMID:
12403809
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition.

Han EK, Leverson JD, McGonigal T, Shah OJ, Woods KW, Hunter T, Giranda VL, Luo Y.

Oncogene. 2007 Aug 16;26(38):5655-61. Epub 2007 Mar 5.

PMID:
17334390
[PubMed - indexed for MEDLINE]
12.

RAD 001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia.

Mancini M, Petta S, Martinelli G, Barbieri E, Santucci MA.

J Cell Biochem. 2010 Feb 1;109(2):320-8. doi: 10.1002/jcb.22380.

PMID:
20014066
[PubMed - indexed for MEDLINE]
13.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

PMID:
19995915
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ.

J Clin Invest. 2003 Oct;112(8):1223-33.

PMID:
14561707
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9. Epub 2005 Jul 15.

PMID:
16027121
[PubMed - indexed for MEDLINE]
Free Article
16.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K, Li Y, Zhu T, Wu J, Guan KL.

Nat Cell Biol. 2002 Sep;4(9):648-57.

PMID:
12172553
[PubMed - indexed for MEDLINE]
17.

Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.

Das F, Ghosh-Choudhury N, Dey N, Mandal CC, Mahimainathan L, Kasinath BS, Abboud HE, Choudhury GG.

J Biol Chem. 2012 Feb 3;287(6):3808-22. doi: 10.1074/jbc.M111.246397. Epub 2011 Dec 19.

PMID:
22184110
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J.

Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13489-94. Epub 2004 Sep 1.

PMID:
15342917
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma.

Lu KH, Wu W, Dave B, Slomovitz BM, Burke TW, Munsell MF, Broaddus RR, Walker CL.

Clin Cancer Res. 2008 May 1;14(9):2543-50. doi: 10.1158/1078-0432.CCR-07-0321.

PMID:
18451215
[PubMed - indexed for MEDLINE]
Free Article
20.

ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling.

Winter JN, Jefferson LS, Kimball SR.

Am J Physiol Cell Physiol. 2011 May;300(5):C1172-80. doi: 10.1152/ajpcell.00504.2010. Epub 2011 Feb 2.

PMID:
21289294
[PubMed - indexed for MEDLINE]
Free PMC Article
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