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Results: 1 to 20 of 113

1.

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes.

Ren YR, Pan F, Parvez S, Fleig A, Chong CR, Xu J, Dang Y, Zhang J, Jiang H, Penner R, Liu JO.

PLoS One. 2008;3(12):e4009. doi: 10.1371/journal.pone.0004009. Epub 2008 Dec 23.

PMID:
19104661
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells.

Leanza L, Henry B, Sassi N, Zoratti M, Chandy KG, Gulbins E, Szabò I.

EMBO Mol Med. 2012 Jul;4(7):577-93. doi: 10.1002/emmm.201200235. Epub 2012 Apr 11.

PMID:
22496117
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.

Varga Z, Gurrola-Briones G, Papp F, Rodríguez de la Vega RC, Pedraza-Alva G, Tajhya RB, Gaspar R, Cardenas L, Rosenstein Y, Beeton C, Possani LD, Panyi G.

Mol Pharmacol. 2012 Sep;82(3):372-82. doi: 10.1124/mol.112.078006. Epub 2012 May 23.

PMID:
22622363
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Immunomodulatory effects of diclofenac in leukocytes through the targeting of Kv1.3 voltage-dependent potassium channels.

Villalonga N, David M, Bielańska J, González T, Parra D, Soler C, Comes N, Valenzuela C, Felipe A.

Biochem Pharmacol. 2010 Sep 15;80(6):858-66. doi: 10.1016/j.bcp.2010.05.012. Epub 2010 May 19.

PMID:
20488163
[PubMed - indexed for MEDLINE]
5.

18β-Glycyrrhetinic acid potently inhibits Kv1.3 potassium channels and T cell activation in human Jurkat T cells.

Fu XX, Du LL, Zhao N, Dong Q, Liao YH, Du YM.

J Ethnopharmacol. 2013 Jul 9;148(2):647-54. doi: 10.1016/j.jep.2013.05.022. Epub 2013 May 21.

PMID:
23707333
[PubMed - indexed for MEDLINE]
6.

Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation.

Beeton C, Barbaria J, Giraud P, Devaux J, Benoliel AM, Gola M, Sabatier JM, Bernard D, Crest M, Béraud E.

J Immunol. 2001 Jan 15;166(2):936-44.

PMID:
11145670
[PubMed - indexed for MEDLINE]
Free Article
7.

Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model.

Li Z, Liu WH, Han S, Peng BW, Yin J, Wu YL, He XH, Li WX.

J Biol Chem. 2012 Aug 24;287(35):29479-94. doi: 10.1074/jbc.M112.379594. Epub 2012 Jul 3.

PMID:
22761436
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Blockade of Kv1.3 potassium channels inhibits differentiation and granzyme B secretion of human CD8+ T effector memory lymphocytes.

Hu L, Wang T, Gocke AR, Nath A, Zhang H, Margolick JB, Whartenby KA, Calabresi PA.

PLoS One. 2013;8(1):e54267. doi: 10.1371/journal.pone.0054267. Epub 2013 Jan 30.

PMID:
23382885
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.

Hu L, Pennington M, Jiang Q, Whartenby KA, Calabresi PA.

J Immunol. 2007 Oct 1;179(7):4563-70.

PMID:
17878353
[PubMed - indexed for MEDLINE]
Free Article
10.

Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease.

Han S, Yi H, Yin SJ, Chen ZY, Liu H, Cao ZJ, Wu YL, Li WX.

J Biol Chem. 2008 Jul 4;283(27):19058-65. doi: 10.1074/jbc.M802054200. Epub 2008 May 14.

PMID:
18480054
[PubMed - indexed for MEDLINE]
Free Article
11.

Granzyme B-induced neurotoxicity is mediated via activation of PAR-1 receptor and Kv1.3 channel.

Wang T, Lee MH, Choi E, Pardo-Villamizar CA, Lee SB, Yang IH, Calabresi PA, Nath A.

PLoS One. 2012;7(8):e43950. doi: 10.1371/journal.pone.0043950. Epub 2012 Aug 29.

PMID:
22952817
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG.

Mol Pharmacol. 2005 Apr;67(4):1369-81. Epub 2005 Jan 21.

PMID:
15665253
[PubMed - indexed for MEDLINE]
Free Article
13.

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis.

Rangaraju S, Chi V, Pennington MW, Chandy KG.

Expert Opin Ther Targets. 2009 Aug;13(8):909-24. doi: 10.1517/14728220903018957. Review.

PMID:
19538097
[PubMed - indexed for MEDLINE]
14.

Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.

Kahlfuß S, Simma N, Mankiewicz J, Bose T, Lowinus T, Klein-Hessling S, Sprengel R, Schraven B, Heine M, Bommhardt U.

Mol Cell Biol. 2014 Mar;34(5):820-31. doi: 10.1128/MCB.01273-13. Epub 2013 Dec 16.

PMID:
24344200
[PubMed - indexed for MEDLINE]
15.

Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells.

Zhao N, Dong Q, Du LL, Fu XX, Du YM, Liao YH.

PLoS One. 2013 May 22;8(5):e64629. doi: 10.1371/journal.pone.0064629. Print 2013.

PMID:
23717641
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS.

Wulff H, Calabresi PA, Allie R, Yun S, Pennington M, Beeton C, Chandy KG.

J Clin Invest. 2003 Jun;111(11):1703-13. Erratum in: J Clin Invest. 2003 Jul;112(2):298.

PMID:
12782673
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The beneficial effect of blocking Kv1.3 in the psoriasiform SCID mouse model.

Gilhar A, Bergman R, Assay B, Ullmann Y, Etzioni A.

J Invest Dermatol. 2011 Jan;131(1):118-24. doi: 10.1038/jid.2010.245. Epub 2010 Aug 26.

PMID:
20739949
[PubMed - indexed for MEDLINE]
Free Article
18.

Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease.

Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, Knapp B, Kentala D, Hansen Z, Pennington MW, Beeton C, Chandy KG, Iadonato SP.

J Pharmacol Exp Ther. 2012 Sep;342(3):642-53. doi: 10.1124/jpet.112.191890. Epub 2012 May 25.

PMID:
22637724
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

T-lymphocyte calcium influx characteristics and their modulation by Kv1.3 and IKCa1 channel inhibitors in the neonate.

Toldi G, Treszl A, Pongor V, Gyarmati B, Tulassay T, Vásárhelyi B.

Int Immunol. 2010 Sep;22(9):769-74. doi: 10.1093/intimm/dxq063. Epub 2010 Jul 2.

PMID:
20601376
[PubMed - indexed for MEDLINE]
Free Article
20.

Targeting effector memory T-cells with Kv1.3 blockers.

Wulff H, Pennington M.

Curr Opin Drug Discov Devel. 2007 Jul;10(4):438-45. Review.

PMID:
17659485
[PubMed - indexed for MEDLINE]

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