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Results: 1 to 20 of 100

1.

Highly parallel identification of essential genes in cancer cells.

Luo B, Cheung HW, Subramanian A, Sharifnia T, Okamoto M, Yang X, Hinkle G, Boehm JS, Beroukhim R, Weir BA, Mermel C, Barbie DA, Awad T, Zhou X, Nguyen T, Piqani B, Li C, Golub TR, Meyerson M, Hacohen N, Hahn WC, Lander ES, Sabatini DM, Root DE.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20380-5. doi: 10.1073/pnas.0810485105. Epub 2008 Dec 17.

PMID:
19091943
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Functional genomics to explore cancer cell vulnerabilities.

Kahle KT, Kozono D, Ng K, Hsieh G, Zinn PO, Nitta M, Chen CC.

Neurosurg Focus. 2010 Jan;28(1):E5. doi: 10.3171/2009.10.FOCUS09212.

PMID:
20043720
[PubMed - indexed for MEDLINE]
3.

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, Vizeacoumar FS, Datti A, Kasimer D, Buzina A, Mero P, Misquitta C, Normand J, Haider M, Ketela T, Wrana JL, Rottapel R, Neel BG, Moffat J.

Cancer Discov. 2012 Feb;2(2):172-89. doi: 10.1158/2159-8290.CD-11-0224. Epub 2011 Dec 29.

PMID:
22585861
[PubMed - indexed for MEDLINE]
4.

Cancer proliferation gene discovery through functional genomics.

Schlabach MR, Luo J, Solimini NL, Hu G, Xu Q, Li MZ, Zhao Z, Smogorzewska A, Sowa ME, Ang XL, Westbrook TF, Liang AC, Chang K, Hackett JA, Harper JW, Hannon GJ, Elledge SJ.

Science. 2008 Feb 1;319(5863):620-4. doi: 10.1126/science.1149200. Erratum in: Science.2008 Apr 18;320(5874):316.

PMID:
18239126
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Integrative genomic approaches to understanding cancer.

Hahn WC, Dunn IF, Kim SY, Schinzel AC, Firestein R, Guney I, Boehm JS.

Biochim Biophys Acta. 2009 Jun;1790(6):478-84. doi: 10.1016/j.bbagen.2009.02.003. Epub 2009 Feb 11. Review.

PMID:
19364473
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer.

Cheung HW, Cowley GS, Weir BA, Boehm JS, Rusin S, Scott JA, East A, Ali LD, Lizotte PH, Wong TC, Jiang G, Hsiao J, Mermel CH, Getz G, Barretina J, Gopal S, Tamayo P, Gould J, Tsherniak A, Stransky N, Luo B, Ren Y, Drapkin R, Bhatia SN, Mesirov JP, Garraway LA, Meyerson M, Lander ES, Root DE, Hahn WC.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12372-7. doi: 10.1073/pnas.1109363108. Epub 2011 Jul 11.

PMID:
21746896
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Cancer Drug Development: New Targets for Cancer Treatment.

Curt GA.

Oncologist. 1996;1(3):II-III.

PMID:
10387987
[PubMed - as supplied by publisher]
8.

Functional genomics and cancer drug target discovery.

Moody SE, Boehm JS, Barbie DA, Hahn WC.

Curr Opin Mol Ther. 2010 Jun;12(3):284-93. Review.

PMID:
20521217
[PubMed - indexed for MEDLINE]
9.

Differentiation primary response genes and proto-oncogenes as positive and negative regulators of terminal hematopoietic cell differentiation.

Liebermann DA, Hoffman B.

Stem Cells. 1994 Jul;12(4):352-69. Review.

PMID:
7951003
[PubMed - indexed for MEDLINE]
10.

Identification of putative oncogenes in lung adenocarcinoma by a comprehensive functional genomic approach.

Li R, Wang H, Bekele BN, Yin Z, Caraway NP, Katz RL, Stass SA, Jiang F.

Oncogene. 2006 Apr 27;25(18):2628-35.

PMID:
16369491
[PubMed - indexed for MEDLINE]
11.

Pooled lentiviral shRNA screening for functional genomics in mammalian cells.

Blakely K, Ketela T, Moffat J.

Methods Mol Biol. 2011;781:161-82. doi: 10.1007/978-1-61779-276-2_9.

PMID:
21877282
[PubMed - indexed for MEDLINE]
12.

Designing, optimizing, and implementing high-throughput siRNA genomic screening with glioma cells for the discovery of survival genes and novel drug targets.

Thaker NG, McDonald PR, Zhang F, Kitchens CA, Shun TY, Pollack IF, Lazo JS.

J Neurosci Methods. 2010 Jan 15;185(2):204-12. doi: 10.1016/j.jneumeth.2009.09.023. Epub 2009 Sep 25.

PMID:
19782703
[PubMed - indexed for MEDLINE]
13.

Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer.

Wrzeszczynski KO, Varadan V, Byrnes J, Lum E, Kamalakaran S, Levine DA, Dimitrova N, Zhang MQ, Lucito R.

PLoS One. 2011;6(12):e28503. doi: 10.1371/journal.pone.0028503. Epub 2011 Dec 8.

PMID:
22174824
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Miniature short hairpin RNA screens to characterize antiproliferative drugs.

Kittanakom S, Arnoldo A, Brown KR, Wallace I, Kunavisarut T, Torti D, Heisler LE, Surendra A, Moffat J, Giaever G, Nislow C.

G3 (Bethesda). 2013 Aug 7;3(8):1375-87. doi: 10.1534/g3.113.006437.

PMID:
23797109
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Role of genomics in identifying new targets for cancer therapy.

Anzick SL, Trent JM.

Oncology (Williston Park). 2002 May;16(5 Suppl 4):7-13. Review.

PMID:
12102580
[PubMed - indexed for MEDLINE]
Free Article
16.

COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines.

Koh JL, Brown KR, Sayad A, Kasimer D, Ketela T, Moffat J.

Nucleic Acids Res. 2012 Jan;40(Database issue):D957-63. doi: 10.1093/nar/gkr959. Epub 2011 Nov 18.

PMID:
22102578
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, Morais P, Meltzer J, Korejwa A, Jané-Valbuena J, Mapa FA, Thibault J, Bric-Furlong E, Raman P, Shipway A, Engels IH, Cheng J, Yu GK, Yu J, Aspesi P Jr, de Silva M, Jagtap K, Jones MD, Wang L, Hatton C, Palescandolo E, Gupta S, Mahan S, Sougnez C, Onofrio RC, Liefeld T, MacConaill L, Winckler W, Reich M, Li N, Mesirov JP, Gabriel SB, Getz G, Ardlie K, Chan V, Myer VE, Weber BL, Porter J, Warmuth M, Finan P, Harris JL, Meyerson M, Golub TR, Morrissey MP, Sellers WR, Schlegel R, Garraway LA.

Nature. 2012 Mar 28;483(7391):603-7. doi: 10.1038/nature11003. Erratum in: Nature. 2012 Dec 13;492(7428):290.

PMID:
22460905
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The opportunities and challenges of personalized genome-based molecular therapies for cancer: targets, technologies, and molecular chaperones.

Workman P.

Cancer Chemother Pharmacol. 2003 Jul;52 Suppl 1:S45-56. Epub 2003 Jun 18. Review.

PMID:
12819933
[PubMed - indexed for MEDLINE]
19.

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.

Flanagan JM, Funes JM, Henderson S, Wild L, Carey N, Boshoff C.

Mol Cancer Ther. 2009 Jan;8(1):249-60. doi: 10.1158/1535-7163.MCT-08-0636.

PMID:
19139135
[PubMed - indexed for MEDLINE]
Free Article
20.

Report of a meeting: molecular basis of cancer therapy.

Gottesman MM.

J Natl Cancer Inst. 1994 Sep 7;86(17):1277-85.

PMID:
7914937
[PubMed - indexed for MEDLINE]

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