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19087175,9619378,14617687,15993445,14759590,10857755,15283957,20470889,9262354,16751254,14966301,15936785,16039791,20926198,9806338,15024756,20045008,16842830,18511291,17074047,18471873,11821653,18664365,16530273,15919060,20361987,19958757,16721697,15388782,16039792,20182518,17445782,15064134,16393156,21192080,15706927,18191534,19258490,21303668,8563722,15899940,18953098,15020061,10077334,15000880,15223234,18255258,16934544,1602402,16360283,8046632,17331478,17224133,15178153,16886979,9831177,21466824,12015387,16950633,11973588,19299019,15581737,11179401,15297033,15110927,17703884,16959954,15967631,19235895,18073507,15501601,11113345,12871965,18590773,15327921,16325304,18207648,17656565,23548702,18601929,18634831,17339098,15900319,19115392,11122354,18164129,11189019,9326296,10381603,15680958,15466457,9827358,19428561,15882780,12811812,15589036,19171179,15481803,21722710,18252949,15554915,9105702,16165281,16451221,18455872,12616337,21521653,16242909,10601817,15996692,17366612,19074588,9570721,15050649,15353218,15763167,31310797,18973603,19046297,16157456,17201586,11751035,1776527,16762379,18639741,18299269,19428634,24440143,21183317,9439800,19420012,17920645,16904952,16814258,10678764,19786543,19523782,17174721,19321149,19318418,18573547,12010759,8770025,12186691,11521445,18973546,15364018,19346005,19604644,24651990,16820025,15967447,8677009,15589041,19474210,18598258,17363226,19341730,18457866,18282557,17433545,11951059,8092314,24621600,19326443,18255192,11742223,10378870,18455806,9575956,20345592,17968946,7536823,17345100,17544458,18499089,19275930,26385227,18973601,10101735,11951119,8772479,12353224,11306198,17700577,17826174,27016016,18646209,25108212,22880741,8726665,11765048,8243337,19557603,7476020,11891437,10408981,17686536,19409213,15934938,19614750,16644794,17967442,17047394,19152833,10070123,26531693,16375968,22981168,19735705,28931410,19004647,18596024,10921998,17604006,11292006,17005162,19617658,19458323,16556139,9629245,19540866,23500835,19558463,19344884,19428555,19359223,9828220,8462448,9466417,18597948,17713352,12692173,15919760,15544852,16844207,17617389,22925041,16844151,17640050,16934876,23791686,23331909,19453497,17482371,18282478,15464048,21055422,6800001,11189020,19236331,16217019,7606464,19722155,11931854,18929155,22328591,19251936,20686201,17382514,18786731,19258032,2955042,16455768,16274848,17824899,16094315,15808891,10098870,23634700,19414023,9177560,17138728,27261351,19046143,19008121,1913242,11993182,16616943,21643979,8622824,18996162,17097645,17618697,17097765,1461574,18037266,1415654,26937856,18821705,21595923,15652387,19041259,23872358,10896869,24161357,22902349,11189018,18062978,9565638,20303405,17920716,22304959,18279308,19937527,22884959,17964733,15059678,15527749,17683829,9094441,15953659,10922015,18491079,10208918,17097068,17967544,16226008,17678879,16490223,16623844,9409716,18495183,1662389,18088277,20079357,12910627,8783197,15652652,16391709,25439028,34465372,10806313,16146653,15930379,9729338,18300022,10822165,19076365,17898318,26984577,14578583,8868260,9128919,16753141,28057525,27764704,10350527,21745542,18045669,17035503,8024037,12175593,8413826,18753064,15205185,21162122,34681254,18624935,9252034,7631887,1369606,18508098,18852021,9482808,8294551,15509232,14596894,12864980,9663558,11755125,18617619,11006436,19254758,25697068,18634385,26775112,15814729,26117716,9523902,18725269,24114176,18694739,15501140,11595215,26616874,29121947,28330778,22465167,28823689,18382067,9150189,17011587,1387028,8551238,28655587,16677721,17054999,26928198,11289386,18166492,18198674,10196453,22267332,18838174,12620648,9523005,26290874,12481156,9175096,12044467,11259077,18841529,29031549,17156928,11189034,17452054,16554088,18672009,23391884,26830488,8874144,10666132,18950689,10878499,22982341,10686346,22610882,2104223,9766398,11833417,12074913,17974132,17960764,7796118,29574261,18601710,24704101,17397936,9227603,19701769,16364817,8446696,11420064,10852228,16902799,16583240,17263512,19061907,8510801,23146654,17196563,9841556,17593929,17242474,30423398,16238458,14506630,11814650,33747797,18668691,15949134,18514328,9585109,18284608,8945946,27504457,33033375,17543422,8916081,18284816,2548213,17884191,3401558,16580030,11285013,22164271,7987701,32513828,15983784,10079011,27184538,23388469,9141147,9791084,8997368,18045696,35817135,22871632,8221116,7609880,9733932,10794511,7969779,23266424,12907843,7503324,11124581,18448612,10860021,28090781,10393516,9629246,16401543,9622633,24838082,9218251,22023756,18068739,26829940,17977038,29026538,18082228,12401469,21675202,36720350,12458036,31079141,12687152,29759136,12001729,9298510,15727205,33673103,22639228,18175834,17645932,17898219,16307587,24021926,21161038,8846074,17367989,17290560,21111041,30196086,19774496,9629285,34589786,9060579,16170230,10794493,1476182,24126927,19049673,8745567,28939427,24338284,7677401,9219943,18534560,1393581,18000066,16877116,17073657,8295729,15070082,30508550,9875707,22172640,7825822,12000023,21106598,21572657,29678795,15481373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Central nervous action of interleukin-1 mediates activation of limbic structures and behavioural depression in response to peripheral administration of bacterial lipopolysaccharide.

Konsman JP, Veeneman J, Combe C, Poole S, Luheshi GN, Dantzer R. Konsman JP, et al. Eur J Neurosci. 2008 Dec;28(12):2499-510. doi: 10.1111/j.1460-9568.2008.06549.x. Eur J Neurosci. 2008. PMID: 19087175

Different roles of brain interleukin 1 in the adrenocorticotropin response to central versus peripheral administration of lipopolysaccharide in the rat.

Habu S, Watanobe H, Yasujima M, Suda T. Habu S, et al. Cytokine. 1998 May;10(5):390-4. doi: 10.1006/cyto.1997.0296. Cytokine. 1998. PMID: 9619378

The effect of central injection of angiotensin-converting enzyme inhibitor and the angiotensin type 1 receptor antagonist on the induction by lipopolysaccharide of fever and brain interleukin-1beta response in rats.

Shimizu H, Miyoshi M, Matsumoto K, Goto O, Imoto T, Watanabe T. Shimizu H, et al. J Pharmacol Exp Ther. 2004 Mar;308(3):865-73. doi: 10.1124/jpet.103.060392. Epub 2003 Nov 14. J Pharmacol Exp Ther. 2004. PMID: 14617687

Dissection of peripheral and central endogenous opioid modulation of systemic interleukin-1beta responses using c-fos expression in the rat brain.

Buller KM, Hamlin AS, Osborne PB. Buller KM, et al. Neuropharmacology. 2005 Aug;49(2):230-42. doi: 10.1016/j.neuropharm.2005.03.014. Neuropharmacology. 2005. PMID: 15993445

Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei.

Marvel FA, Chen CC, Badr N, Gaykema RP, Goehler LE. Marvel FA, et al. Brain Behav Immun. 2004 Mar;18(2):123-34. doi: 10.1016/j.bbi.2003.09.004. Brain Behav Immun. 2004. PMID: 14759590

Expression of interleukin 1 alpha and beta, and interleukin 1 receptor antagonist mRNA in the rat central nervous system after peripheral administration of lipopolysaccharides.

Eriksson C, Nobel S, Winblad B, Schultzberg M. Eriksson C, et al. Cytokine. 2000 May;12(5):423-31. doi: 10.1006/cyto.1999.0582. Cytokine. 2000. PMID: 10857755

The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses.

Johnson JD, O'Connor KA, Watkins LR, Maier SF. Johnson JD, et al. Neuroscience. 2004;127(3):569-77. doi: 10.1016/j.neuroscience.2004.05.046. Neuroscience. 2004. PMID: 15283957

Brain cyclooxygenase-2 mediates interleukin-1-induced cellular activation in preoptic and arcuate hypothalamus, but not sickness symptoms.

Nadjar A, Sauvant J, Combe C, Parnet P, Konsman JP. Nadjar A, et al. Neurobiol Dis. 2010 Sep;39(3):393-401. doi: 10.1016/j.nbd.2010.05.005. Epub 2010 May 11. Neurobiol Dis. 2010. PMID: 20470889

The effect of central angiotensin II receptor blockade on interleukin-1beta- and prostaglandin E-induced fevers in rats: possible involvement of brain angiotensin II receptor in fever induction.

Watanabe T, Saiki Y, Sakata Y. Watanabe T, et al. J Pharmacol Exp Ther. 1997 Aug;282(2):873-81. J Pharmacol Exp Ther. 1997. PMID: 9262354

Effect of natriuretic peptide receptor antagonist on lipopolysaccharide-induced fever in rats: is natriuretic peptide an endogenous antipyretic?

Miyoshi M, Kitagawa Y, Imoto T, Watanabe T. Miyoshi M, et al. J Pharmacol Exp Ther. 2006 Sep;318(3):1163-70. doi: 10.1124/jpet.106.102731. Epub 2006 Jun 2. J Pharmacol Exp Ther. 2006. PMID: 16751254

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