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A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury.

Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell'accio F.

Osteoarthritis Cartilage. 2009 Jun;17(6):695-704. doi: 10.1016/j.joca.2008.11.003. Epub 2008 Nov 13.


Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).

Nishida T, Kubota S, Kojima S, Kuboki T, Nakao K, Kushibiki T, Tabata Y, Takigawa M.

J Bone Miner Res. 2004 Aug;19(8):1308-19. Epub 2004 Mar 29.


VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.

Singer II, Kawka DW, Bayne EK, Donatelli SA, Weidner JR, Williams HR, Ayala JM, Mumford RA, Lark MW, Glant TT, et al.

J Clin Invest. 1995 May;95(5):2178-86.


Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS.

J Clin Invest. 1997 Jul 1;100(1):93-106.


Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.

van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, van den Berg WB.

Arthritis Rheum. 1999 Jun;42(6):1128-39.


Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration.

Janusz MJ, Little CB, King LE, Hookfin EB, Brown KK, Heitmeyer SA, Caterson B, Poole AR, Taiwo YO.

Osteoarthritis Cartilage. 2004 Sep;12(9):720-8.


Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis.

van Lent PL, Hofkens W, Blom AB, Grevers L, Sloetjes A, Takahashi N, van Tits LJ, Vogl T, Roth J, de Winther MP, van den Berg WB.

Arthritis Rheum. 2009 Oct;60(10):2954-65. doi: 10.1002/art.24908.


Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3.

Blom AB, van Lent PL, Libregts S, Holthuysen AE, van der Kraan PM, van Rooijen N, van den Berg WB.

Arthritis Rheum. 2007 Jan;56(1):147-57.


Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice.

Sahebjam S, Khokha R, Mort JS.

Arthritis Rheum. 2007 Mar;56(3):905-9.


Expression of type X collagen in young and old C57Bl/6 and Balb/c mice. Relation with articular cartilage degeneration.

van der Kraan PM, Stoop R, Meijers TH, Poole AR, van den Berg WB.

Osteoarthritis Cartilage. 2001 Feb;9(2):92-100.


Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees.

Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS.

Arthritis Rheum. 2010 May;62(5):1393-402. doi: 10.1002/art.27357.


Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice.

Lapveteläinen T, Hyttinen MM, Säämänen AM, Långsjö T, Sahlman J, Felszeghy S, Vuorio E, Helminen HJ.

Ann Rheum Dis. 2002 Sep;61(9):810-7.


Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.

Lohmander LS, Ionescu M, Jugessur H, Poole AR.

Arthritis Rheum. 1999 Mar;42(3):534-44.


MMP proteolysis of the human extracellular matrix protein aggrecan is mainly a process of normal turnover.

Struglics A, Hansson M.

Biochem J. 2012 Sep 1;446(2):213-23. doi: 10.1042/BJ20120274.


Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.

Singer II, Scott S, Kawka DW, Bayne EK, Weidner JR, Williams HR, Mumford RA, Lark MW, McDonnell J, Christen AJ, Moore VL, Mudgett JS, Visco DM.

Osteoarthritis Cartilage. 1997 Nov;5(6):407-18.

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