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Results: 1 to 20 of 99

1.

Microtubule binding and disruption and induction of premature senescence by disorazole C(1).

Tierno MB, Kitchens CA, Petrik B, Graham TH, Wipf P, Xu FL, Saunders WS, Raccor BS, Balachandran R, Day BW, Stout JR, Walczak CE, Ducruet AP, Reese CE, Lazo JS.

J Pharmacol Exp Ther. 2009 Mar;328(3):715-22. doi: 10.1124/jpet.108.147330. Epub 2008 Dec 9.

PMID:
19066338
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1.

Lazo JS, Reese CE, Vogt A, Vollmer LL, Kitchens CA, Günther E, Graham TH, Hopkins CD, Wipf P.

J Pharmacol Exp Ther. 2010 Mar;332(3):906-11. doi: 10.1124/jpet.109.162842. Epub 2009 Dec 15.

PMID:
20008956
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides.

Hopkins CD, Wipf P.

Nat Prod Rep. 2009 May;26(5):585-601. doi: 10.1039/b813799b. Epub 2009 Mar 11. Review.

PMID:
19387496
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product.

Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS.

Chem Biol Drug Des. 2006 Jan;67(1):66-73.

PMID:
16492150
[PubMed - indexed for MEDLINE]
5.

Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Bai R, Cichacz ZA, Herald CL, Pettit GR, Hamel E.

Mol Pharmacol. 1993 Oct;44(4):757-66.

PMID:
8232226
[PubMed - indexed for MEDLINE]
6.

Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells.

Elnakady YA, Sasse F, Lünsdorf H, Reichenbach H.

Biochem Pharmacol. 2004 Mar 1;67(5):927-35.

PMID:
15104246
[PubMed - indexed for MEDLINE]
7.

Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.

Cruz-Monserrate Z, Vervoort HC, Bai R, Newman DJ, Howell SB, Los G, Mullaney JT, Williams MD, Pettit GR, Fenical W, Hamel E.

Mol Pharmacol. 2003 Jun;63(6):1273-80.

PMID:
12761336
[PubMed - indexed for MEDLINE]
Free Article
8.

Genistein arrests cell cycle progression of A549 cells at the G(2)/M phase and depolymerizes interphase microtubules through binding to a unique site of tubulin.

Mukherjee S, Acharya BR, Bhattacharyya B, Chakrabarti G.

Biochemistry. 2010 Mar 2;49(8):1702-12. doi: 10.1021/bi901760d.

PMID:
20085293
[PubMed - indexed for MEDLINE]
9.

Theaflavins depolymerize microtubule network through tubulin binding and cause apoptosis of cervical carcinoma HeLa cells.

Chakrabarty S, Das A, Bhattacharya A, Chakrabarti G.

J Agric Food Chem. 2011 Mar 9;59(5):2040-8. doi: 10.1021/jf104231b. Epub 2011 Feb 16.

PMID:
21323312
[PubMed - indexed for MEDLINE]
10.

The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E.

Biochemistry. 1995 Aug 1;34(30):9714-21.

PMID:
7626642
[PubMed - indexed for MEDLINE]
11.

Inhibition of mitosis and microtubule function through direct tubulin binding by a novel antiproliferative naphthopyran LY290181.

Wood DL, Panda D, Wiernicki TR, Wilson L, Jordan MA, Singh JP.

Mol Pharmacol. 1997 Sep;52(3):437-44.

PMID:
9281606
[PubMed - indexed for MEDLINE]
Free Article
12.

Antimitotic antifungal compound benomyl inhibits brain microtubule polymerization and dynamics and cancer cell proliferation at mitosis, by binding to a novel site in tubulin.

Gupta K, Bishop J, Peck A, Brown J, Wilson L, Panda D.

Biochemistry. 2004 Jun 1;43(21):6645-55.

PMID:
15157098
[PubMed - indexed for MEDLINE]
13.

A-204197, a new tubulin-binding agent with antimitotic activity in tumor cell lines resistant to known microtubule inhibitors.

Tahir SK, Han EK, Credo B, Jae HS, Pietenpol JA, Scatena CD, Wu-Wong JR, Frost D, Sham H, Rosenberg SH, Ng SC.

Cancer Res. 2001 Jul 15;61(14):5480-5.

PMID:
11454695
[PubMed - indexed for MEDLINE]
Free Article
14.

The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation.

Carvalho R, Reid R, Viswanathan N, Gramajo H, Julien B.

Gene. 2005 Oct 10;359:91-8.

PMID:
16084035
[PubMed - indexed for MEDLINE]
15.

Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin.

Kuznetsov G, TenDyke K, Towle MJ, Cheng H, Liu J, Marsh JP, Schiller SE, Spyvee MR, Yang H, Seletsky BM, Shaffer CJ, Marceau V, Yao Y, Suh EM, Campagna S, Fang FG, Kowalczyk JJ, Littlefield BA.

Mol Cancer Ther. 2009 Oct;8(10):2852-60. doi: 10.1158/1535-7163.MCT-09-0301.

PMID:
19825803
[PubMed - indexed for MEDLINE]
Free Article
16.

Characterization of the interaction of TZT-1027, a potent antitumor agent, with tubulin.

Natsume T, Watanabe J, Tamaoki S, Fujio N, Miyasaka K, Kobayashi M.

Jpn J Cancer Res. 2000 Jul;91(7):737-47.

PMID:
10920282
[PubMed - indexed for MEDLINE]
17.

LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.

de Arruda M, Cocchiaro CA, Nelson CM, Grinnell CM, Janssen B, Haupt A, Barlozzari T.

Cancer Res. 1995 Jul 15;55(14):3085-92.

PMID:
7606731
[PubMed - indexed for MEDLINE]
Free Article
18.

Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1.

Xu FL, Rbaibi Y, Kiselyov K, Lazo JS, Wipf P, Saunders WS.

BMC Chem Biol. 2010 Feb 11;10:1. doi: 10.1186/1472-6769-10-1.

PMID:
20181182
[PubMed]
Free PMC Article
19.

Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines.

Ling YH, Jiang JD, Holland JF, Perez-Soler R.

Mol Pharmacol. 2002 Sep;62(3):529-38.

PMID:
12181429
[PubMed - indexed for MEDLINE]
Free Article
20.

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

Bai R, Friedman SJ, Pettit GR, Hamel E.

Biochem Pharmacol. 1992 Jun 23;43(12):2637-45.

PMID:
1632820
[PubMed - indexed for MEDLINE]

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