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19061776,19781442,18206533,15085930,23388461,20620590,16271955,11013390,10697602,15162061,15236315,15677628,12461745,2835156,17387035,3335032,9281365,26500699,11836581,16688757,15760839,15574761,19188701,11751406,16551697,17431320,12810674,16052508,10537310,15613287,1503405,16373963,10867141,15066322,19020304,16600619,30096943,18630328,14533001,21666415,12939745,24134916,21925300,12661010,9811862,16123119,16204030,15188456,25614763,16941002,19414372,3264269,7652935,826168,6883337,1803707,26555863,12192596,9027012,28633018,22732493,30463904,18294777,16328063,15743675,15530539,15309517,16116624,8917370,7890274,19389507,9270012,17088976,15105448,7762996,15188452,17517657,16627957,30204765,17072887,7281231,15549096,23416057,11997480,2720688,17657945,2720687,18487697,17191108,20676137,6939649,16222248,18283116,15750026,17610862,27246460,20964798,17126026,11319171,3458336,23074853,4089964,19291800,11830638,28089890,12742157,17084022,6375054,18456432,16854538,19567078,16023792,10923254,11103821,17257397,17720778,15808870,34266888,18162433,15041217,14500702,7471065,18979540,1447821,19344645,15865924,9568049,23709119,26212324,36654508,19481101,18253026,27930335,19167608,19493885,15548691,10725343,17222786,35380536,19414482,21254554,16921376,22615582,17317954,16955468,16490594,19219654,15968094,12722476,3206547,7468645,6636835,14695175,17044051,16034824,12127394,26837754,8200102,18369759,16157205,36859339,17889705,21311181,16868879,6257592,18930838,192902,19781438,26066710,18771171,21124017,18192061,16450341,23894657,17483087,11601399,20721738,30909073,28018487,15041228,15548689,19396865,29804667,24324169,22377695,26376878,19242928,17360454,18504363,10687734,16995901,17342920,23318433,34352223,15645488,16202681,15481531,27345585,22926916,17341473,18083744,24041940,28741487,25639739,1919173,15542256,18007651,11905807,18425473,15340427,31036964,8723631,15305061,11550911,16716366,15665310,10359645,29371887,22384695,19372582,16169667,18318219,17061062,16978449,19733349,19074902,15138997,24236325,18440524,14633664,6543705,7681544,7768436,19195877,16697121,30420473,18615677,25509141,29847804,1323537,7680222,27496052,3026610,14989177,17849499,34266887,7715203,7281230,18821574,21714908,12744215,18720523,19379326,19110644,15315804,19347270,29800151,17250959,16777991,15613288,31109140,6288326,19764650,18629658,25739518,28213433,19603060,20876566,20715000,20123995,18599223,22161874,19699459,27343755,29708530,8472613,29189717,19198541,18350279,22723011,16187738,19546858,19153074,19446745,19096211,7829223,29275292,18953431,18764919,19556783,31548659,22269907,25019198,19594544,27001151,23760367,19222471,22614003,19096208,9405643,17722107,11761268,23619298,11922387,1660787,15729410,18093868,3476189,10519071,32873156,30509947,24295790,19729918,36689467,8688847,23446188,23152605,19065540,15326384,10462416,6112861,2995175,28192779,14696260,3466673,29160563,26322910,23991060,18822864,33596973,24413397,20041355,17523850,19754273,27004936,33305692,7104989,20962780,17189716,17612874,34341000,12734426,18614394,17406308,6499742,15703300,30220330,18974340,4293562,26204159,7199026,18067085,32887685,29496963,2583864,23555645,5148770,18000376,21852505,17627882,33003307,35701073,15805239,16711392,26859353,15190212,10591121,22145366,15315803,17406243,7736605,23124507,22801546,9707619,33847264,28049655,17500414,1056683,4821220,29478186,25934502,2696969,6266943,15668327,2823107,15613282,18023124,15162068,27893964,3594417,18783893,16906485,12403177,34593353,6651019,28977555,20141513,10601543,16298041,29452566,17330036,24641887,3510860,3422226,18564502,16102591,22426433,6786419,11033866,1971914,5768876,18050084,21535262,17582998,18256770,2202218,12951588,25784636,12461184,6290374,4030141,15466185,14989178,31174021,27013377,1272267,16043196,18154128,18758161,21505791,4915329,26841871,21107781,3180844,18499509,18825959,29625384,7621404,22426881,36761105,21925299,4304841,8956863,9487513,15125643,6861522,3466669,17990957,25708466,22565320,25771981,24316131,21872963,17292823,18419597,29141589,6861146,16814328,36002148,30144379,23595307,7678896,16405914,19424483,32753390,16604101,20655187,18769133,10563392,24569866,11558371,16969800,24118136,26026906,12414667,18620232,35783258,18791275,26945893,170191,5407693,25132386,22948965,1316810,31730858,25043504,22057114,35563836,12711216,26791998,24464829,7828152,25565635,17969847,24899134,18509849,15735007,1423237,21980425,7331995,33957932,23108329,12432267,14564053,203114,24005638,34343239,22863619,6700615,2065293,19305140,4660940,22120710,18021350,11895479,26919076,19061834,24548329,2350353,10526528,17836517,18598571,31242809,35869285,16952055,36291770,28800914,30794535,22804579,7923072,23403271,21380705,24122714,2070823,22968442,20594351,22072070,26321163,13972080,23422884,34211178,25270265,33707361,10585253,17086421,7518044,28388408,32123538,19136519,24183448,8780754,4993379,18623552,17582995,15197343,7809961,2317771,17850598,32200034,19267599,12165455,2070827,16039068,21204268,4282618,4010683,24488973,2209016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667 results

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Cancer-causing karyotypes: chromosomal equilibria between destabilizing aneuploidy and stabilizing selection for oncogenic function.

Li L, McCormack AA, Nicholson JM, Fabarius A, Hehlmann R, Sachs RK, Duesberg PH. Li L, et al. Cancer Genet Cytogenet. 2009 Jan 1;188(1):1-25. doi: 10.1016/j.cancergencyto.2008.08.016. Cancer Genet Cytogenet. 2009. PMID: 19061776

On the karyotypic origin and evolution of cancer cells.

Nicholson JM, Duesberg P. Nicholson JM, et al. Cancer Genet Cytogenet. 2009 Oct 15;194(2):96-110. doi: 10.1016/j.cancergencyto.2009.06.008. Cancer Genet Cytogenet. 2009. PMID: 19781442

Specific clones of spontaneously evolving karyotypes generate individuality of cancers.

Fabarius A, Li R, Yerganian G, Hehlmann R, Duesberg P. Fabarius A, et al. Cancer Genet Cytogenet. 2008 Jan 15;180(2):89-99. doi: 10.1016/j.cancergencyto.2007.10.006. Cancer Genet Cytogenet. 2008. PMID: 18206533

Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells.

Duesberg P, Fabarius A, Hehlmann R. Duesberg P, et al. IUBMB Life. 2004 Feb;56(2):65-81. doi: 10.1080/15216540410001667902. IUBMB Life. 2004. PMID: 15085930 Free article. Review.

Immortality of cancers: a consequence of inherent karyotypic variations and selections for autonomy.

Duesberg P, McCormack A. Duesberg P, et al. Cell Cycle. 2013 Mar 1;12(5):783-802. doi: 10.4161/cc.23720. Epub 2013 Feb 6. Cell Cycle. 2013. PMID: 23388461 Free PMC article.

Transgenic oncogenes induce oncogene-independent cancers with individual karyotypes and phenotypes.

Klein A, Li N, Nicholson JM, McCormack AA, Graessmann A, Duesberg P. Klein A, et al. Cancer Genet Cytogenet. 2010 Jul 15;200(2):79-99. doi: 10.1016/j.cancergencyto.2010.04.008. Cancer Genet Cytogenet. 2010. PMID: 20620590

Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells.

Li R, Hehlman R, Sachs R, Duesberg P. Li R, et al. Cancer Genet Cytogenet. 2005 Nov;163(1):44-56. doi: 10.1016/j.cancergencyto.2005.05.003. Cancer Genet Cytogenet. 2005. PMID: 16271955

Aneuploidy, the somatic mutation that makes cancer a species of its own.

Duesberg P, Rasnick D. Duesberg P, et al. Cell Motil Cytoskeleton. 2000 Oct;47(2):81-107. doi: 10.1002/1097-0169(200010)47:2<81::AID-CM1>3.0.CO;2-#. Cell Motil Cytoskeleton. 2000. PMID: 11013390 Review.

How aneuploidy may cause cancer and genetic instability.

Duesberg P, Rasnick D, Li R, Winters L, Rausch C, Hehlmann R. Duesberg P, et al. Anticancer Res. 1999 Nov-Dec;19(6A):4887-906. Anticancer Res. 1999. PMID: 10697602 Review.

Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1.

Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PA. Grigorova M, et al. Cytogenet Genome Res. 2004;104(1-4):333-40. doi: 10.1159/000077512. Cytogenet Genome Res. 2004. PMID: 15162061

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