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Items: 1 to 20 of 278

1.

Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease.

Doukas J, Eide L, Stebbins K, Racanelli-Layton A, Dellamary L, Martin M, Dneprovskaia E, Noronha G, Soll R, Wrasidlo W, Acevedo LM, Cheresh DA.

J Pharmacol Exp Ther. 2009 Mar;328(3):758-65. doi: 10.1124/jpet.108.144311. Epub 2008 Dec 4.

2.

p38alpha-selective mitogen-activated protein kinase inhibitor SD-282 reduces inflammation in a subchronic model of tobacco smoke-induced airway inflammation.

Medicherla S, Fitzgerald MF, Spicer D, Woodman P, Ma JY, Kapoun AM, Chakravarty S, Dugar S, Protter AA, Higgins LS.

J Pharmacol Exp Ther. 2008 Mar;324(3):921-9. Epub 2007 Dec 4.

3.
4.

New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy.

Onoue S, Misaka S, Kawabata Y, Yamada S.

Expert Opin Drug Deliv. 2009 Aug;6(8):793-811. doi: 10.1517/17425240903089310. Review.

PMID:
19558334
5.

Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma?

Beeh KM, Beier J.

Clin Exp Allergy. 2006 Feb;36(2):142-57. Review.

PMID:
16433851
6.

The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation.

Takeda M, Ito W, Tanabe M, Ueki S, Kihara J, Kato H, Tanigai T, Kayaba H, Sasaki T, Chihara J.

Int Arch Allergy Immunol. 2010;152 Suppl 1:90-5. doi: 10.1159/000312132. Epub 2010 Jun 4. Review.

PMID:
20523070
7.

Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease.

Woodside DG, Vanderslice P.

BioDrugs. 2008;22(2):85-100. Review.

PMID:
18345706
8.

Effect of adenosine A2A receptor activation in murine models of respiratory disorders.

Bonneau O, Wyss D, Ferretti S, Blaydon C, Stevenson CS, Trifilieff A.

Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L1036-43. Epub 2005 Dec 9.

9.

Adenosine signaling in asthma and chronic obstructive pulmonary disease.

Mohsenin A, Blackburn MR.

Curr Opin Pulm Med. 2006 Jan;12(1):54-9. Review.

PMID:
16357580
10.

Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future.

Chung KF, Caramori G, Adcock IM.

Eur J Clin Pharmacol. 2009 Sep;65(9):853-71. doi: 10.1007/s00228-009-0682-z. Epub 2009 Jun 26. Review.

PMID:
19557399
11.

Allergic airway hyperresponsiveness, inflammation, and remodeling do not develop in phosphoinositide 3-kinase gamma-deficient mice.

Takeda M, Ito W, Tanabe M, Ueki S, Kato H, Kihara J, Tanigai T, Chiba T, Yamaguchi K, Kayaba H, Imai Y, Okuyama K, Ohno I, Sasaki T, Chihara J.

J Allergy Clin Immunol. 2009 Apr;123(4):805-12. doi: 10.1016/j.jaci.2008.11.047. Epub 2009 Feb 20.

PMID:
19232703
12.

PI 3-kinase inhibition: a therapeutic target for respiratory disease.

Finan PM, Thomas MJ.

Biochem Soc Trans. 2004 Apr;32(Pt 2):378-82. Review.

PMID:
15046612
13.

Selectin antagonists : therapeutic potential in asthma and COPD.

Romano SJ.

Treat Respir Med. 2005;4(2):85-94. Review.

PMID:
15813660
14.

Rho kinase as a therapeutic target in the treatment of asthma and chronic obstructive pulmonary disease.

Fernandes LB, Henry PJ, Goldie RG.

Ther Adv Respir Dis. 2007 Oct;1(1):25-33. doi: 10.1177/1753465807080740. Review.

PMID:
19124345
15.

Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD.

Caramori G, Adcock IM, Ito K.

Curr Opin Investig Drugs. 2004 Nov;5(11):1141-7. Review.

PMID:
15573863
16.

Immunology of asthma and chronic obstructive pulmonary disease.

Barnes PJ.

Nat Rev Immunol. 2008 Mar;8(3):183-92. doi: 10.1038/nri2254. Epub 2008 Feb 15. Review.

PMID:
18274560
17.

Anti-TNF-alpha therapies in chronic obstructive pulmonary diseases.

Antoniu SA, Mihaltan F, Ulmeanu R.

Expert Opin Investig Drugs. 2008 Aug;17(8):1203-11. doi: 10.1517/13543784.17.8.1203 . Review.

PMID:
18616416
18.

[Bronchial asthma and chronic obstructive pulmonary disease with acute exacerbation: preclinical differential diagnostic and emergency treatment].

Friege B, Friege L, Pelz J, Weber M, von Spiegel T, Schröder S.

Anaesthesist. 2009 Jun;58(6):611-22. doi: 10.1007/s00101-009-1536-x. Review. German.

PMID:
19424670
19.

Pharmacological treatment in asthma and COPD.

Hoshino T, Toda R, Aizawa H.

Allergol Int. 2009 Sep;58(3):341-6. doi: 10.2332/allergolint.09-RAI-0117. Epub 2009 Jul 25. Review.

20.

New anti-inflammatory therapies and targets for asthma and chronic obstructive pulmonary disease.

Belvisi MG, Hele DJ, Birrell MA.

Expert Opin Ther Targets. 2004 Aug;8(4):265-85. Review.

PMID:
15268623
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