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Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734.

Herrero AB, Astudillo AM, Balboa MA, Cuevas C, Balsinde J, Moreno S.

Cancer Res. 2008 Dec 1;68(23):9779-87. doi: 10.1158/0008-5472.CAN-08-1981.


Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation.

Uchida Y, Hama H, Alderson NL, Douangpanya S, Wang Y, Crumrine DA, Elias PM, Holleran WM.

J Biol Chem. 2007 May 4;282(18):13211-9. Epub 2007 Mar 12.


The human FA2H gene encodes a fatty acid 2-hydroxylase.

Alderson NL, Rembiesa BM, Walla MD, Bielawska A, Bielawski J, Hama H.

J Biol Chem. 2004 Nov 19;279(47):48562-8. Epub 2004 Aug 27.


Hydroxylation state of fatty acid and long-chain base moieties of sphingolipid determine the sensitivity to growth inhibition due to AUR1 repression in Saccharomyces cerevisiae.

Tani M, Kuge O.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):673-8. doi: 10.1016/j.bbrc.2011.11.138. Epub 2011 Dec 7.


FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain.

Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H.

J Lipid Res. 2006 Dec;47(12):2772-80. Epub 2006 Sep 23.


Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p.

Haak D, Gable K, Beeler T, Dunn T.

J Biol Chem. 1997 Nov 21;272(47):29704-10.


Mechanism of selectivity of an angiogenesis inhibitor from screening a genome-wide set of Saccharomyces cerevisiae deletion strains.

Dilda PJ, Don AS, Tanabe KM, Higgins VJ, Allen JD, Dawes IW, Hogg PJ.

J Natl Cancer Inst. 2005 Oct 19;97(20):1539-47.


Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells.

Alderson NL, Hama H.

J Lipid Res. 2009 Jun;50(6):1203-8. doi: 10.1194/jlr.M800666-JLR200. Epub 2009 Jan 22.


Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses.

Nagano M, Takahara K, Fujimoto M, Tsutsumi N, Uchimiya H, Kawai-Yamada M.

Plant Physiol. 2012 Jul;159(3):1138-48. doi: 10.1104/pp.112.199547. Epub 2012 May 25.


Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae.

Grilley MM, Stock SD, Dickson RC, Lester RL, Takemoto JY.

J Biol Chem. 1998 May 1;273(18):11062-8.


Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2.

Matias AC, Pedroso N, Teodoro N, Marinho HS, Antunes F, Nogueira JM, Herrero E, Cyrne L.

Free Radic Biol Med. 2007 Nov 15;43(10):1458-65. Epub 2007 Aug 15.


Deletion of OSH3 gene confers resistance against ISP-1 in Saccharomyces cerevisiae.

Yano T, Inukai M, Isono F.

Biochem Biophys Res Commun. 2004 Feb 27;315(1):228-34.


Mutants of Saccharomyces cerevisiae deficient in acyl-CoA synthetases secrete fatty acids due to interrupted fatty acid recycling.

Scharnewski M, Pongdontri P, Mora G, Hoppert M, Fulda M.

FEBS J. 2008 Jun;275(11):2765-78. doi: 10.1111/j.1742-4658.2008.06417.x. Epub 2008 Apr 16.


Genetic determinants of mitochondrial response to arsenic in yeast Saccharomyces cerevisiae.

Vujcic M, Shroff M, Singh KK.

Cancer Res. 2007 Oct 15;67(20):9740-9.


Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis.

Kemmer D, McHardy LM, Hoon S, Rebérioux D, Giaever G, Nislow C, Roskelley CD, Roberge M.

BMC Microbiol. 2009 Jan 14;9:9. doi: 10.1186/1471-2180-9-9.

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