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Results: 1 to 20 of 122

1.

ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.

Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL.

Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.

PMID:
19027009
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Bile salt excretory pump: biology and pathobiology.

Suchy FJ, Ananthanarayanan M.

J Pediatr Gastroenterol Nutr. 2006 Jul;43 Suppl 1:S10-6. Review.

PMID:
16819395
[PubMed - indexed for MEDLINE]
3.

Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1.

Alvarez L, Jara P, Sánchez-Sabaté E, Hierro L, Larrauri J, Díaz MC, Camarena C, De la Vega A, Frauca E, López-Collazo E, Lapunzina P.

Hum Mol Genet. 2004 Oct 15;13(20):2451-60. Epub 2004 Aug 18.

PMID:
15317749
[PubMed - indexed for MEDLINE]
Free Article
4.

Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity.

Chen F, Ananthanarayanan M, Emre S, Neimark E, Bull LN, Knisely AS, Strautnieks SS, Thompson RJ, Magid MS, Gordon R, Balasubramanian N, Suchy FJ, Shneider BL.

Gastroenterology. 2004 Mar;126(3):756-64.

PMID:
14988830
[PubMed - indexed for MEDLINE]
5.

Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters.

Hoeke MO, Plass JR, Heegsma J, Geuken M, van Rijsbergen D, Baller JF, Kuipers F, Moshage H, Jansen PL, Faber KN.

Hepatology. 2009 Jan;49(1):151-9. doi: 10.1002/hep.22661.

PMID:
19111018
[PubMed - indexed for MEDLINE]
6.

Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064.

Martínez-Fernández P, Hierro L, Jara P, Alvarez L.

Am J Physiol Gastrointest Liver Physiol. 2009 May;296(5):G1119-29. doi: 10.1152/ajpgi.90371.2008. Epub 2009 Feb 19.

PMID:
19228886
[PubMed - indexed for MEDLINE]
Free Article
7.

Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.

Groen A, Kunne C, Jongsma G, van den Oever K, Mok KS, Petruzzelli M, Vrins CL, Bull L, Paulusma CC, Oude Elferink RP.

Gastroenterology. 2008 Jun;134(7):2091-100. doi: 10.1053/j.gastro.2008.02.097. Epub 2008 Mar 8.

PMID:
18466903
[PubMed - indexed for MEDLINE]
8.

The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.

Frankenberg T, Miloh T, Chen FY, Ananthanarayanan M, Sun AQ, Balasubramaniyan N, Arias I, Setchell KD, Suchy FJ, Shneider BL.

Hepatology. 2008 Dec;48(6):1896-905. doi: 10.1002/hep.22431.

PMID:
18668687
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor.

Deng R, Yang D, Yang J, Yan B.

J Pharmacol Exp Ther. 2006 Apr;317(1):317-25. Epub 2005 Dec 21.

PMID:
16371446
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.

Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP.

Hepatology. 2006 Jul;44(1):195-204.

PMID:
16799980
[PubMed - indexed for MEDLINE]
11.

ATPase Class I Type 8B Member 1 and protein kinase C zeta induce the expression of the canalicular bile salt export pump in human hepatocytes.

Chen F, Ellis E, Strom SC, Shneider BL.

Pediatr Res. 2010 Feb;67(2):183-7. doi: 10.1203/PDR.0b013e3181c2df16.

PMID:
19809379
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity.

Yu J, Lo JL, Huang L, Zhao A, Metzger E, Adams A, Meinke PT, Wright SD, Cui J.

J Biol Chem. 2002 Aug 30;277(35):31441-7. Epub 2002 Jun 6.

PMID:
12052824
[PubMed - indexed for MEDLINE]
Free Article
13.

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP.

J Biol Chem. 2009 Apr 10;284(15):9947-54. doi: 10.1074/jbc.M808667200. Epub 2009 Feb 19.

PMID:
19228692
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

Ananthanarayanan M, Balasubramanian N, Makishima M, Mangelsdorf DJ, Suchy FJ.

J Biol Chem. 2001 Aug 3;276(31):28857-65. Epub 2001 May 31.

PMID:
11387316
[PubMed - indexed for MEDLINE]
Free Article
15.

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.

Verhulst PM, van der Velden LM, Oorschot V, van Faassen EE, Klumperman J, Houwen RH, Pomorski TG, Holthuis JC, Klomp LW.

Hepatology. 2010 Jun;51(6):2049-60. doi: 10.1002/hep.23586.

PMID:
20512993
[PubMed - indexed for MEDLINE]
16.

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump.

Plass JR, Mol O, Heegsma J, Geuken M, Faber KN, Jansen PL, Müller M.

Hepatology. 2002 Mar;35(3):589-96.

PMID:
11870371
[PubMed - indexed for MEDLINE]
17.

Progressive familial intrahepatic cholestasis type 1.

Paulusma CC, Elferink RP, Jansen PL.

Semin Liver Dis. 2010 May;30(2):117-24. doi: 10.1055/s-0030-1253221. Epub 2010 Apr 26. Review.

PMID:
20422494
[PubMed - indexed for MEDLINE]
18.

Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice.

Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD.

Toxicol Sci. 2009 Jul;110(1):47-60. doi: 10.1093/toxsci/kfp094. Epub 2009 Apr 30.

PMID:
19407337
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1.

Folmer DE, van der Mark VA, Ho-Mok KS, Oude Elferink RP, Paulusma CC.

Hepatology. 2009 Nov;50(5):1597-605. doi: 10.1002/hep.23158.

PMID:
19731236
[PubMed - indexed for MEDLINE]
20.

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP.

Gastroenterology. 2011 Nov;141(5):1927-37.e1-4. doi: 10.1053/j.gastro.2011.07.042. Epub 2011 Aug 4.

PMID:
21820390
[PubMed - indexed for MEDLINE]
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