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Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice.

Singh SV, Powolny AA, Stan SD, Xiao D, Arlotti JA, Warin R, Hahm ER, Marynowski SW, Bommareddy A, Potter DM, Dhir R.

Cancer Res. 2008 Nov 15;68(22):9503-11. doi: 10.1158/0008-5472.CAN-08-1677.


Garlic constituent diallyl trisulfide suppresses x-linked inhibitor of apoptosis protein in prostate cancer cells in culture and in vivo.

Kim SH, Bommareddy A, Singh SV.

Cancer Prev Res (Phila). 2011 Jun;4(6):897-906. doi: 10.1158/1940-6207.CAPR-10-0323. Epub 2011 Mar 16.


Transcriptional repression and inhibition of nuclear translocation of androgen receptor by diallyl trisulfide in human prostate cancer cells.

Stan SD, Singh SV.

Clin Cancer Res. 2009 Aug 1;15(15):4895-903. doi: 10.1158/1078-0432.CCR-09-0512. Epub 2009 Jul 21.


Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.

Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH.

Cancer Res. 2009 Mar 1;69(5):2117-25. doi: 10.1158/0008-5472.CAN-08-3502. Epub 2009 Feb 17.


Diallyl trisulfide suppresses growth of PC-3 human prostate cancer xenograft in vivo in association with Bax and Bak induction.

Xiao D, Lew KL, Kim YA, Zeng Y, Hahm ER, Dhir R, Singh SV.

Clin Cancer Res. 2006 Nov 15;12(22):6836-43.


Garlic constituent diallyl trisulfide induced apoptosis in MCF7 human breast cancer cells.

Malki A, El-Saadani M, Sultan AS.

Cancer Biol Ther. 2009 Nov;8(22):2175-85. Epub 2009 Nov 22.


Plumbagin inhibits prostate cancer development in TRAMP mice via targeting PKCĪµ, Stat3 and neuroendocrine markers.

Hafeez BB, Zhong W, Mustafa A, Fischer JW, Witkowsky O, Verma AK.

Carcinogenesis. 2012 Dec;33(12):2586-92. doi: 10.1093/carcin/bgs291. Epub 2012 Sep 13.


Stage-specific inhibitory effects and associated mechanisms of silibinin on tumor progression and metastasis in transgenic adenocarcinoma of the mouse prostate model.

Raina K, Rajamanickam S, Singh RP, Deep G, Chittezhath M, Agarwal R.

Cancer Res. 2008 Aug 15;68(16):6822-30. doi: 10.1158/0008-5472.CAN-08-1332.


Suppression of prostate carcinogenesis by dietary supplementation of celecoxib in transgenic adenocarcinoma of the mouse prostate model.

Gupta S, Adhami VM, Subbarayan M, MacLennan GT, Lewin JS, Hafeli UO, Fu P, Mukhtar H.

Cancer Res. 2004 May 1;64(9):3334-43.


Diallyl trisulfide inhibits activation of signal transducer and activator of transcription 3 in prostate cancer cells in culture and in vivo.

Chandra-Kuntal K, Singh SV.

Cancer Prev Res (Phila). 2010 Nov;3(11):1473-83. doi: 10.1158/1940-6207.CAPR-10-0123. Epub 2010 Oct 19.


Diallyl trisulfide induces apoptosis and inhibits proliferation of A549 cells in vitro and in vivo.

Li W, Tian H, Li L, Li S, Yue W, Chen Z, Qi L, Hu W, Zhu Y, Hao B, Gao C, Si L, Gao F.

Acta Biochim Biophys Sin (Shanghai). 2012 Jul;44(7):577-83. doi: 10.1093/abbs/gms033. Epub 2012 May 17.


Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms.

Shankar S, Chen Q, Ganapathy S, Singh KP, Srivastava RK.

Mol Cancer Ther. 2008 Aug;7(8):2328-38. doi: 10.1158/1535-7163.MCT-08-0216.


E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse.

Wechter WJ, Leipold DD, Murray ED Jr, Quiggle D, McCracken JD, Barrios RS, Greenberg NM.

Cancer Res. 2000 Apr 15;60(8):2203-8.


Diallyl trisulfide selectively causes Bax- and Bak-mediated apoptosis in human lung cancer cells.

Xiao D, Zeng Y, Hahm ER, Kim YA, Ramalingam S, Singh SV.

Environ Mol Mutagen. 2009 Apr;50(3):201-12. doi: 10.1002/em.20431.


Apigenin inhibits prostate cancer progression in TRAMP mice via targeting PI3K/Akt/FoxO pathway.

Shukla S, Bhaskaran N, Babcook MA, Fu P, Maclennan GT, Gupta S.

Carcinogenesis. 2014 Feb;35(2):452-60. doi: 10.1093/carcin/bgt316. Epub 2013 Sep 25.


Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

Powolny AA, Bommareddy A, Hahm ER, Normolle DP, Beumer JH, Nelson JB, Singh SV.

J Natl Cancer Inst. 2011 Apr 6;103(7):571-84. doi: 10.1093/jnci/djr029. Epub 2011 Feb 17.


Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice.

Raina K, Singh RP, Agarwal R, Agarwal C.

Cancer Res. 2007 Jun 15;67(12):5976-82.

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