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Items: 1 to 20 of 93


Rad50 is dispensable for the maintenance and viability of postmitotic tissues.

Adelman CA, De S, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):483-92. doi: 10.1128/MCB.01525-08. Epub 2008 Nov 10.


The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.


DNA damage signaling in hematopoietic cells: a role for Mre11 complex repair of topoisomerase lesions.

Morales M, Liu Y, Laiakis EC, Morgan WF, Nimer SD, Petrini JH.

Cancer Res. 2008 Apr 1;68(7):2186-93. doi: 10.1158/0008-5472.CAN-07-2355.


Division of labor: DNA repair and the cell cycle specific functions of the Mre11 complex.

Adelman CA, Petrini JH.

Cell Cycle. 2009 May 15;8(10):1510-4. Epub 2009 May 10.


The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.

Ciapponi L, Cenci G, Ducau J, Flores C, Johnson-Schlitz D, Gorski MM, Engels WR, Gatti M.

Curr Biol. 2004 Aug 10;14(15):1360-6.


Disruption of telomere maintenance by depletion of the MRE11/RAD50/NBS1 complex in cells that use alternative lengthening of telomeres.

Zhong ZH, Jiang WQ, Cesare AJ, Neumann AA, Wadhwa R, Reddel RR.

J Biol Chem. 2007 Oct 5;282(40):29314-22. Epub 2007 Aug 9.


The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.

Ciapponi L, Cenci G, Gatti M.

Genetics. 2006 Jul;173(3):1447-54. Epub 2006 Apr 30.


Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombination.

Delmas S, Shunburne L, Ngo HP, Allers T.

PLoS Genet. 2009 Jul;5(7):e1000552. doi: 10.1371/journal.pgen.1000552. Epub 2009 Jul 10.


MRE11/RAD50/NBS1: complex activities.

Assenmacher N, Hopfner KP.

Chromosoma. 2004 Oct;113(4):157-66. Epub 2004 Aug 10. Review.


Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.

He J, Shi LZ, Truong LN, Lu CS, Razavian N, Li Y, Negrete A, Shiloach J, Berns MW, Wu X.

J Biol Chem. 2012 Sep 14;287(38):31747-56. doi: 10.1074/jbc.M112.384750. Epub 2012 Jul 25.


Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends.

Trujillo KM, Roh DH, Chen L, Van Komen S, Tomkinson A, Sung P.

J Biol Chem. 2003 Dec 5;278(49):48957-64. Epub 2003 Sep 30.


The Aspergillus nidulans sldI(RAD50) gene interacts with bimE(APC1), a homologue of an anaphase-promoting complex subunit.

Malavazi I, Lima JF, von Zeska Kress Fagundes MR, Efimov VP, de Souza Goldman MH, Goldman GH.

Mol Microbiol. 2005 Jul;57(1):222-37.


Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang.

Samper E, Goytisolo FA, Slijepcevic P, van Buul PP, Blasco MA.

EMBO Rep. 2000 Sep;1(3):244-52.


The Rad50 hook domain is a critical determinant of Mre11 complex functions.

Wiltzius JJ, Hohl M, Fleming JC, Petrini JH.

Nat Struct Mol Biol. 2005 May;12(5):403-7. Epub 2005 Apr 24.


Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex.

Almond JR, Stohr BA, Panigrahi AK, Albrecht DW, Nelson SW, Kreuzer KN.

Genetics. 2013 Nov;195(3):739-55. doi: 10.1534/genetics.113.154872. Epub 2013 Aug 26.


Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair.

Hartsuiker E, Vaessen E, Carr AM, Kohli J.

EMBO J. 2001 Dec 3;20(23):6660-71.

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