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The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.

Nilsson J, Yekezare M, Minshull J, Pines J.

Nat Cell Biol. 2008 Dec;10(12):1411-20. doi: 10.1038/ncb1799. Epub 2008 Nov 9.


APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation.

Ge S, Skaar JR, Pagano M.

Cell Cycle. 2009 Jan 1;8(1):167-71. Epub 2009 Jan 11.


The spindle checkpoint functions of Mad3 and Mad2 depend on a Mad3 KEN box-mediated interaction with Cdc20-anaphase-promoting complex (APC/C).

Sczaniecka M, Feoktistova A, May KM, Chen JS, Blyth J, Gould KL, Hardwick KG.

J Biol Chem. 2008 Aug 22;283(34):23039-47. doi: 10.1074/jbc.M803594200. Epub 2008 Jun 13.


BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.

Tipton AR, Wang K, Link L, Bellizzi JJ, Huang H, Yen T, Liu ST.

J Biol Chem. 2011 Jun 17;286(24):21173-9. doi: 10.1074/jbc.M111.238543. Epub 2011 Apr 27.


Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint.

van Zon W, Wolthuis RM.

Biochem Soc Trans. 2010 Feb;38(Pt 1):72-7. doi: 10.1042/BST0380072. Review.


Role of phosphorylation of Cdc20 in p31(comet)-stimulated disassembly of the mitotic checkpoint complex.

Miniowitz-Shemtov S, Eytan E, Ganoth D, Sitry-Shevah D, Dumin E, Hershko A.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8056-60. doi: 10.1073/pnas.1204081109. Epub 2012 May 7.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner.

Lara-Gonzalez P, Scott MI, Diez M, Sen O, Taylor SS.

J Cell Sci. 2011 Dec 15;124(Pt 24):4332-45. doi: 10.1242/jcs.094763. Epub 2011 Dec 22.


Under arrest in mitosis: Cdc20 dies twice.

Fry AM, Yamano H.

Nat Cell Biol. 2008 Dec;10(12):1385-7. doi: 10.1038/ncb1208-1385.


APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.

Mansfeld J, Collin P, Collins MO, Choudhary JS, Pines J.

Nat Cell Biol. 2011 Sep 18;13(10):1234-43. doi: 10.1038/ncb2347.


How cyclin A destruction escapes the spindle assembly checkpoint.

Di Fiore B, Pines J.

J Cell Biol. 2010 Aug 23;190(4):501-9. doi: 10.1083/jcb.201001083.


Roles of different pools of the mitotic checkpoint complex and the mechanisms of their disassembly.

Eytan E, Sitry-Shevah D, Teichner A, Hershko A.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10568-73. doi: 10.1073/pnas.1308928110. Epub 2013 Jun 10.


Orderly inactivation of the key checkpoint protein mitotic arrest deficient 2 (MAD2) during mitotic progression.

Ma HT, Poon RY.

J Biol Chem. 2011 Apr 15;286(15):13052-9. doi: 10.1074/jbc.M110.201897. Epub 2011 Feb 18.


Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation.

Izawa D, Pines J.

J Cell Biol. 2012 Oct 1;199(1):27-37. doi: 10.1083/jcb.201205170. Epub 2012 Sep 24.


Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint.

Xia G, Luo X, Habu T, Rizo J, Matsumoto T, Yu H.

EMBO J. 2004 Aug 4;23(15):3133-43. Epub 2004 Jul 15.


Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

Kulukian A, Han JS, Cleveland DW.

Dev Cell. 2009 Jan;16(1):105-17. doi: 10.1016/j.devcel.2008.11.005.


The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.

Foster SA, Morgan DO.

Mol Cell. 2012 Sep 28;47(6):921-32. doi: 10.1016/j.molcel.2012.07.031. Epub 2012 Aug 30.


Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18419-24. doi: 10.1073/pnas.1213438109. Epub 2012 Oct 22.

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