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18989516,18989515,14999195,18215609,23086784,17461704,17122800,18477734,16729401,16479474,18327396,18319394,17560866,18193674,20701931,17562671,21183532,19006861,20027714,19877380,15204241,19006862,18359601,17917618,19884296,20542796,18929236,18657680,19138236,19132185,19575095,18406994,19387970,17976413,9424739,21472149,17932593,15152137,19355808,19952295,18171566,19249409,18092705,17710074,17267456,18353757,16763985,20020231,18392216,11759618,15824298,20062939,17026890,19187982,19670304,21304575,17696811,19840557,19888529,19064015,9834303,20818903,18327417,19699846,19124633,19367228,19105763,20925012,22997933,17912162,18840379,19166708,21518675,20837828,20513596,18422094,21238889,20839914,19281914,20650831,19769880,21147290,20548817,15788977,18434736,9869155,17950790,12324559,19801028,19258833,19473668,18666844,18641090,18177451,21098354,16716103,12530435,19159853,19355809,20828343,18091407,19213065,21517891,20059711,12638475,19472347,20029203,18688203,18198244,16441469,12232817,14517922,12735045,23790600,17667883,21282540,21560471,21374797,18547948,19478692,21514251,18418272,19081397,19198009,19089929,21215136,16516705,12389343,19041120,19166711,17194433,19299635,19695357,9834311,18797530,20157843,19695362,14999185,18754964,19179814,11933375,18774049,25809373,19451347,19185647,19166710,20045378,18983063,19892050,16428578,15114389,17551994,18829070,19493391,18393143,19232433,18060240,19477870,19069017,18602531,26718519,12523247,19085914,19342841,19213064,25178500,20387255,10399252,19379060,18174449,12230645,19681112,19077618,19098058,17724837,24446037,16286733,10745607,20551395,18848144,20889291,11776303,19707287,20062940,18567389,9597990,21519218,17973854,20866007,20516248,22728913,23474139,19726525,12955672,16102022,18508982,18506123,18060243,10598366,18398246,18226874,11794970,21282200,17096154,15883598,19742434,19780217,20038286,18093204,18276815,12603879,16204751,21285051,22801999,18302308,18568182,25729838,19915994,15493411,12075203,20557312,10373716,18041892,30281043,17124390,8529856,21518951,20006120,11770173,20831051,20152547,18549922,19356003,20438416,18294567,19780216,11496890,16103464,16186871,17574453,19132214,17698822,16973010,21242480,19299634,17555117,11735194,18434718,20443337,12008695,9619133,17909706,18701053,23876586,18281911,17255089,10223873,10155114,18677297,25467434,24528617,21212258,23026666,19888528,20508897,17165174,18265459,23166979,25467021,25076696,17917620,20551394,30052888,17903151,19342758,16287777,11718493,11877857,18259210,31553201,17803581,10232088,22996583,15489086,9104903,19874336,19644482,16804280,21125040,25964963,9577715,27640616,24067509,18449411,19457954,17089258,12697786,26764084,9822070,26944654,24046139,21514003,16598554,19527984,18358365,16103468,21839960,18575244,18647224,16139331,21387196,26002833,14587449,15233569,20304905,19907815,29768312,20672399,16109256,9396638,15095933,15660026,3830391,16711198,21491738,21463909,15383487,11948280,20223172,24898695,16567572,11002460,17989545,23797323,18371464,26202836,12376447,22684153,21304293,20013333,36974469,16528965,21207341,16294291,16776405,20884441,18765833,18655916,18289411,11794968,18822448,32651889,29074533,12674158,20965214,17823214,16274734,20202816,20043423,27055051,21481934,17938292,20843406,19935784,19880273,18098333,18653823,16814064,21315212,18325715,23306435,29939512,24898316,23076988,25585230,18474393,10799628,23567764,28375131,11876339,31942967,25163307,15898147,20124137,19463322,16733604,23328783,21335142,27521729,10828222,16818131,21130962,16791939,25477329,17678798,21941228,17023437,18544305,15972875,22153625,22143472,25577431,18669548,23233633,20439812,18227457,18544543,20529097,17710072,25518419,26763466,20801857,22164941,18508853,17089906,12638472,15101021,30153372,17223469,10560451,9672482,15800233,18578065,10905133,25264642,18306836,22734794,26318509,16377474,18776974,8578495,22056593,10776658,20394161,20602345,29362190,21108185,16804940,18075484,7565850,11719405,27687385,25955251,29781069,28012566,29602462,23621139,20664898,21809526,23967446,20387566,15646683,17911490,17917616,16294616,15846242,18403776,18937631,11139799,9167482,6504795,20447945,20635715,18407000,11804975,22340431,18476453,21087754,18713119,28445573,24550198,20401285,16271406,26703284,1579955,16874903,21909806,9822058,20538142,31909430,23485833,25440397,24774401,16913028,15178502,19299633,29346127,18326440,15846858,9173004,10428244,17164056,22118041,20030667,10614194,10502200,21709123,24585795,21301651,15878819,18160579,26823456,24642558,6390223,23736138,30354448,24902976,33534976,8898540,16165308,11739325,15082424,16585402,28981961,11965312,18482660,27235831,16013658,29501323,21715717,16821566,15208796,18074530,25337986,20431946,16906242,17569677,18953049,18924058,19122243,24932554,24096684,25817954,16620400,16867846,16670595,20584204,24215186,11796858,21982924,24957306,29523011,16200921,17678799,17261693,18989068,23241055,10992548,15168894,20518002,24277754,11797723,16038710,30711164,21922225,12040596,12500607,33112125,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Contra: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regimen in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'. Not for everybody.

Roldán V, Marín F. Roldán V, et al. Thromb Haemost. 2008 Nov;100(5):754-5. Thromb Haemost. 2008. PMID: 18989516 No abstract available.

Pro: 'Antithrombotic therapy with warfarin, aspirin and clopidogrel is the recommended regime in anticoagulated patients who present with an acute coronary syndrome and/or undergo percutaneous coronary interventions'.

Rubboli A, Halperin JL. Rubboli A, et al. Thromb Haemost. 2008 Nov;100(5):752-3. Thromb Haemost. 2008. PMID: 18989515 No abstract available.

Safety and efficacy of aspirin, clopidogrel, and warfarin after coronary stent placement in patients with an indication for anticoagulation.

Orford JL, Fasseas P, Melby S, Burger K, Steinhubl SR, Holmes DR, Berger PB. Orford JL, et al. Am Heart J. 2004 Mar;147(3):463-7. doi: 10.1016/j.ahj.2003.06.004. Am Heart J. 2004. PMID: 14999195

Discharge antithrombotic strategies among patients with acute coronary syndrome previously on warfarin anticoagulation: physician practice in the CRUSADE registry.

Wang TY, Robinson LA, Ou FS, Roe MT, Ohman EM, Gibler WB, Smith SC Jr, Peterson ED, Becker RC. Wang TY, et al. Am Heart J. 2008 Feb;155(2):361-8. doi: 10.1016/j.ahj.2007.09.003. Epub 2007 Oct 25. Am Heart J. 2008. PMID: 18215609

Triple antithrombotic therapy following an acute coronary syndrome: prevalence, outcomes and prognostic utility of the HAS-BLED score.

Smith JG, Wieloch M, Koul S, Braun OÖ, Lumsden J, Rydell E, Ohman J, Scherstén F, Svensson PJ, van der Pals J. Smith JG, et al. EuroIntervention. 2012 Oct;8(6):672-8. doi: 10.4244/EIJV8I6A105. EuroIntervention. 2012. PMID: 23086784 Free article.

Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy.

DeEugenio D, Kolman L, DeCaro M, Andrel J, Chervoneva I, Duong P, Lam L, McGowan C, Lee G, DeCaro M, Ruggiero N, Singhal S, Greenspon A. DeEugenio D, et al. Pharmacotherapy. 2007 May;27(5):691-6. doi: 10.1592/phco.27.5.691. Pharmacotherapy. 2007. PMID: 17461704

Drug insight: antithrombotic therapy after percutaneous coronary intervention in patients with an indication for anticoagulation.

Helft G, Gilard M, Le Feuvre C, Zaman AG. Helft G, et al. Nat Clin Pract Cardiovasc Med. 2006 Dec;3(12):673-80. doi: 10.1038/ncpcardio0712. Nat Clin Pract Cardiovasc Med. 2006. PMID: 17122800 Review.

Aspirin, clopidogrel, and warfarin: is the combination appropriate and effective or inappropriate and too dangerous?

Hermosillo AJ, Spinler SA. Hermosillo AJ, et al. Ann Pharmacother. 2008 Jun;42(6):790-805. doi: 10.1345/aph.1K591. Epub 2008 May 13. Ann Pharmacother. 2008. PMID: 18477734 Review.

Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding.

Khurram Z, Chou E, Minutello R, Bergman G, Parikh M, Naidu S, Wong SC, Hong MK. Khurram Z, et al. J Invasive Cardiol. 2006 Apr;18(4):162-4. J Invasive Cardiol. 2006. PMID: 16729401

[Recommendations for peri-procedural thrombocyte aggregation inhibition].

Sauer H, Leschke M. Sauer H, et al. Dtsch Med Wochenschr. 2006 Feb 24;131(8):400-2. doi: 10.1055/s-2006-932534. Dtsch Med Wochenschr. 2006. PMID: 16479474 German. No abstract available.

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