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1.

Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach.

Reimer K, Hopp M, Zenz M, Maier C, Holzer P, Mikus G, Bosse B, Smith K, Buschmann-Kramm C, Leyendecker P.

Pharmacology. 2009;83(1):10-7. doi: 10.1159/000165778. Epub 2008 Oct 28. Review.

PMID:
18957874
2.

Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its management.

Holzer P, Ahmedzai SH, Niederle N, Leyendecker P, Hopp M, Bosse B, Spohr I, Reimer K.

J Opioid Manag. 2009 May-Jun;5(3):145-51. Review.

PMID:
19662924
3.
4.

Analgesic efficacy and safety of oxycodone in combination with naloxone as prolonged release tablets in patients with moderate to severe chronic pain.

Vondrackova D, Leyendecker P, Meissner W, Hopp M, Szombati I, Hermanns K, Ruckes C, Weber S, Grothe B, Fleischer W, Reimer K.

J Pain. 2008 Dec;9(12):1144-54. doi: 10.1016/j.jpain.2008.06.014. Epub 2008 Aug 16.

PMID:
18708300
5.

The role of opioid receptor antagonists in the treatment of opioid-induced constipation: a review.

Leppert W.

Adv Ther. 2010 Oct;27(10):714-30. doi: 10.1007/s12325-010-0063-0. Epub 2010 Aug 26. Review.

PMID:
20799006
6.

A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation.

Meissner W, Leyendecker P, Mueller-Lissner S, Nadstawek J, Hopp M, Ruckes C, Wirz S, Fleischer W, Reimer K.

Eur J Pain. 2009 Jan;13(1):56-64. doi: 10.1016/j.ejpain.2008.06.012. Epub 2008 Aug 31.

PMID:
18762438
8.

Patient assessment of a novel therapeutic approach for the treatment of severe, chronic pain.

Nadstawek J, Leyendecker P, Hopp M, Ruckes C, Wirz S, Fleischer W, Reimer K.

Int J Clin Pract. 2008 Aug;62(8):1159-67. doi: 10.1111/j.1742-1241.2008.01820.x.

9.

Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial.

Löwenstein O, Leyendecker P, Hopp M, Schutter U, Rogers PD, Uhl R, Bond S, Kremers W, Nichols T, Krain B, Reimer K.

Expert Opin Pharmacother. 2009 Mar;10(4):531-43. doi: 10.1517/14656560902796798 .

PMID:
19243306
10.

Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain.

Simpson K, Leyendecker P, Hopp M, Müller-Lissner S, Löwenstein O, De Andrés J, Troy Ferrarons J, Bosse B, Krain B, Nichols T, Kremers W, Reimer K.

Curr Med Res Opin. 2008 Dec;24(12):3503-12. doi: 10.1185/03007990802584454 .

PMID:
19032132
11.

Prolonged-release oxycodone/naloxone in the treatment of neuropathic pain - results from a large observational study.

Hermanns K, Junker U, Nolte T.

Expert Opin Pharmacother. 2012 Feb;13(3):299-311. doi: 10.1517/14656566.2012.648615. Epub 2012 Jan 6.

PMID:
22224497
12.

High doses of oxycodone-naloxone combination may provide poor analgesia.

Mercadante S, Ferrera P, Adile C.

Support Care Cancer. 2011 Sep;19(9):1471-2. doi: 10.1007/s00520-011-1205-x. Epub 2011 Jun 9.

PMID:
21656338
13.
14.

[Quality of life suffers much in constipation. Plea for an intelligent pain therapy].

[No authors listed]

MMW Fortschr Med. 2006 Aug 31;148(35-36):55. German. No abstract available.

PMID:
16995370
15.

Oxycodone + naloxone: choose morphine and optimal laxative therapy instead.

[No authors listed]

Prescrire Int. 2013 Jan;22(134):10-1.

PMID:
23367675
16.

[A year of chronic pain with Targin--experience from daily practice. Interview with Dr. Patricia Fehlmann].

Fehlmann P.

Rev Med Suisse. 2011 Jun 29;7(301):preceding 1414. French. No abstract available.

PMID:
21815498
17.

Prolonged-release oxycodone/naloxone in nonmalignant pain: single-center study in patients with constipation.

Gatti A, Casali M, Lazzari M, Tufaro G, Gafforio P, Silvestri C, Marcassa C, Sabato AF.

Adv Ther. 2013 Jan;30(1):41-59. doi: 10.1007/s12325-012-0074-0. Epub 2012 Dec 21.

PMID:
23269562
18.
19.

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain.

Sandner-Kiesling A, Leyendecker P, Hopp M, Tarau L, Lejcko J, Meissner W, Sevcik P, Hakl M, Hrib R, Uhl R, Dürr H, Reimer K.

Int J Clin Pract. 2010 May;64(6):763-74. doi: 10.1111/j.1742-1241.2010.02360.x. Epub 2010 Mar 29.

20.

Fixed combination of oxycodone with naloxone: a new way to prevent and treat opioid-induced constipation.

Mueller-Lissner S.

Adv Ther. 2010 Sep;27(9):581-90. doi: 10.1007/s12325-010-0057-y. Epub 2010 Aug 11. Review.

PMID:
20714946
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