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Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure.

Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Köhler R, Wulff H.

Mol Pharmacol. 2009 Feb;75(2):281-95. doi: 10.1124/mol.108.051425. Epub 2008 Oct 27.


Activation of KCa3.1 by SKA-31 induces arteriolar dilatation and lowers blood pressure in normo- and hypertensive connexin40-deficient mice.

Radtke J, Schmidt K, Wulff H, Köhler R, de Wit C.

Br J Pharmacol. 2013 Sep;170(2):293-303. doi: 10.1111/bph.12267.


Improvement of endothelium-dependent vasodilations by SKA-31 and SKA-20, activators of small- and intermediate-conductance Ca2+ -activated K+ -channels.

Hasenau AL, Nielsen G, Morisseau C, Hammock BD, Wulff H, Köhler R.

Acta Physiol (Oxf). 2011 Sep;203(1):117-26. doi: 10.1111/j.1748-1716.2010.02240.x. Epub 2011 Mar 1.


New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.

Coleman N, Brown BM, Oliván-Viguera A, Singh V, Olmstead MM, Valero MS, Köhler R, Wulff H.

Mol Pharmacol. 2014 Sep;86(3):342-57. doi: 10.1124/mol.114.093286. Epub 2014 Jun 23.


Pharmacological activation of KCa3.1/KCa2.3 channels produces endothelial hyperpolarization and lowers blood pressure in conscious dogs.

Damkjaer M, Nielsen G, Bodendiek S, Staehr M, Gramsbergen JB, de Wit C, Jensen BL, Simonsen U, Bie P, Wulff H, Köhler R.

Br J Pharmacol. 2012 Jan;165(1):223-34. doi: 10.1111/j.1476-5381.2011.01546.x.


Novel phenolic inhibitors of small/intermediate-conductance Ca²⁺-activated K⁺ channels, KCa3.1 and KCa2.3.

Oliván-Viguera A, Valero MS, Murillo MD, Wulff H, García-Otín AL, Arbonés-Mainar JM, Köhler R.

PLoS One. 2013;8(3):e58614. doi: 10.1371/journal.pone.0058614. Epub 2013 Mar 14.


Endothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discovery.

Grgic I, Kaistha BP, Hoyer J, Köhler R.

Br J Pharmacol. 2009 Jun;157(4):509-26. doi: 10.1111/j.1476-5381.2009.00132.x. Epub 2009 Mar 19. Review.


A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo.

Oliván-Viguera A, Valero MS, Coleman N, Brown BM, Laría C, Murillo MD, Gálvez JA, Díaz-de-Villegas MD, Wulff H, Badorrey R, Köhler R.

Mol Pharmacol. 2015 Feb;87(2):338-48. doi: 10.1124/mol.114.095745. Epub 2014 Dec 2.


Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo.

Wölfle SE, Schmidt VJ, Hoyer J, Köhler R, de Wit C.

Cardiovasc Res. 2009 Jun 1;82(3):476-83. doi: 10.1093/cvr/cvp060. Epub 2009 Feb 13.


Pulmonary hypertension in wild type mice and animals with genetic deficit in KCa2.3 and KCa3.1 channels.

Wandall-Frostholm C, Skaarup LM, Sadda V, Nielsen G, Hedegaard ER, Mogensen S, Köhler R, Simonsen U.

PLoS One. 2014 May 23;9(5):e97687. doi: 10.1371/journal.pone.0097687. eCollection 2014.


Inhibition of Myogenic Tone in Rat Cremaster and Cerebral Arteries by SKA-31, an Activator of Endothelial KCa2.3 and KCa3.1 Channels.

Mishra RC, Wulff H, Hill MA, Braun AP.

J Cardiovasc Pharmacol. 2015 Jul;66(1):118-27. doi: 10.1097/FJC.0000000000000252.


Laminar shear stress upregulates endothelial Ca²⁺-activated K⁺ channels KCa2.3 and KCa3.1 via a Ca²⁺/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.

Takai J, Santu A, Zheng H, Koh SD, Ohta M, Filimban LM, Lemaître V, Teraoka R, Jo H, Miura H.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H484-93. doi: 10.1152/ajpheart.00642.2012. Epub 2013 Jun 21.


Endothelial small-conductance and intermediate-conductance KCa channels: an update on their pharmacology and usefulness as cardiovascular targets.

Wulff H, Köhler R.

J Cardiovasc Pharmacol. 2013 Feb;61(2):102-12. doi: 10.1097/FJC.0b013e318279ba20. Review.


Pharmacological activation of small conductance calcium-activated potassium channels with naphtho[1,2-d]thiazol-2-ylamine decreases guinea pig detrusor smooth muscle excitability and contractility.

Parajuli SP, Soder RP, Hristov KL, Petkov GV.

J Pharmacol Exp Ther. 2012 Jan;340(1):114-23. doi: 10.1124/jpet.111.186213. Epub 2011 Oct 14.


Modulators of small- and intermediate-conductance calcium-activated potassium channels and their therapeutic indications.

Wulff H, Kolski-Andreaco A, Sankaranarayanan A, Sabatier JM, Shakkottai V.

Curr Med Chem. 2007;14(13):1437-57. Review.


Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.

Köhler R, Kaistha BP, Wulff H.

Expert Opin Ther Targets. 2010 Feb;14(2):143-55. doi: 10.1517/14728220903540257. Review.


Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels.

Lambertsen KL, Gramsbergen JB, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R.

PLoS One. 2012;7(10):e47744. doi: 10.1371/journal.pone.0047744. Epub 2012 Oct 15.


SK channel-selective opening by SKA-31 induces hyperpolarization and decreases contractility in human urinary bladder smooth muscle.

Soder RP, Parajuli SP, Hristov KL, Rovner ES, Petkov GV.

Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R155-63. doi: 10.1152/ajpregu.00363.2012. Epub 2012 Nov 21.


Advanced glycation end products impair K(Ca)3.1- and K(Ca)2.3-mediated vasodilatation via oxidative stress in rat mesenteric arteries.

Zhao LM, Wang Y, Ma XZ, Wang NP, Deng XL.

Pflugers Arch. 2014 Feb;466(2):307-17. doi: 10.1007/s00424-013-1324-y. Epub 2013 Jul 20.


Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice.

Köhler R, Ruth P.

Pflugers Arch. 2010 May;459(6):969-76. doi: 10.1007/s00424-010-0819-z. Epub 2010 Mar 28. Review.

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