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Items: 1 to 20 of 105

1.

BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD.

Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396.

2.

BH3 domains other than Bim and Bid can directly activate Bax/Bak.

Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.

J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1.

3.

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.

Shamas-Din A, Bindner S, Chi X, Leber B, Andrews DW, Fradin C.

Biochem J. 2015 May 1;467(3):495-505. doi: 10.1042/BJ20141291.

PMID:
25714678
4.

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9.

5.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.

6.

Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

Kim H, Tu HC, Ren D, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH.

Mol Cell. 2009 Nov 13;36(3):487-99. doi: 10.1016/j.molcel.2009.09.030.

7.

Structural biology of the Bcl-2 family of proteins.

Petros AM, Olejniczak ET, Fesik SW.

Biochim Biophys Acta. 2004 Mar 1;1644(2-3):83-94. Review.

8.

B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.

Renault TT, Elkholi R, Bharti A, Chipuk JE.

J Biol Chem. 2014 Sep 19;289(38):26481-91. doi: 10.1074/jbc.M114.569632. Epub 2014 Aug 5.

9.

Structural insight into BH3 domain binding of vaccinia virus antiapoptotic F1L.

Campbell S, Thibault J, Mehta N, Colman PM, Barry M, Kvansakul M.

J Virol. 2014 Aug;88(15):8667-77. doi: 10.1128/JVI.01092-14. Epub 2014 May 21.

10.

Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.

Robin AY, Krishna Kumar K, Westphal D, Wardak AZ, Thompson GV, Dewson G, Colman PM, Czabotar PE.

Cell Death Dis. 2015 Jul 9;6:e1809. doi: 10.1038/cddis.2015.141.

11.

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.

Mol Cell Biol. 2002 Jun;22(11):3577-89.

12.

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.

Jabbour AM, Heraud JE, Daunt CP, Kaufmann T, Sandow J, O'Reilly LA, Callus BA, Lopez A, Strasser A, Vaux DL, Ekert PG.

Cell Death Differ. 2009 Apr;16(4):555-63. doi: 10.1038/cdd.2008.179. Epub 2008 Dec 12.

13.

Targeting Bax interaction sites reveals that only homo-oligomerization sites are essential for its activation.

Peng R, Tong JS, Li H, Yue B, Zou F, Yu J, Zhang L.

Cell Death Differ. 2013 May;20(5):744-54. doi: 10.1038/cdd.2013.4. Epub 2013 Feb 8.

14.

Molecular dynamics study of segment peptides of Bax, Bim, and Mcl-1 BH3 domain of the apoptosis-regulating proteins bound to the anti-apoptotic Mcl-1 protein.

Zhao RN, Fan S, Han JG, Liu G.

J Biomol Struct Dyn. 2015;33(5):1067-81. doi: 10.1080/07391102.2014.929028. Epub 2014 Jun 30.

PMID:
24865469
15.

BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes.

Terrones O, Etxebarria A, Landajuela A, Landeta O, Antonsson B, Basañez G.

J Biol Chem. 2008 Mar 21;283(12):7790-803. doi: 10.1074/jbc.M708814200. Epub 2008 Jan 14.

16.

The vaccinia virus protein F1L interacts with Bim and inhibits activation of the pro-apoptotic protein Bax.

Taylor JM, Quilty D, Banadyga L, Barry M.

J Biol Chem. 2006 Dec 22;281(51):39728-39. Epub 2006 Oct 30.

17.

BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.

Weber A, Paschen SA, Heger K, Wilfling F, Frankenberg T, Bauerschmitt H, Seiffert BM, Kirschnek S, Wagner H, Häcker G.

J Cell Biol. 2007 May 21;177(4):625-36.

18.

Mapping the specific cytoprotective interaction of humanin with the pro-apoptotic protein bid.

Choi J, Zhai D, Zhou X, Satterthwait A, Reed JC, Marassi FM.

Chem Biol Drug Des. 2007 Nov;70(5):383-92. Epub 2007 Oct 10.

19.

NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.

Yao S, Westphal D, Babon JJ, Thompson GV, Robin AY, Adams JM, Colman PM, Czabotar PE.

Arch Biochem Biophys. 2014 Mar 1;545:33-43. doi: 10.1016/j.abb.2014.01.003. Epub 2014 Jan 13.

PMID:
24434006
20.

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD.

Mol Cell. 2015 Mar 5;57(5):873-86. doi: 10.1016/j.molcel.2015.01.014. Epub 2015 Feb 12.

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