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Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo.

Pudupakam RS, Huang YW, Opriessnig T, Halbur PG, Pierson FW, Meng XJ.

J Virol. 2009 Jan;83(1):384-95. doi: 10.1128/JVI.01854-08. Epub 2008 Oct 22.


Mutational analysis of the hypervariable region of hepatitis e virus reveals its involvement in the efficiency of viral RNA replication.

Pudupakam RS, Kenney SP, Córdoba L, Huang YW, Dryman BA, Leroith T, Pierson FW, Meng XJ.

J Virol. 2011 Oct;85(19):10031-40. doi: 10.1128/JVI.00763-11. Epub 2011 Jul 20.


Three amino acid mutations (F51L, T59A, and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation.

Córdoba L, Huang YW, Opriessnig T, Harral KK, Beach NM, Finkielstein CV, Emerson SU, Meng XJ.

J Virol. 2011 Jun;85(11):5338-49. doi: 10.1128/JVI.02278-10. Epub 2011 Mar 30.


Construction and characterization of infectious cDNA clones of a chicken strain of hepatitis E virus (HEV), avian HEV.

Huang FF, Pierson FW, Toth TE, Meng XJ.

J Gen Virol. 2005 Sep;86(Pt 9):2585-93.


Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs.

Córdoba L, Feagins AR, Opriessnig T, Cossaboom CM, Dryman BA, Huang YW, Meng XJ.

J Gen Virol. 2012 Oct;93(Pt 10):2183-94. doi: 10.1099/vir.0.043711-0. Epub 2012 Jul 25.


Long-term shedding of hepatitis E virus in the feces of pigs infected naturally, born to sows with and without maternal antibodies.

Kanai Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K.

J Med Virol. 2010 Jan;82(1):69-76. doi: 10.1002/jmv.21647.


Cross-species infection of specific-pathogen-free pigs by a genotype 4 strain of human hepatitis E virus.

Feagins AR, Opriessnig T, Huang YW, Halbur PG, Meng XJ.

J Med Virol. 2008 Aug;80(8):1379-86. doi: 10.1002/jmv.21223.


The PSAP motif within the ORF3 protein of an avian strain of the hepatitis E virus is not critical for viral infectivity in vivo but plays a role in virus release.

Kenney SP, Pudupakam RS, Huang YW, Pierson FW, LeRoith T, Meng XJ.

J Virol. 2012 May;86(10):5637-46. doi: 10.1128/JVI.06711-11. Epub 2012 Mar 21.


Systematic pathogenesis and replication of avian hepatitis E virus in specific-pathogen-free adult chickens.

Billam P, Huang FF, Sun ZF, Pierson FW, Duncan RB, Elvinger F, Guenette DK, Toth TE, Meng XJ.

J Virol. 2005 Mar;79(6):3429-37. Erratum in: J Virol. 2006 Jul;80(13):6721.


Construction of an infectious cDNA clone of avian hepatitis E virus (avian HEV) recovered from a clinically healthy chicken in the United States and characterization of its pathogenicity in specific-pathogen-free chickens.

Kwon HM, LeRoith T, Pudupakam RS, Pierson FW, Huang YW, Dryman BA, Meng XJ.

Vet Microbiol. 2011 Jan 27;147(3-4):310-9. doi: 10.1016/j.vetmic.2010.07.016. Epub 2010 Jul 22.


Hepatitis E virus infection among animals in northern India: an unlikely source of human disease.

Shukla P, Chauhan UK, Naik S, Anderson D, Aggarwal R.

J Viral Hepat. 2007 May;14(5):310-7.


Infectivity of a genotype 4 hepatitis E virus cDNA clone by intrahepatic inoculation of laboratory rats.

Zhu Y, Yu X, Zhang Y, Ni Y, Si F, Yu R, Dong S, Huang Y, Li Z.

Vet Microbiol. 2013 Oct 25;166(3-4):405-11. doi: 10.1016/j.vetmic.2013.06.021. Epub 2013 Jul 9.


Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs.

Feagins AR, Córdoba L, Sanford BJ, Dryman BA, Huang YW, LeRoith T, Emerson SU, Meng XJ.

Virus Res. 2011 Mar;156(1-2):141-6. doi: 10.1016/j.virusres.2010.12.011. Epub 2010 Dec 30.


Human and swine hepatitis E viruses from Western India belong to different genotypes.

Arankalle VA, Chobe LP, Joshi MV, Chadha MS, Kundu B, Walimbe AM.

J Hepatol. 2002 Mar;36(3):417-25.

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