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Items: 1 to 20 of 177

1.

Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.

Fan J, Fahr B, Stockett D, Chan E, Cheeti S, Serafimova I, Lu Y, Pham P, Walker DH, Hoch U, Choong IC.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6236-9. doi: 10.1016/j.bmcl.2008.09.099. Epub 2008 Oct 2.

PMID:
18926699
2.

Novel bisaryl substituted thiazoles and oxazoles as highly potent and selective peroxisome proliferator-activated receptor delta agonists.

Epple R, Cow C, Xie Y, Azimioara M, Russo R, Wang X, Wityak J, Karanewsky DS, Tuntland T, Nguyêñ-Trân VT, Cuc Ngo C, Huang D, Saez E, Spalding T, Gerken A, Iskandar M, Seidel HM, Tian SS.

J Med Chem. 2010 Jan 14;53(1):77-105. doi: 10.1021/jm9007399.

PMID:
19928766
3.

A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.

Choong IC, Serafimova I, Fan J, Stockett D, Chan E, Cheeti S, Lu Y, Fahr B, Pham P, Arkin MR, Walker DH, Hoch U.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5763-5. doi: 10.1016/j.bmcl.2008.09.073. Epub 2008 Sep 24.

PMID:
18842409
4.

Library synthesis and screening: 2,4-diphenylthiazoles and 2,4-diphenyloxazoles as potential novel prion disease therapeutics.

Heal W, Thompson MJ, Mutter R, Cope H, Louth JC, Chen B.

J Med Chem. 2007 Mar 22;50(6):1347-53. Epub 2007 Feb 17.

PMID:
17305326
5.

Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones.

Shi B, Blake AJ, Lewis W, Campbell IB, Judkins BD, Moody CJ.

J Org Chem. 2010 Jan 1;75(1):152-61. doi: 10.1021/jo902256r.

PMID:
19954177
6.

Substituted tetrahydropyrrolo[2,1-b]oxazol-5(6H)-ones and tetrahydropyrrolo[2,1-b]thiazol-5(6H)-ones as hypoglycemic agents.

Aicher TD, Balkan B, Bell PA, Brand LJ, Cheon SH, Deems RO, Fell JB, Fillers WS, Fraser JD, Gao J, Knorr DC, Kahle GG, Leone CL, Nadelson J, Simpson R, Smith HC.

J Med Chem. 1998 Nov 5;41(23):4556-66.

PMID:
9804695
7.

Combinatorial synthesis of oxazol-thiazole bis-heterocyclic compounds.

Murru S, Nefzi A.

ACS Comb Sci. 2014 Jan 13;16(1):39-45. doi: 10.1021/co400133a. Epub 2013 Dec 9.

PMID:
24295491
9.

Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs.

Guerra-Bubb JM, Bowers AA, Smith WB, Paranal R, Estiu G, Wiest O, Bradner JE, Williams RM.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):6025-8. doi: 10.1016/j.bmcl.2013.06.012. Epub 2013 Jun 18.

10.

Potent, novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC.

Kline T, Andersen NH, Harwood EA, Bowman J, Malanda A, Endsley S, Erwin AL, Doyle M, Fong S, Harris AL, Mendelsohn B, Mdluli K, Raetz CR, Stover CK, Witte PR, Yabannavar A, Zhu S.

J Med Chem. 2002 Jul 4;45(14):3112-29.

PMID:
12086497
11.

Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.

Zhao LX, Park JG, Moon YS, Basnet A, Choi J, Kim EK, Jeong TC, Jahng Y, Lee ES.

Farmaco. 2004 May;59(5):381-8.

PMID:
15120317
12.

Solid-phase synthesis of 1,3-azole-based peptides and peptidomimetics.

Biron E, Chatterjee J, Kessler H.

Org Lett. 2006 May 25;8(11):2417-20.

PMID:
16706540
13.

Hypoglycemic activity of a series of alpha-alkylthio and alpha-alkoxy carboxylic acids related to ciglitazone.

Hulin B, Newton LS, Lewis DM, Genereux PE, Gibbs EM, Clark DA.

J Med Chem. 1996 Sep 27;39(20):3897-907.

PMID:
8831756
14.

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7.

Zheng W, Degterev A, Hsu E, Yuan J, Yuan C.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):4932-5. doi: 10.1016/j.bmcl.2008.08.058. Epub 2008 Aug 22.

PMID:
18768316
15.

Anxiolytic sedatives. 1. Synthesis and pharmacology of benzo[6,7]-1,4-diazepino[5,4-b]oxazole derivatives and analogs.

Miyadera T, Terada A, Fukunaga M, Kawano Y, Kamioka T, Tamura C, Takagi H, Tachikawa R.

J Med Chem. 1971 Jun;14(6):520-6. No abstract available.

PMID:
5091967
16.

Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity.

Mésangeau C, Narayanan S, Green AM, Shaikh J, Kaushal N, Viard E, Xu YT, Fishback JA, Poupaert JH, Matsumoto RR, McCurdy CR.

J Med Chem. 2008 Mar 13;51(5):1482-6. doi: 10.1021/jm701357m. Epub 2008 Feb 16.

PMID:
18278854
17.

alpha 2-adrenoreceptors profile modulation. 2. Biphenyline analogues as tools for selective activation of the alpha 2C-subtype.

Gentili F, Ghelfi F, Giannella M, Piergentili A, Pigini M, Quaglia W, Vesprini C, Crassous PA, Paris H, Carrieri A.

J Med Chem. 2004 Dec 2;47(25):6160-73.

PMID:
15566287
18.

4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase.

Alexander R, Balasundaram A, Batchelor M, Brookings D, Crépy K, Crabbe T, Deltent MF, Driessens F, Gill A, Harris S, Hutchinson G, Kulisa C, Merriman M, Mistry P, Parton T, Turner J, Whitcombe I, Wright S.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4316-20. doi: 10.1016/j.bmcl.2008.06.076. Epub 2008 Jun 28.

PMID:
18625552
19.

Synthesis and biological activity of anticoccidial agents: 5,6-diarylimidazo[2,1-b][1,3]thiazoles.

Scribner A, Meitz S, Fisher M, Wyvratt M, Leavitt P, Liberator P, Gurnett A, Brown C, Mathew J, Thompson D, Schmatz D, Biftu T.

Bioorg Med Chem Lett. 2008 Oct 1;18(19):5263-7. doi: 10.1016/j.bmcl.2008.08.063. Epub 2008 Aug 22.

PMID:
18789686
20.

Nickel-catalyzed direct arylation of azoles with aryl bromides.

Hachiya H, Hirano K, Satoh T, Miura M.

Org Lett. 2009 Apr 16;11(8):1737-40. doi: 10.1021/ol900159a.

PMID:
19301925
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