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Items: 1 to 20 of 267

1.

Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer.

Provenzano PP, Inman DR, Eliceiri KW, Beggs HE, Keely PJ.

Am J Pathol. 2008 Nov;173(5):1551-65. doi: 10.2353/ajpath.2008.080308. Epub 2008 Oct 9.

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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression.

Lahlou H, Sanguin-Gendreau V, Zuo D, Cardiff RD, McLean GW, Frame MC, Muller WJ.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20302-7. Epub 2007 Dec 3.

4.

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

Pylayeva Y, Gillen KM, Gerald W, Beggs HE, Reichardt LF, Giancotti FG.

J Clin Invest. 2009 Feb;119(2):252-66. doi: 10.1172/JCI37160. Epub 2009 Jan 19.

5.

Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation.

van Nimwegen MJ, Verkoeijen S, van Buren L, Burg D, van de Water B.

Cancer Res. 2005 Jun 1;65(11):4698-706.

6.

Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK.

Lofgren KA, Ostrander JH, Housa D, Hubbard GK, Locatelli A, Bliss RL, Schwertfeger KL, Lange CA.

Breast Cancer Res. 2011 Sep 17;13(5):R89. doi: 10.1186/bcr2946.

7.

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation.

van Miltenburg MH, van Nimwegen MJ, Tijdens I, Lalai R, Kuiper R, Klarenbeek S, Schouten PC, de Vries A, Jonkers J, van de Water B.

Br J Cancer. 2014 May 27;110(11):2747-55. doi: 10.1038/bjc.2014.219. Epub 2014 May 8.

8.

Signal transduction by focal adhesion kinase in cancer.

Zhao J, Guan JL.

Cancer Metastasis Rev. 2009 Jun;28(1-2):35-49. doi: 10.1007/s10555-008-9165-4. Review.

PMID:
19169797
9.

Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth.

Chang LC, Huang CH, Cheng CH, Chen BH, Chen HC.

J Biomed Sci. 2005;12(4):571-85. Epub 2005 Nov 10.

PMID:
16132110
10.

Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo.

Fan H, Zhao X, Sun S, Luo M, Guan JL.

J Biol Chem. 2013 Feb 1;288(5):3322-33. doi: 10.1074/jbc.M112.420497. Epub 2012 Dec 19.

11.

Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis.

Marcotte R, Smith HW, Sanguin-Gendreau V, McDonough RV, Muller WJ.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2808-13. doi: 10.1073/pnas.1018861108. Epub 2011 May 31.

12.

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

Hochgräfe F, Zhang L, O'Toole SA, Browne BC, Pinese M, Porta Cubas A, Lehrbach GM, Croucher DR, Rickwood D, Boulghourjian A, Shearer R, Nair R, Swarbrick A, Faratian D, Mullen P, Harrison DJ, Biankin AV, Sutherland RL, Raftery MJ, Daly RJ.

Cancer Res. 2010 Nov 15;70(22):9391-401. doi: 10.1158/0008-5472.CAN-10-0911. Epub 2010 Sep 21.

13.

Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse.

Peng M, Ball-Kell SM, Tyner AL.

Cell Death Dis. 2015 Aug 6;6:e1848. doi: 10.1038/cddis.2015.210.

14.

p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis.

Cabodi S, Tinnirello A, Di Stefano P, Bisarò B, Ambrosino E, Castellano I, Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F, Turco E, Tarone G, Defilippi P.

Cancer Res. 2006 May 1;66(9):4672-80.

15.

Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-beta signaling and metastasis.

Wendt MK, Schiemann WP.

Breast Cancer Res. 2009;11(5):R68. doi: 10.1186/bcr2360. Epub .

16.

New concepts regarding focal adhesion kinase promotion of cell migration and proliferation.

Cox BD, Natarajan M, Stettner MR, Gladson CL.

J Cell Biochem. 2006 Sep 1;99(1):35-52. Review.

PMID:
16823799
17.

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

Walsh C, Tanjoni I, Uryu S, Tomar A, Nam JO, Luo H, Phillips A, Patel N, Kwok C, McMahon G, Stupack DG, Schlaepfer DD.

Cancer Biol Ther. 2010 May 15;9(10):778-90.

18.

Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis.

Luo M, Guan JL.

Cancer Lett. 2010 Mar 28;289(2):127-39. doi: 10.1016/j.canlet.2009.07.005. Epub 2009 Jul 29. Review.

19.

Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration.

Manso AM, Kang SM, Plotnikov SV, Thievessen I, Oh J, Beggs HE, Ross RS.

Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H627-38. doi: 10.1152/ajpheart.00444.2008. Epub 2009 Jan 9.

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