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Items: 1 to 20 of 197


Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model.

Bilousova TV, Dansie L, Ngo M, Aye J, Charles JR, Ethell DW, Ethell IM.

J Med Genet. 2009 Feb;46(2):94-102. doi: 10.1136/jmg.2008.061796. Epub 2008 Oct 3.


Long-lasting effects of minocycline on behavior in young but not adult Fragile X mice.

Dansie LE, Phommahaxay K, Okusanya AG, Uwadia J, Huang M, Rotschafer SE, Razak KA, Ethell DW, Ethell IM.

Neuroscience. 2013 Aug 29;246:186-98. doi: 10.1016/j.neuroscience.2013.04.058. Epub 2013 May 7.


The therapeutic effect of memantine through the stimulation of synapse formation and dendritic spine maturation in autism and fragile X syndrome.

Wei H, Dobkin C, Sheikh AM, Malik M, Brown WT, Li X.

PLoS One. 2012;7(5):e36981. doi: 10.1371/journal.pone.0036981. Epub 2012 May 15.


Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant.

Pop AS, Levenga J, de Esch CE, Buijsen RA, Nieuwenhuizen IM, Li T, Isaacs A, Gasparini F, Oostra BA, Willemsen R.

Psychopharmacology (Berl). 2014 Mar;231(6):1227-35. doi: 10.1007/s00213-012-2947-y. Epub 2012 Dec 21.


Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome.

Rotschafer SE, Trujillo MS, Dansie LE, Ethell IM, Razak KA.

Brain Res. 2012 Feb 23;1439:7-14. doi: 10.1016/j.brainres.2011.12.041. Epub 2011 Dec 31.


Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome.

Liu ZH, Chuang DM, Smith CB.

Int J Neuropsychopharmacol. 2011 Jun;14(5):618-30. doi: 10.1017/S1461145710000520. Epub 2010 May 25.


Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.

Han K, Chen H, Gennarino VA, Richman R, Lu HC, Zoghbi HY.

Hum Mol Genet. 2015 Apr 1;24(7):1813-23. doi: 10.1093/hmg/ddu595. Epub 2014 Nov 28.


Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen.

Henderson C, Wijetunge L, Kinoshita MN, Shumway M, Hammond RS, Postma FR, Brynczka C, Rush R, Thomas A, Paylor R, Warren ST, Vanderklish PW, Kind PC, Carpenter RL, Bear MF, Healy AM.

Sci Transl Med. 2012 Sep 19;4(152):152ra128.


Developmental characteristics of dendritic spines in the dentate gyrus of Fmr1 knockout mice.

Grossman AW, Aldridge GM, Lee KJ, Zeman MK, Jun CS, Azam HS, Arii T, Imoto K, Greenough WT, Rhyu IJ.

Brain Res. 2010 Oct 8;1355:221-7. doi: 10.1016/j.brainres.2010.07.090. Epub 2010 Aug 2.


Chronic metabotropic glutamate receptor 5 inhibition corrects local alterations of brain activity and improves cognitive performance in fragile X mice.

Michalon A, Bruns A, Risterucci C, Honer M, Ballard TM, Ozmen L, Jaeschke G, Wettstein JG, von Kienlin M, K√ľnnecke B, Lindemann L.

Biol Psychiatry. 2014 Feb 1;75(3):189-97. doi: 10.1016/j.biopsych.2013.05.038. Epub 2013 Jul 30.


Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome.

Pan F, Aldridge GM, Greenough WT, Gan WB.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17768-73. doi: 10.1073/pnas.1012496107. Epub 2010 Sep 22.


Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.

Dolan BM, Duron SG, Campbell DA, Vollrath B, Shankaranarayana Rao BS, Ko HY, Lin GG, Govindarajan A, Choi SY, Tonegawa S.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5671-6. doi: 10.1073/pnas.1219383110. Epub 2013 Mar 18.


Altered structural and functional synaptic plasticity with motor skill learning in a mouse model of fragile X syndrome.

Padmashri R, Reiner BC, Suresh A, Spartz E, Dunaevsky A.

J Neurosci. 2013 Dec 11;33(50):19715-23. doi: 10.1523/JNEUROSCI.2514-13.2013.


Reversal of activity-mediated spine dynamics and learning impairment in a mouse model of Fragile X syndrome.

Boda B, Mendez P, Boury-Jamot B, Magara F, Muller D.

Eur J Neurosci. 2014 Apr;39(7):1130-7. doi: 10.1111/ejn.12488.


High MMP-9 activity levels in fragile X syndrome are lowered by minocycline.

Dziembowska M, Pretto DI, Janusz A, Kaczmarek L, Leigh MJ, Gabriel N, Durbin-Johnson B, Hagerman RJ, Tassone F.

Am J Med Genet A. 2013 Aug;161A(8):1897-903. doi: 10.1002/ajmg.a.36023. Epub 2013 Jul 3.


Comprehensive analysis of ultrasonic vocalizations in a mouse model of fragile X syndrome reveals limited, call type specific deficits.

Roy S, Watkins N, Heck D.

PLoS One. 2012;7(9):e44816. doi: 10.1371/journal.pone.0044816. Epub 2012 Sep 11.


Fragile X mental retardation protein replacement restores hippocampal synaptic function in a mouse model of fragile X syndrome.

Zeier Z, Kumar A, Bodhinathan K, Feller JA, Foster TC, Bloom DC.

Gene Ther. 2009 Sep;16(9):1122-9. doi: 10.1038/gt.2009.83. Epub 2009 Jul 2.


Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.

Sidhu H, Dansie LE, Hickmott PW, Ethell DW, Ethell IM.

J Neurosci. 2014 Jul 23;34(30):9867-79. doi: 10.1523/JNEUROSCI.1162-14.2014.


Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome.

Spencer CM, Alekseyenko O, Serysheva E, Yuva-Paylor LA, Paylor R.

Genes Brain Behav. 2005 Oct;4(7):420-30.

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