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Results: 1 to 20 of 186

1.

Isolation of hyperactive mutants of mammalian target of rapamycin.

Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, Mizushima N, Maeda T.

J Biol Chem. 2008 Nov 14;283(46):31861-70. doi: 10.1074/jbc.M801546200. Epub 2008 Sep 23.

PMID:
18812319
[PubMed - indexed for MEDLINE]
Free Article
2.

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2.

Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM.

PLoS Biol. 2009 Feb 10;7(2):e38. doi: 10.1371/journal.pbio.1000038.

PMID:
19209957
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

PMID:
17599906
[PubMed - indexed for MEDLINE]
Free Article
4.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

PMID:
19995915
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Monitoring mammalian target of rapamycin (mTOR) activity.

Ikenoue T, Hong S, Inoki K.

Methods Enzymol. 2009;452:165-80. doi: 10.1016/S0076-6879(08)03611-2.

PMID:
19200882
[PubMed - indexed for MEDLINE]
6.

mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action.

Soliman GA, Acosta-Jaquez HA, Dunlop EA, Ekim B, Maj NE, Tee AR, Fingar DC.

J Biol Chem. 2010 Mar 12;285(11):7866-79. doi: 10.1074/jbc.M109.096222. Epub 2009 Dec 18.

PMID:
20022946
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.

Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.

Mol Cell Biol. 2009 Mar;29(6):1411-20. doi: 10.1128/MCB.00782-08. Epub 2008 Dec 29.

PMID:
19114562
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.

Acosta-Jaquez HA, Keller JA, Foster KG, Ekim B, Soliman GA, Feener EP, Ballif BA, Fingar DC.

Mol Cell Biol. 2009 Aug;29(15):4308-24. doi: 10.1128/MCB.01665-08. Epub 2009 Jun 1.

PMID:
19487463
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2.

Copp J, Manning G, Hunter T.

Cancer Res. 2009 Mar 1;69(5):1821-7. doi: 10.1158/0008-5472.CAN-08-3014. Epub 2009 Feb 24.

PMID:
19244117
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin.

Yu K, Toral-Barza L, Shi C, Zhang WG, Lucas J, Shor B, Kim J, Verheijen J, Curran K, Malwitz DJ, Cole DC, Ellingboe J, Ayral-Kaloustian S, Mansour TS, Gibbons JJ, Abraham RT, Nowak P, Zask A.

Cancer Res. 2009 Aug 1;69(15):6232-40. doi: 10.1158/0008-5472.CAN-09-0299. Epub 2009 Jul 7.

PMID:
19584280
[PubMed - indexed for MEDLINE]
Free Article
11.

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.

Int J Oncol. 2009 Oct;35(4):731-40.

PMID:
19724909
[PubMed - indexed for MEDLINE]
12.

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.

PMID:
23928304
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2.

Li W, Petrimpol M, Molle KD, Hall MN, Battegay EJ, Humar R.

Circ Res. 2007 Jan 5;100(1):79-87. Epub 2006 Nov 16.

PMID:
17110594
[PubMed - indexed for MEDLINE]
Free Article
14.

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation.

Wang L, Harris TE, Lawrence JC Jr.

J Biol Chem. 2008 Jun 6;283(23):15619-27. doi: 10.1074/jbc.M800723200. Epub 2008 Mar 27.

PMID:
18372248
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation.

Carrière A, Cargnello M, Julien LA, Gao H, Bonneil E, Thibault P, Roux PP.

Curr Biol. 2008 Sep 9;18(17):1269-77. doi: 10.1016/j.cub.2008.07.078. Epub 2008 Aug 21.

PMID:
18722121
[PubMed - indexed for MEDLINE]
Free Article
16.

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.

Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA.

Mol Cancer Ther. 2009 Apr;8(4):742-53. doi: 10.1158/1535-7163.MCT-08-0668.

PMID:
19372546
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

mTOR in renal cell cancer: modulator of tumor biology and therapeutic target.

Wysocki PJ.

Expert Rev Mol Diagn. 2009 Apr;9(3):231-41. doi: 10.1586/erm.09.8. Review.

PMID:
19379082
[PubMed - indexed for MEDLINE]
18.

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2.

Huang J, Dibble CC, Matsuzaki M, Manning BD.

Mol Cell Biol. 2008 Jun;28(12):4104-15. doi: 10.1128/MCB.00289-08. Epub 2008 Apr 14.

PMID:
18411301
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

deGraffenried LA, Friedrichs WE, Russell DH, Donzis EJ, Middleton AK, Silva JM, Roth RA, Hidalgo M.

Clin Cancer Res. 2004 Dec 1;10(23):8059-67.

PMID:
15585641
[PubMed - indexed for MEDLINE]
Free Article
20.

Evaluation of mTOR function by a gain-of-function approach.

Ohne Y, Takahara T, Maeda T.

Cell Cycle. 2009 Feb 15;8(4):573-9. Epub 2009 Feb 18.

PMID:
19182527
[PubMed - indexed for MEDLINE]
Free Article

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