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Items: 1 to 20 of 176


WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.

Christmann M, Tomicic MT, Gestrich C, Roos WP, Bohr VA, Kaina B.

DNA Repair (Amst). 2008 Dec 1;7(12):1999-2009. doi: 10.1016/j.dnarep.2008.08.008. Epub 2008 Oct 15.


Topotecan-triggered degradation of topoisomerase I is p53-dependent and impacts cell survival.

Tomicic MT, Christmann M, Kaina B.

Cancer Res. 2005 Oct 1;65(19):8920-6.


Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.

Aggarwal M, Sommers JA, Shoemaker RH, Brosh RM Jr.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30. doi: 10.1073/pnas.1006423108. Epub 2011 Jan 10.


Detection of topoisomerase inhibitor-induced DNA strand breaks and apoptosis by the alkaline comet assay.

Godard T, Deslandes E, Sichel F, Poul JM, Gauduchon P.

Mutat Res. 2002 Sep 26;520(1-2):47-56.


Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

Huelsenbeck SC, Schorr A, Roos WP, Huelsenbeck J, Henninger C, Kaina B, Fritz G.

J Biol Chem. 2012 Nov 9;287(46):38590-9. doi: 10.1074/jbc.M112.377903. Epub 2012 Sep 25.


Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone.

Smart DJ, Halicka HD, Schmuck G, Traganos F, Darzynkiewicz Z, Williams GM.

Mutat Res. 2008 May 10;641(1-2):43-7. doi: 10.1016/j.mrfmmm.2008.03.005. Epub 2008 Mar 25.


Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex.

Hofland K, Petersen BO, Falck J, Helin K, Jensen PB, Sehested M.

Clin Cancer Res. 2000 Apr;6(4):1488-97.


Topotecan-induced topoisomerase IIalpha expression increases the sensitivity of the CML cell line K562 to subsequent etoposide plus mitoxantrone treatment.

Chen S, Gomez SP, McCarley D, Mainwaring MG.

Cancer Chemother Pharmacol. 2002 May;49(5):347-55. Epub 2002 Mar 6.


Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.

Yang HL, Dong YB, Elliott MJ, Wong SL, McMasters KM.

Cancer Gene Ther. 2001 Apr;8(4):241-51.


Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.

Pichierri P, Franchitto A, Mosesso P, Proietti de Santis L, Balajee AS, Palitti F.

Mutat Res. 2000 Mar 20;459(2):123-33.


The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.

Mao FJ, Sidorova JM, Lauper JM, Emond MJ, Monnat RJ.

Cancer Res. 2010 Aug 15;70(16):6548-55. doi: 10.1158/0008-5472.CAN-10-0475. Epub 2010 Jul 27.


WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA.

Mol Biol Cell. 2008 Sep;19(9):3923-33. doi: 10.1091/mbc.E07-07-0698. Epub 2008 Jul 2.


Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway.

Aggarwal M, Banerjee T, Sommers JA, Iannascoli C, Pichierri P, Shoemaker RH, Brosh RM Jr.

Cancer Res. 2013 Sep 1;73(17):5497-507. doi: 10.1158/0008-5472.CAN-12-2975. Epub 2013 Jul 18.

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