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Items: 1 to 20 of 373

1.

Regulation of human dihydrofolate reductase activity and expression.

Abali EE, Skacel NE, Celikkaya H, Hsieh YC.

Vitam Horm. 2008;79:267-92. doi: 10.1016/S0083-6729(08)00409-3. Review.

PMID:
18804698
2.

Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.

Skacel N, Menon LG, Mishra PJ, Peters R, Banerjee D, Bertino JR, Abali EE.

J Biol Chem. 2005 Jun 17;280(24):22721-31. Epub 2005 Apr 6.

3.

Anticancer antifolates: current status and future directions.

McGuire JJ.

Curr Pharm Des. 2003;9(31):2593-613. Review.

PMID:
14529544
4.

Dihydrofolate reductase as a target for chemotherapy in parasites.

Gangjee A, Kurup S, Namjoshi O.

Curr Pharm Des. 2007;13(6):609-39. Review.

PMID:
17346178
5.

Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro.

Chu E, Takimoto CH, Voeller D, Grem JL, Allegra CJ.

Biochemistry. 1993 May 11;32(18):4756-60.

PMID:
8490020
6.

Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols.

Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF.

Drug Metab Dispos. 2008 Mar;36(3):508-16. Epub 2007 Dec 3.

7.

Molecular mechanisms of resistance to antifolates, a review.

Banerjee D, Ercikan-Abali E, Waltham M, Schnieders B, Hochhauser D, Li WW, Fan J, Gorlick R, Goker E, Bertino JR.

Acta Biochim Pol. 1995;42(4):457-64. Review.

8.

Translational autoregulation of thymidylate synthase and dihydrofolate reductase.

Tai N, Schmitz JC, Liu J, Lin X, Bailly M, Chen TM, Chu E.

Front Biosci. 2004 Sep 1;9:2521-6. Review.

PMID:
15353304
9.

Transcriptional regulation of the dihydrofolate reductase/rep-3 locus.

Schilling LJ, Farnham PJ.

Crit Rev Eukaryot Gene Expr. 1994;4(1):19-53. Review.

PMID:
7987046
10.
11.

Cancer research: from folate antagonism to molecular targets.

Bertino JR.

Best Pract Res Clin Haematol. 2009 Dec;22(4):577-82. doi: 10.1016/j.beha.2009.09.004. Review.

PMID:
19959110
12.

Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.

Li R, Sirawaraporn R, Chitnumsub P, Sirawaraporn W, Wooden J, Athappilly F, Turley S, Hol WG.

J Mol Biol. 2000 Jan 14;295(2):307-23.

PMID:
10623528
13.

Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.

Senkovich O, Schormann N, Chattopadhyay D.

Acta Crystallogr D Biol Crystallogr. 2009 Jul;65(Pt 7):704-16. doi: 10.1107/S090744490901230X. Epub 2009 Jun 20.

PMID:
19564691
14.

Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression.

Mayer-Kuckuk P, Banerjee D, Malhotra S, Doubrovin M, Iwamoto M, Akhurst T, Balatoni J, Bornmann W, Finn R, Larson S, Fong Y, Gelovani Tjuvajev J, Blasberg R, Bertino JR.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3400-5. Epub 2002 Mar 12.

15.

Lead discovery of inhibitors of the dihydrofolate reductase domain of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.

Toyoda T, Brobey RK, Sano G, Horii T, Tomioka N, Itai A.

Biochem Biophys Res Commun. 1997 Jun 27;235(3):515-9.

PMID:
9207187
16.

Tobacco budworm dihydrofolate reductase is a promising target for insecticide discovery.

Walker VK, Tyshenko MG, Kuiper MJ, Dargar RV, Yuhas DA, Cruickshank PA, Chaguturu R.

Eur J Biochem. 2000 Jan;267(2):394-403.

17.

Drosophila dihydrofolate reductase mutations confer antifolate resistance to mammalian cells.

Affleck JG, Al-Batayneh KM, Neumann K, Cole SP, Walker VK.

Eur J Pharmacol. 2006 Jan 4;529(1-3):71-8. Epub 2005 Dec 2.

PMID:
16325803
18.
19.

Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.

Schormann N, Senkovich O, Walker K, Wright DL, Anderson AC, Rosowsky A, Ananthan S, Shinkre B, Velu S, Chattopadhyay D.

Proteins. 2008 Dec;73(4):889-901. doi: 10.1002/prot.22115.

PMID:
18536013
20.
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