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Items: 1 to 20 of 153


The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration.

Chen D, Steele AD, Hutter G, Bruno J, Govindarajan A, Easlon E, Lin SJ, Aguzzi A, Lindquist S, Guarente L.

Exp Gerontol. 2008 Dec;43(12):1086-93. doi: 10.1016/j.exger.2008.08.050. Epub 2008 Aug 30.


Is Sirt1 a miracle bullet for longevity?

Imai S.

Aging Cell. 2007 Dec;6(6):735-7. Epub 2007 Oct 17.


Tissue-specific regulation of SIRT1 by calorie restriction.

Chen D, Bruno J, Easlon E, Lin SJ, Cheng HL, Alt FW, Guarente L.

Genes Dev. 2008 Jul 1;22(13):1753-7. doi: 10.1101/gad.1650608. Epub 2008 Jun 11.


SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH.

EMBO J. 2007 Jul 11;26(13):3169-79. Epub 2007 Jun 21.


SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD.

Aging Cell. 2014 Feb;13(1):193-6. doi: 10.1111/acel.12151. Epub 2013 Nov 19.


Linking sirtuins, IGF-I signaling, and starvation.

Longo VD.

Exp Gerontol. 2009 Jan-Feb;44(1-2):70-4. doi: 10.1016/j.exger.2008.06.005. Epub 2008 Jun 24. Review.


Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.

Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L.

Nature. 2004 Jun 17;429(6993):771-6. Epub 2004 Jun 2. Erratum in: Nature. 2004 Aug 19;430(7002):921.


Calorie restriction--the SIR2 connection.

Guarente L, Picard F.

Cell. 2005 Feb 25;120(4):473-82. Review.


[Effects of calorie restriction on SIRT1 expression in liver of nonalcoholic fatty liver disease: experiment with rats].

Chen LL, Deng XQ, Li NX.

Zhonghua Yi Xue Za Zhi. 2007 May 29;87(20):1434-7. Chinese.


Sirtuin regulation in calorie restriction.

Qiu X, Brown KV, Moran Y, Chen D.

Biochim Biophys Acta. 2010 Aug;1804(8):1576-83. doi: 10.1016/j.bbapap.2009.09.015. Epub 2009 Sep 24. Review.


Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.

Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM.

J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2.


Calorie restriction increases life span: a molecular mechanism.

Wolf G.

Nutr Rev. 2006 Feb;64(2 Pt 1):89-92. Review.


A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.

Gräff J, Kahn M, Samiei A, Gao J, Ota KT, Rei D, Tsai LH.

J Neurosci. 2013 May 22;33(21):8951-60. doi: 10.1523/JNEUROSCI.5657-12.2013.


Increase in activity during calorie restriction requires Sirt1.

Chen D, Steele AD, Lindquist S, Guarente L.

Science. 2005 Dec 9;310(5754):1641.


Calorie restriction, SIRT1 and metabolism: understanding longevity.

Bordone L, Guarente L.

Nat Rev Mol Cell Biol. 2005 Apr;6(4):298-305. Review.


Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction.

Cohen DE, Supinski AM, Bonkowski MS, Donmez G, Guarente LP.

Genes Dev. 2009 Dec 15;23(24):2812-7. doi: 10.1101/gad.1839209. Erratum in: Genes Dev. 2010 Mar 1;24(5):516.


Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo.

Smith JJ, Kenney RD, Gagne DJ, Frushour BP, Ladd W, Galonek HL, Israelian K, Song J, Razvadauskaite G, Lynch AV, Carney DP, Johnson RJ, Lavu S, Iffland A, Elliott PJ, Lambert PD, Elliston KO, Jirousek MR, Milne JC, Boss O.

BMC Syst Biol. 2009 Mar 10;3:31. doi: 10.1186/1752-0509-3-31.


Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK, Kaeberlein M.

Aging Cell. 2006 Dec;5(6):505-14.


Caloric restriction, SIRT1 and longevity.

Cantó C, Auwerx J.

Trends Endocrinol Metab. 2009 Sep;20(7):325-31. doi: 10.1016/j.tem.2009.03.008. Epub 2009 Aug 25. Review.


Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins.

Smith DL Jr, McClure JM, Matecic M, Smith JS.

Aging Cell. 2007 Oct;6(5):649-62. Epub 2007 Aug 15.

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