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TP508 (Chrysalin) reverses endothelial dysfunction and increases perfusion and myocardial function in hearts with chronic ischemia.

Fossum TW, Olszewska-Pazdrak B, Mertens MM, Makarski LA, Miller MW, Hein TW, Kuo L, Clubb F, Fuller GM, Carney DH.

J Cardiovasc Pharmacol Ther. 2008 Sep;13(3):214-25. doi: 10.1177/1074248408321468.


High-dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response.

Boodhwani M, Nakai Y, Voisine P, Feng J, Li J, Mieno S, Ramlawi B, Bianchi C, Laham R, Sellke FW.

Circulation. 2006 Jul 4;114(1 Suppl):I402-8.


Restoration of impaired endothelium-dependent coronary vasodilation in failing heart: role of eNOS phosphorylation and CGMP/cGK-I signaling.

Gill RM, Braz JC, Jin N, Etgen GJ, Shen W.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2782-90. Epub 2007 Feb 23.


Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction.

Voisine P, Li J, Bianchi C, Khan TA, Ruel M, Xu SH, Feng J, Rosinberg A, Malik T, Nakai Y, Sellke FW.

Circulation. 2005 Aug 30;112(9 Suppl):I202-7.


Coronary microvascular dysfunction in the setting of chronic ischemia is independent of arginase activity.

Sodha NR, Boodhwani M, Clements RT, Feng J, Xu SH, Sellke FW.

Microvasc Res. 2008 Mar;75(2):238-46. Epub 2007 Aug 16.


Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia.

Nakai Y, Voisine P, Bianchi C, Xu SH, Feng J, Malik T, Rosinberg A, Sellke FW.

Surgery. 2005 Aug;138(2):291-8.


Role of nitric oxide in the coupling of myocardial oxygen consumption and coronary vascular dynamics during pregnancy in the dog.

Williams JG, Rincon-Skinner T, Sun D, Wang Z, Zhang S, Zhang X, Hintze TH.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2479-86. Epub 2007 Jul 20.


Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome.

Elmadhun NY, Lassaletta AD, Chu LM, Liu Y, Feng J, Sellke FW.

J Thorac Cardiovasc Surg. 2012 Dec;144(6):1486-93. doi: 10.1016/j.jtcvs.2012.08.065. Epub 2012 Sep 17.


Chronic hypoxia attenuates VEGF signaling and angiogenic responses by downregulation of KDR in human endothelial cells.

Olszewska-Pazdrak B, Hein TW, Olszewska P, Carney DH.

Am J Physiol Cell Physiol. 2009 May;296(5):C1162-70. doi: 10.1152/ajpcell.00533.2008. Epub 2009 Feb 25.


Inhibition of the cardiac angiogenic response to surgical FGF-2 therapy in a Swine endothelial dysfunction model.

Ruel M, Wu GF, Khan TA, Voisine P, Bianchi C, Li J, Li J, Laham RJ, Sellke FW.

Circulation. 2003 Sep 9;108 Suppl 1:II335-40.


Chronic ethanol exposure stimulates endothelial cell nitric oxide production through PI-3 kinase-and hsp90-dependent mechanisms.

Polikandriotis JA, Rupnow HL, Hart CM.

Alcohol Clin Exp Res. 2005 Nov;29(11):1932-8.


Role of nitric oxide-producing and -degrading pathways in coronary endothelial dysfunction in chronic kidney disease.

Tatematsu S, Wakino S, Kanda T, Homma K, Yoshioka K, Hasegawa K, Sugano N, Kimoto M, Saruta T, Hayashi K.

J Am Soc Nephrol. 2007 Mar;18(3):741-9. Epub 2007 Jan 31.


Thrombin fragment (TP508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury.

Osipov RM, Bianchi C, Clements RT, Feng J, Liu Y, Xu SH, Robich MP, Wagstaff J, Sellke FW.

Ann Thorac Surg. 2009 Mar;87(3):786-93. doi: 10.1016/j.athoracsur.2008.12.021.


Endothelium-mediated relaxation of porcine collateral-dependent arterioles is improved by exercise training.

Griffin KL, Woodman CR, Price EM, Laughlin MH, Parker JL.

Circulation. 2001 Sep 18;104(12):1393-8.


Thrombin peptide TP508 stimulates rapid nitric oxide production in human endothelial cells.

Olszewska-Pazdrak B, Hart-Vantassell A, Carney DH.

J Vasc Res. 2010;47(3):203-13. doi: 10.1159/000255963. Epub 2009 Nov 6.


Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs.

Versari D, Daghini E, Rodriguez-Porcel M, Sattler K, Galili O, Pilarczyk K, Napoli C, Lerman LO, Lerman A.

Hypertension. 2006 Mar;47(3):475-81. Epub 2006 Jan 30.


Systemic administration of thrombin peptide TP508 enhances VEGF-stimulated angiogenesis and attenuates effects of chronic hypoxia.

Olszewska-Pazdrak B, Carney DH.

J Vasc Res. 2013;50(3):186-96. doi: 10.1159/000348250. Epub 2013 Apr 16.


Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome.

Bratz IN, Dick GM, Tune JD, Edwards JM, Neeb ZP, Dincer UD, Sturek M.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2489-96. doi: 10.1152/ajpheart.01191.2007. Epub 2008 Apr 4.

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