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Results: 1 to 20 of 207

1.

A paracrine requirement for hedgehog signalling in cancer.

Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, Marshall D, Fu L, Januario T, Kallop D, Nannini-Pepe M, Kotkow K, Marsters JC, Rubin LL, de Sauvage FJ.

Nature. 2008 Sep 18;455(7211):406-10. doi: 10.1038/nature07275. Epub 2008 Aug 27.

PMID:
18754008
[PubMed - indexed for MEDLINE]
2.

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis.

Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, de Sauvage FJ.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4254-9. doi: 10.1073/pnas.0813203106. Epub 2009 Feb 25.

PMID:
19246386
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours.

Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy PA.

Nature. 2003 Oct 23;425(6960):846-51. Epub 2003 Sep 14.

PMID:
14520411
[PubMed - indexed for MEDLINE]
4.

Paracrine Hedgehog signaling in cancer.

Theunissen JW, de Sauvage FJ.

Cancer Res. 2009 Aug 1;69(15):6007-10. doi: 10.1158/0008-5472.CAN-09-0756. Epub 2009 Jul 28. Review.

PMID:
19638582
[PubMed - indexed for MEDLINE]
Free Article
5.

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.

Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N.

Proc Natl Acad Sci U S A. 2008 Mar 25;105(12):4838-43. doi: 10.1073/pnas.0712216105. Epub 2008 Mar 21.

PMID:
18359851
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer.

Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB.

Nature. 2003 Mar 20;422(6929):313-7. Epub 2003 Mar 5.

PMID:
12629553
[PubMed - indexed for MEDLINE]
7.

Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Ruiz i Altaba A.

Cancer Cell. 2008 Oct 7;14(4):281-3. doi: 10.1016/j.ccr.2008.09.007.

PMID:
18835029
[PubMed - indexed for MEDLINE]
Free Article
8.

Cancer: Hedgehog's other great trick.

Curran T, Ng JM.

Nature. 2008 Sep 18;455(7211):293-4. doi: 10.1038/455293a. No abstract available.

PMID:
18800119
[PubMed - indexed for MEDLINE]
9.

TAK-441, a novel investigational smoothened antagonist, delays castration-resistant progression in prostate cancer by disrupting paracrine hedgehog signaling.

Ibuki N, Ghaffari M, Pandey M, Iu I, Fazli L, Kashiwagi M, Tojo H, Nakanishi O, Gleave ME, Cox ME.

Int J Cancer. 2013 Oct 15;133(8):1955-66. doi: 10.1002/ijc.28193. Epub 2013 May 6.

PMID:
23564295
[PubMed - indexed for MEDLINE]
10.

Reduced level of smoothened suppresses intestinal tumorigenesis by down-regulation of Wnt signaling.

Arimura S, Matsunaga A, Kitamura T, Aoki K, Aoki M, Taketo MM.

Gastroenterology. 2009 Aug;137(2):629-38. doi: 10.1053/j.gastro.2009.04.059. Epub 2009 May 7.

PMID:
19427313
[PubMed - indexed for MEDLINE]
11.

Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia.

Oniscu A, James RM, Morris RG, Bader S, Malcomson RD, Harrison DJ.

J Pathol. 2004 Aug;203(4):909-17.

PMID:
15258993
[PubMed - indexed for MEDLINE]
12.

Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis.

Sicklick JK, Li YX, Jayaraman A, Kannangai R, Qi Y, Vivekanandan P, Ludlow JW, Owzar K, Chen W, Torbenson MS, Diehl AM.

Carcinogenesis. 2006 Apr;27(4):748-57. Epub 2005 Dec 8.

PMID:
16339184
[PubMed - indexed for MEDLINE]
Free Article
13.

Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling.

Ruel L, Gallet A, Raisin S, Truchi A, Staccini-Lavenant L, Cervantes A, Thérond PP.

Development. 2007 Oct;134(20):3677-89. Epub 2007 Sep 19.

PMID:
17881487
[PubMed - indexed for MEDLINE]
Free Article
14.

Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells.

Chen W, Tang T, Eastham-Anderson J, Dunlap D, Alicke B, Nannini M, Gould S, Yauch R, Modrusan Z, DuPree KJ, Darbonne WC, Plowman G, de Sauvage FJ, Callahan CA.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9589-94. doi: 10.1073/pnas.1017945108. Epub 2011 May 19.

PMID:
21597001
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Clinical experience with Hedgehog pathway inhibitors.

Low JA, de Sauvage FJ.

J Clin Oncol. 2010 Dec 20;28(36):5321-6. doi: 10.1200/JCO.2010.27.9943. Epub 2010 Nov 1.

PMID:
21041712
[PubMed - indexed for MEDLINE]
Free Article
16.

Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer.

Hwang RF, Moore TT, Hattersley MM, Scarpitti M, Yang B, Devereaux E, Ramachandran V, Arumugam T, Ji B, Logsdon CD, Brown JL, Godin R.

Mol Cancer Res. 2012 Sep;10(9):1147-57. Epub 2012 Aug 2.

PMID:
22859707
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Hedgehog signaling pathway is inactive in colorectal cancer cell lines.

Chatel G, Ganeff C, Boussif N, Delacroix L, Briquet A, Nolens G, Winkler R.

Int J Cancer. 2007 Dec 15;121(12):2622-7.

PMID:
17683069
[PubMed - indexed for MEDLINE]
18.

Hedgehog signalling in prostate regeneration, neoplasia and metastasis.

Karhadkar SS, Bova GS, Abdallah N, Dhara S, Gardner D, Maitra A, Isaacs JT, Berman DM, Beachy PA.

Nature. 2004 Oct 7;431(7009):707-12. Epub 2004 Sep 12.

PMID:
15361885
[PubMed - indexed for MEDLINE]
19.

Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

Jia J, Tong C, Wang B, Luo L, Jiang J.

Nature. 2004 Dec 23;432(7020):1045-50.

PMID:
15616566
[PubMed - indexed for MEDLINE]
20.

The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway.

Malpel S, Claret S, Sanial M, Brigui A, Piolot T, Daviet L, Martin-Lannerée S, Plessis A.

Dev Biol. 2007 Mar 1;303(1):121-33. Epub 2006 Nov 3.

PMID:
17182028
[PubMed - indexed for MEDLINE]
Free Article

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