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Items: 1 to 20 of 166

1.

A parasite cysteine protease is key to host protein degradation and iron acquisition.

O'Brien TC, Mackey ZB, Fetter RD, Choe Y, O'Donoghue AJ, Zhou M, Craik CS, Caffrey CR, McKerrow JH.

J Biol Chem. 2008 Oct 24;283(43):28934-43. doi: 10.1074/jbc.M805824200. Epub 2008 Aug 13.

2.

A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.

Mackey ZB, O'Brien TC, Greenbaum DC, Blank RB, McKerrow JH.

J Biol Chem. 2004 Nov 12;279(46):48426-33. Epub 2004 Aug 23.

3.

Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.

Kerr ID, Wu P, Marion-Tsukamaki R, Mackey ZB, Brinen LS.

PLoS Negl Trop Dis. 2010 Jun 8;4(6):e701. doi: 10.1371/journal.pntd.0000701.

4.

Crystal structure of the parasite protease inhibitor chagasin in complex with a host target cysteine protease.

Ljunggren A, Redzynia I, Alvarez-Fernandez M, Abrahamson M, Mort JS, Krupa JC, Jaskolski M, Bujacz G.

J Mol Biol. 2007 Aug 3;371(1):137-53. Epub 2007 May 10.

PMID:
17561110
5.

Trypanosoma brucei: chemical evidence that cathepsin L is essential for survival and a relevant drug target.

Steverding D, Sexton DW, Wang X, Gehrke SS, Wagner GK, Caffrey CR.

Int J Parasitol. 2012 May 1;42(5):481-8. doi: 10.1016/j.ijpara.2012.03.009. Epub 2012 Apr 24.

PMID:
22549023
6.

The Inhibition of Cysteine Proteases Rhodesain and TbCatB: a Valuable Approach to Treat Human African Trypanosomiasis.

Ettari R, Previti S, Tamborini L, Cullia G, Grasso S, Zappalà M.

Mini Rev Med Chem. 2016 May 9. [Epub ahead of print]

PMID:
27156518
7.

Rab4 is an essential regulator of lysosomal trafficking in trypanosomes.

Hall BS, Pal A, Goulding D, Field MC.

J Biol Chem. 2004 Oct 22;279(43):45047-56. Epub 2004 Jul 28.

8.

Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.

Engel JC, Torres C, Hsieh I, Doyle PS, McKerrow JH.

J Cell Sci. 2000 Apr;113 ( Pt 8):1345-54. Erratum in: J Cell Sci 2000 Jul;113(Pt 14):2638. Garcia CT [corrected to Torres C].

9.

RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.

Abdulla MH, O'Brien T, Mackey ZB, Sajid M, Grab DJ, McKerrow JH.

PLoS Negl Trop Dis. 2008 Sep 24;2(9):e298. doi: 10.1371/journal.pntd.0000298.

10.
11.

Structure-guided development of selective TbcatB inhibitors.

Mallari JP, Shelat AA, Kosinski A, Caffrey CR, Connelly M, Zhu F, McKerrow JH, Guy RK.

J Med Chem. 2009 Oct 22;52(20):6489-93. doi: 10.1021/jm900908p.

12.

Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.

Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL 2nd, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH.

Mol Biochem Parasitol. 2001 Nov;118(1):61-73.

PMID:
11704274
13.

Cysteine protease inhibitors as chemotherapy for parasitic infections.

McKerrow JH, Engel JC, Caffrey CR.

Bioorg Med Chem. 1999 Apr;7(4):639-44. Review.

PMID:
10353643
14.

A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite.

Delcroix M, Sajid M, Caffrey CR, Lim KC, Dvorák J, Hsieh I, Bahgat M, Dissous C, McKerrow JH.

J Biol Chem. 2006 Dec 22;281(51):39316-29. Epub 2006 Oct 6.

15.

Cysteine proteases of parasitic organisms.

Sajid M, McKerrow JH.

Mol Biochem Parasitol. 2002 Mar;120(1):1-21. Review. Erratum in: Mol Biochem Parasitol 2002 Apr 30;121(1):159.

PMID:
11849701
16.

Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.

Mallari JP, Zhu F, Lemoff A, Kaiser M, Lu M, Brun R, Guy RK.

Bioorg Med Chem. 2010 Dec 1;18(23):8302-9. doi: 10.1016/j.bmc.2010.09.073. Epub 2010 Oct 8.

PMID:
21051236
17.

Crystal structure of the parasite inhibitor chagasin in complex with papain allows identification of structural requirements for broad reactivity and specificity determinants for target proteases.

Redzynia I, Ljunggren A, Bujacz A, Abrahamson M, Jaskolski M, Bujacz G.

FEBS J. 2009 Feb;276(3):793-806. doi: 10.1111/j.1742-4658.2008.06824.x.

18.

Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells.

Santos CC, Sant'anna C, Terres A, Cunha-e-Silva NL, Scharfstein J, de A Lima AP.

J Cell Sci. 2005 Mar 1;118(Pt 5):901-15. Epub 2005 Feb 15.

19.

Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin.

Salmon D, do Aido-Machado R, Diehl A, Leidert M, Schmetzer O, de A Lima AP, Scharfstein J, Oschkinat H, Pires JR.

J Mol Biol. 2006 Apr 14;357(5):1511-21. Epub 2006 Feb 3.

PMID:
16490204
20.

Lysosomal trafficking and cysteine protease metabolism confer target-specific cytotoxicity by peptide-linked anti-CD30-auristatin conjugates.

Sutherland MS, Sanderson RJ, Gordon KA, Andreyka J, Cerveny CG, Yu C, Lewis TS, Meyer DL, Zabinski RF, Doronina SO, Senter PD, Law CL, Wahl AF.

J Biol Chem. 2006 Apr 14;281(15):10540-7. Epub 2006 Feb 16.

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