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Results: 1 to 20 of 397

1.

Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.

Jiang H, Schiffer E, Song Z, Wang J, Zürbig P, Thedieck K, Moes S, Bantel H, Saal N, Jantos J, Brecht M, Jenö P, Hall MN, Hager K, Manns MP, Hecker H, Ganser A, Döhner K, Bartke A, Meissner C, Mischak H, Ju Z, Rudolph KL.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11299-304. doi: 10.1073/pnas.0801457105. Epub 2008 Aug 11.

PMID:
18695223
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?

Nalapareddy K, Jiang H, Guachalla Gutierrez LM, Rudolph KL.

Exp Gerontol. 2008 Nov;43(11):998-1004. doi: 10.1016/j.exger.2008.09.002. Epub 2008 Sep 11. Review.

PMID:
18817864
[PubMed - indexed for MEDLINE]
3.

Role of telomere dysfunction in aging and its detection by biomarkers.

von Figura G, Hartmann D, Song Z, Rudolph KL.

J Mol Med (Berl). 2009 Dec;87(12):1165-71. doi: 10.1007/s00109-009-0509-5. Epub 2009 Aug 8. Review.

PMID:
19669107
[PubMed - indexed for MEDLINE]
4.

Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status.

Song Z, Ju Z, Rudolph KL.

Exp Gerontol. 2009 Jan-Feb;44(1-2):75-82. doi: 10.1016/j.exger.2008.06.009. Epub 2008 Jul 3. Review.

PMID:
18640258
[PubMed - indexed for MEDLINE]
5.

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.

Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C, Trumpp A, Rudolph KL.

Nat Med. 2007 Jun;13(6):742-7. Epub 2007 May 7.

PMID:
17486088
[PubMed - indexed for MEDLINE]
6.

Diminished telomeric 3' overhangs are associated with telomere dysfunction in Hoyeraal-Hreidarsson syndrome.

Lamm N, Ordan E, Shponkin R, Richler C, Aker M, Tzfati Y.

PLoS One. 2009 May 22;4(5):e5666. doi: 10.1371/journal.pone.0005666.

PMID:
19461895
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Telomerase activity in normal leukocytes and in hematologic malignancies.

Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S.

Blood. 1995 May 1;85(9):2315-20.

PMID:
7727765
[PubMed - indexed for MEDLINE]
Free Article
8.

Telomeres and telomerase in aging, regeneration and cancer.

Djojosubroto MW, Choi YS, Lee HW, Rudolph KL.

Mol Cells. 2003 Apr 30;15(2):164-75. Review. Erratum in: Mol Cells. 2003 Aug 31;16(1):142.

PMID:
12803478
[PubMed - indexed for MEDLINE]
Free Article
9.

CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells.

Nalapareddy K, Choudhury AR, Gompf A, Ju Z, Ravipati S, Leucht T, Lechel A, Rudolph KL.

EMBO Rep. 2010 Aug;11(8):619-25. doi: 10.1038/embor.2010.83. Epub 2010 Jun 25.

PMID:
20577265
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

ELISA for aging biomarkers induced by telomere dysfunction in human plasma.

Jiang H, Chen W, Qu L, Chen Y, He Q, Wang H, Wu J, Shou Z, Ju Z, Chen J.

J Biomed Biotechnol. 2010;2010:121947. doi: 10.1155/2010/121947. Epub 2010 Nov 25.

PMID:
21127712
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.

von Figura G, Wagner M, Nalapareddy K, Hartmann D, Kleger A, Guachalla LM, Rolyan H, Adler G, Rudolph KL.

PLoS One. 2011 Feb 22;6(2):e17122. doi: 10.1371/journal.pone.0017122.

PMID:
21364961
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage.

Wiemann SU, Satyanarayana A, Buer J, Kamino K, Manns MP, Rudolph KL.

Oncogene. 2005 Feb 24;24(9):1501-9.

PMID:
15608677
[PubMed - indexed for MEDLINE]
13.

Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood.

Song Z, von Figura G, Liu Y, Kraus JM, Torrice C, Dillon P, Rudolph-Watabe M, Ju Z, Kestler HA, Sanoff H, Lenhard Rudolph K.

Aging Cell. 2010 Aug;9(4):607-15. doi: 10.1111/j.1474-9726.2010.00583.x. Epub 2010 Jun 17.

PMID:
20560902
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Telomerase therapeutics for degenerative diseases.

Harley CB.

Curr Mol Med. 2005 Mar;5(2):205-11. Review.

PMID:
15974874
[PubMed - indexed for MEDLINE]
15.

Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.

Guachalla LM, Ju Z, Koziel R, von Figura G, Song Z, Fusser M, Epe B, Jansen-Durr P, Rudolph KL.

Aging (Albany NY). 2009 Mar 5;1(3):303-15.

PMID:
20195488
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The role of telomerase expression and telomere length maintenance in human and mouse.

Weng NP, Hodes RJ.

J Clin Immunol. 2000 Jul;20(4):257-67. Review.

PMID:
10939713
[PubMed - indexed for MEDLINE]
17.

Activation of the DNA damage response by telomere attrition: a passage to cellular senescence.

Reaper PM, di Fagagna Fd, Jackson SP.

Cell Cycle. 2004 May;3(5):543-6. Epub 2004 May 8.

PMID:
15034298
[PubMed - indexed for MEDLINE]
Free Article
18.

Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease.

Satoh M, Ishikawa Y, Takahashi Y, Itoh T, Minami Y, Nakamura M.

Atherosclerosis. 2008 Jun;198(2):347-53. Epub 2007 Nov 5.

PMID:
17983621
[PubMed - indexed for MEDLINE]
19.

Telomere uncapping during in vitro T-lymphocyte senescence.

Chebel A, Bauwens S, Gerland LM, Belleville A, Urbanowicz I, de Climens AR, Tourneur Y, Chien WW, Catallo R, Salles G, Gilson E, Ffrench M.

Aging Cell. 2009 Feb;8(1):52-64. doi: 10.1111/j.1474-9726.2008.00448.x. Epub 2008 Dec 11.

PMID:
19077045
[PubMed - indexed for MEDLINE]
Free Article
20.

Telomere shortening and oxidative stress in aged macrophages results in impaired STAT5a phosphorylation.

Sebastián C, Herrero C, Serra M, Lloberas J, Blasco MA, Celada A.

J Immunol. 2009 Aug 15;183(4):2356-64. doi: 10.4049/jimmunol.0901131. Epub 2009 Jul 15.

PMID:
19605693
[PubMed - indexed for MEDLINE]
Free Article

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