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Disulfide cross-links reveal conserved features of DNA topoisomerase I architecture and a role for the N terminus in clamp closure.

Palle K, Pattarello L, van der Merwe M, Losasso C, Benedetti P, Bjornsti MA.

J Biol Chem. 2008 Oct 10;283(41):27767-75. doi: 10.1074/jbc.M804826200. Epub 2008 Aug 8.


Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

Woo MH, Losasso C, Guo H, Pattarello L, Benedetti P, Bjornsti MA.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13767-72. Epub 2003 Oct 29.


Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality.

Losasso C, Cretaio E, Palle K, Pattarello L, Bjornsti MA, Benedetti P.

J Biol Chem. 2007 Mar 30;282(13):9855-64. Epub 2007 Feb 2.


Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins.

Alessandri M, Beretta GL, Ferretti E, Mancia A, Khobta A, Capranico G.

J Mol Biol. 2004 Mar 19;337(2):295-305.


Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.

Laco GS, Collins JR, Luke BT, Kroth H, Sayer JM, Jerina DM, Pommier Y.

Biochemistry. 2002 Feb 5;41(5):1428-35.


Disulfide bond structure and domain organization of yeast beta(1,3)-glucanosyltransferases involved in cell wall biogenesis.

Popolo L, Ragni E, Carotti C, Palomares O, Aardema R, Back JW, Dekker HL, de Koning LJ, de Jong L, de Koster CG.

J Biol Chem. 2008 Jul 4;283(27):18553-65. doi: 10.1074/jbc.M801562200. Epub 2008 May 9.


Defects in SUMO (small ubiquitin-related modifier) conjugation and deconjugation alter cell sensitivity to DNA topoisomerase I-induced DNA damage.

Jacquiau HR, van Waardenburg RC, Reid RJ, Woo MH, Guo H, Johnson ES, Bjornsti MA.

J Biol Chem. 2005 Jun 24;280(25):23566-75. Epub 2005 Apr 6.


Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani.

Díaz González R, Pérez Pertejo Y, Redondo CM, Pommier Y, Balaña-Fouce R, Reguera RM.

Biochimie. 2007 Dec;89(12):1517-27. Epub 2007 Jul 31.


Mechanisms of DNA topoisomerase I-induced cell killing in the yeast Saccharomyces cerevisiae.

Fiorani P, Bjornsti MA.

Ann N Y Acad Sci. 2000;922:65-75. Review.


Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants.

Knab AM, Fertala J, Bjornsti MA.

J Biol Chem. 1993 Oct 25;268(30):22322-30.


Residues within the N-terminal domain of human topoisomerase I play a direct role in relaxation.

Lisby M, Olesen JR, Skouboe C, Krogh BO, Straub T, Boege F, Velmurugan S, Martensen PM, Andersen AH, Jayaram M, Westergaard O, Knudsen BR.

J Biol Chem. 2001 Jun 8;276(23):20220-7. Epub 2001 Mar 29.


Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505.

Montaudon D, Palle K, Rivory LP, Robert J, Douat-Casassus C, Quideau S, Bjornsti MA, Pourquier P.

J Biol Chem. 2007 May 11;282(19):14403-12. Epub 2007 Mar 12.


Human DNA topoisomerase IB: structure and functions.

Cretaio E, Pattarello L, Fontebasso Y, Benedetti P, Losasso C.

Ital J Biochem. 2007 Jun;56(2):91-102. Review.


Tethering a type IB topoisomerase to a DNA site by enzyme fusion to a heterologous site-selective DNA-binding protein domain.

Beretta GL, Binaschi M, Zagni E, Capuani L, Capranico G.

Cancer Res. 1999 Aug 1;59(15):3689-97.


DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin.

Wright CM, van der Merwe M, DeBrot AH, Bjornsti MA.

J Biol Chem. 2015 May 8;290(19):12068-78. doi: 10.1074/jbc.M114.635078. Epub 2015 Mar 20.


Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

Fiorani P, Amatruda JF, Silvestri A, Butler RH, Bjornsti MA, Benedetti P.

Mol Pharmacol. 1999 Dec;56(6):1105-15.


Identification of an N-terminal domain of eukaryotic DNA topoisomerase I dispensable for catalytic activity but essential for in vivo function.

Alsner J, Svejstrup JQ, Kjeldsen E, Sørensen BS, Westergaard O.

J Biol Chem. 1992 Jun 25;267(18):12408-11.


Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA.

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO.

Nucleic Acids Res. 2009 Oct;37(19):6414-28. doi: 10.1093/nar/gkp708. Epub 2009 Aug 31.

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