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Results: 1 to 20 of 81

1.

The role of Dickkopf-1 in bone development, homeostasis, and disease.

Pinzone JJ, Hall BM, Thudi NK, Vonau M, Qiang YW, Rosol TJ, Shaughnessy JD Jr.

Blood. 2009 Jan 15;113(3):517-25. doi: 10.1182/blood-2008-03-145169. Epub 2008 Aug 7. Review.

PMID:
18687985
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Structure-based mutation analysis shows the importance of LRP5 beta-propeller 1 in modulating Dkk1-mediated inhibition of Wnt signaling.

Bhat BM, Allen KM, Liu W, Graham J, Morales A, Anisowicz A, Lam HS, McCauley C, Coleburn V, Cain M, Fortier E, Bhat RA, Bex FJ, Yaworsky PJ.

Gene. 2007 Apr 15;391(1-2):103-12. Epub 2006 Dec 29.

PMID:
17276019
[PubMed - indexed for MEDLINE]
3.

Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia.

Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, Morony S, Adamu S, Geng Z, Qiu W, Kostenuik P, Lacey DL, Simonet WS, Bolon B, Qian X, Shalhoub V, Ominsky MS, Zhu Ke H, Li X, Richards WG.

Bone. 2006 Oct;39(4):754-66. Epub 2006 May 26.

PMID:
16730481
[PubMed - indexed for MEDLINE]
4.

Inhibiting Dickkopf-1 (Dkk1) removes suppression of bone formation and prevents the development of osteolytic bone disease in multiple myeloma.

Heath DJ, Chantry AD, Buckle CH, Coulton L, Shaughnessy JD Jr, Evans HR, Snowden JA, Stover DR, Vanderkerken K, Croucher PI.

J Bone Miner Res. 2009 Mar;24(3):425-36. doi: 10.1359/jbmr.081104.

PMID:
19016584
[PubMed - indexed for MEDLINE]
5.

Low-density lipoprotein receptor-related protein 5 (LRP5) mediates the prostate cancer-induced formation of new bone.

Li ZG, Yang J, Vazquez ES, Rose D, Vakar-Lopez F, Mathew P, Lopez A, Logothetis CJ, Lin SH, Navone NM.

Oncogene. 2008 Jan 24;27(5):596-603. Epub 2007 Aug 13.

PMID:
17700537
[PubMed - indexed for MEDLINE]
6.

Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.

Morvan F, Boulukos K, Clément-Lacroix P, Roman Roman S, Suc-Royer I, Vayssière B, Ammann P, Martin P, Pinho S, Pognonec P, Mollat P, Niehrs C, Baron R, Rawadi G.

J Bone Miner Res. 2006 Jun;21(6):934-45.

PMID:
16753024
[PubMed - indexed for MEDLINE]
7.

Bone mass is inversely proportional to Dkk1 levels in mice.

MacDonald BT, Joiner DM, Oyserman SM, Sharma P, Goldstein SA, He X, Hauschka PV.

Bone. 2007 Sep;41(3):331-9. Epub 2007 Jun 5.

PMID:
17613296
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma.

Qiang YW, Chen Y, Stephens O, Brown N, Chen B, Epstein J, Barlogie B, Shaughnessy JD Jr.

Blood. 2008 Jul 1;112(1):196-207. doi: 10.1182/blood-2008-01-132134. Epub 2008 Feb 27.

PMID:
18305214
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The binding between sclerostin and LRP5 is altered by DKK1 and by high-bone mass LRP5 mutations.

Balemans W, Piters E, Cleiren E, Ai M, Van Wesenbeeck L, Warman ML, Van Hul W.

Calcif Tissue Int. 2008 Jun;82(6):445-53. doi: 10.1007/s00223-008-9130-9.

PMID:
18521528
[PubMed - indexed for MEDLINE]
10.

The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma.

Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B, Shaughnessy JD Jr.

N Engl J Med. 2003 Dec 25;349(26):2483-94.

PMID:
14695408
[PubMed - indexed for MEDLINE]
Free Article
11.

Wnt signaling and the regulation of bone mass.

Baron R, Rawadi G.

Curr Osteoporos Rep. 2007 Jun;5(2):73-80.

PMID:
17521509
[PubMed - indexed for MEDLINE]
12.

A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).

Murrills RJ, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV.

J Cell Biochem. 2009 Dec 1;108(5):1066-75. doi: 10.1002/jcb.22335.

PMID:
19746449
[PubMed - indexed for MEDLINE]
13.

Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen.

Cselenyi CS, Lee E.

Sci Signal. 2008 Feb 26;1(8):pe10. doi: 10.1126/stke.18pe10.

PMID:
18314504
[PubMed - indexed for MEDLINE]
14.
15.

Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).

Yamaguchi Y, Morita A, Maeda A, Hearing VJ.

J Investig Dermatol Symp Proc. 2009 Aug;14(1):73-5. doi: 10.1038/jidsymp.2009.4. Review.

PMID:
19675559
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Dickkopf-1: a suitable target for the management of myeloma bone disease.

Gavriatopoulou M, Dimopoulos MA, Christoulas D, Migkou M, Iakovaki M, Gkotzamanidou M, Terpos E.

Expert Opin Ther Targets. 2009 Jul;13(7):839-48. doi: 10.1517/14728220903025770. Review.

PMID:
19530987
[PubMed - indexed for MEDLINE]
17.

Potential role for therapies targeting DKK1, LRP5, and serotonin in the treatment of osteoporosis.

Zhang W, Drake MT.

Curr Osteoporos Rep. 2012 Mar;10(1):93-100. doi: 10.1007/s11914-011-0086-8. Review.

PMID:
22210558
[PubMed - indexed for MEDLINE]
18.

A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma.

Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA.

Stem Cells. 2006 Apr;24(4):986-91. Epub 2005 Nov 17.

PMID:
16293576
[PubMed - indexed for MEDLINE]
Free Article
19.

Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway.

Knobloch J, Shaughnessy JD Jr, Rüther U.

FASEB J. 2007 May;21(7):1410-21. Epub 2007 Feb 5.

PMID:
17283219
[PubMed - indexed for MEDLINE]
Free Article
20.

Function and biological roles of the Dickkopf family of Wnt modulators.

Niehrs C.

Oncogene. 2006 Dec 4;25(57):7469-81. Review.

PMID:
17143291
[PubMed - indexed for MEDLINE]
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