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Epac signaling is required for hippocampus-dependent memory retrieval.

Ouyang M, Zhang L, Zhu JJ, Schwede F, Thomas SA.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11993-7. doi: 10.1073/pnas.0804172105. Epub 2008 Aug 7.


Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor.

Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL.

J Cell Biol. 2003 Feb 17;160(4):487-93. Epub 2003 Feb 10.


Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation.

Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, Cheng X.

J Biol Chem. 2002 Mar 29;277(13):11497-504. Epub 2002 Jan 18.


Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells.

Garay J, D'Angelo JA, Park Y, Summa CM, Aiken ML, Morales E, Badizadegan K, Fiebiger E, Dickinson BL.

J Immunol. 2010 Sep 15;185(6):3227-38. doi: 10.4049/jimmunol.0903066. Epub 2010 Aug 20.


The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.

Zhang L, Ouyang M, Ganellin CR, Thomas SA.

J Neurosci. 2013 Mar 13;33(11):5006-16. doi: 10.1523/JNEUROSCI.3834-12.2013.


Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.

Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ.

Mol Cell Biol. 2006 Mar;26(6):2130-45.


Exchange protein activated by cyclic AMP 2 (Epac2) plays a specific and time-limited role in memory retrieval.

Ostroveanu A, van der Zee EA, Eisel UL, Schmidt M, Nijholt IM.

Hippocampus. 2010 Sep;20(9):1018-26. doi: 10.1002/hipo.20700.


Cyclic AMP (cAMP)-mediated stimulation of adipocyte differentiation requires the synergistic action of Epac- and cAMP-dependent protein kinase-dependent processes.

Petersen RK, Madsen L, Pedersen LM, Hallenborg P, Hagland H, Viste K, Døskeland SO, Kristiansen K.

Mol Cell Biol. 2008 Jun;28(11):3804-16. doi: 10.1128/MCB.00709-07. Epub 2008 Apr 7.


Xamoterol impairs hippocampus-dependent emotional memory retrieval via Gi/o-coupled β2-adrenergic signaling.

Schutsky K, Ouyang M, Thomas SA.

Learn Mem. 2011 Aug 30;18(9):598-604. doi: 10.1101/lm.2302811. Print 2011.


Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.

Schutsky K, Ouyang M, Castelino CB, Zhang L, Thomas SA.

J Neurosci. 2011 Oct 5;31(40):14172-81. doi: 10.1523/JNEUROSCI.2122-11.2011.


A novel Epac-Rap-PP2A signaling module controls cAMP-dependent Akt regulation.

Hong K, Lou L, Gupta S, Ribeiro-Neto F, Altschuler DL.

J Biol Chem. 2008 Aug 22;283(34):23129-38. doi: 10.1074/jbc.M800478200. Epub 2008 Jun 12.


Epac and PKA: a tale of two intracellular cAMP receptors.

Cheng X, Ji Z, Tsalkova T, Mei F.

Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):651-62. Review.


Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo.

Efetova M, Petereit L, Rosiewicz K, Overend G, Haußig F, Hovemann BT, Cabrero P, Dow JA, Schwärzel M.

J Cell Sci. 2013 Feb 1;126(Pt 3):778-88. doi: 10.1242/jcs.114140. Epub 2012 Dec 21.


A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiation.

Shi GX, Rehmann H, Andres DA.

Mol Cell Biol. 2006 Dec;26(23):9136-47. Epub 2006 Sep 25.


Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP.

de Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, Bos JL.

Nature. 1998 Dec 3;396(6710):474-7.


EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

Huston E, Lynch MJ, Mohamed A, Collins DM, Hill EV, MacLeod R, Krause E, Baillie GS, Houslay MD.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12791-6. doi: 10.1073/pnas.0805167105. Epub 2008 Aug 26.


Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A.

Ma N, Abel T, Hernandez PJ.

Learn Mem. 2009 May 23;16(6):367-70. doi: 10.1101/lm.1231009. Print 2009 Jun.


Epac activation converts cAMP from a proliferative into a differentiation signal in PC12 cells.

Kiermayer S, Biondi RM, Imig J, Plotz G, Haupenthal J, Zeuzem S, Piiper A.

Mol Biol Cell. 2005 Dec;16(12):5639-48. Epub 2005 Oct 5.


Selective inhibition of cytokine-activated extracellular signal-regulated kinase by cyclic AMP via Epac1-dependent induction of suppressor of cytokine signalling-3.

Woolson HD, Thomson VS, Rutherford C, Yarwood SJ, Palmer TM.

Cell Signal. 2009 Nov;21(11):1706-15. doi: 10.1016/j.cellsig.2009.07.009. Epub 2009 Jul 24.

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