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Results: 1 to 20 of 111

1.

Mdm2 induces mono-ubiquitination of FOXO4.

Brenkman AB, de Keizer PL, van den Broek NJ, Jochemsen AG, Burgering BM.

PLoS One. 2008 Jul 30;3(7):e2819. doi: 10.1371/journal.pone.0002819.

PMID:
18665269
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation.

Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, Pledger JW, Chen J, Bai W.

J Biol Chem. 2009 May 22;284(21):13987-4000. doi: 10.1074/jbc.M901758200. Epub 2009 Mar 25.

PMID:
19321440
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Regulation of FOXO protein stability via ubiquitination and proteasome degradation.

Huang H, Tindall DJ.

Biochim Biophys Acta. 2011 Nov;1813(11):1961-4. doi: 10.1016/j.bbamcr.2011.01.007. Epub 2011 Jan 14. Review.

PMID:
21238503
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The human T-cell leukemia virus type 1 oncoprotein tax controls forkhead box O4 activity through degradation by the proteasome.

Oteiza A, Mechti N.

J Virol. 2011 Jul;85(13):6480-91. doi: 10.1128/JVI.00036-11. Epub 2011 Apr 27.

PMID:
21525355
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The peptidyl-isomerase Pin1 regulates p27kip1 expression through inhibition of Forkhead box O tumor suppressors.

Brenkman AB, de Keizer PL, van den Broek NJ, van der Groep P, van Diest PJ, van der Horst A, Smits AM, Burgering BM.

Cancer Res. 2008 Sep 15;68(18):7597-605. doi: 10.1158/0008-5472.CAN-08-1059.

PMID:
18794148
[PubMed - indexed for MEDLINE]
Free Article
6.

Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

Nie J, Xie P, Liu L, Xing G, Chang Z, Yin Y, Tian C, He F, Zhang L.

J Biol Chem. 2010 Jul 23;285(30):22818-30. doi: 10.1074/jbc.M110.126920. Epub 2010 May 18.

PMID:
20484049
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

UBE4B, a ubiquitin chain assembly factor, is required for MDM2-mediated p53 polyubiquitination and degradation.

Wu H, Leng RP.

Cell Cycle. 2011 Jun 15;10(12):1912-5. Epub 2011 Jun 15. Review.

PMID:
21558803
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice.

Jung CR, Lim JH, Choi Y, Kim DG, Kang KJ, Noh SM, Im DS.

J Clin Invest. 2010 Dec;120(12):4493-506. doi: 10.1172/JCI42674. Epub 2010 Nov 8.

PMID:
21060154
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

p53 regulation: teamwork between RING domains of Mdm2 and MdmX.

Wang X.

Cell Cycle. 2011 Dec 15;10(24):4225-9. doi: 10.4161/cc.10.24.18662. Epub 2011 Dec 15. Review.

PMID:
22134240
[PubMed - indexed for MEDLINE]
10.

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.

van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM.

Nat Cell Biol. 2006 Oct;8(10):1064-73. Epub 2006 Sep 10.

PMID:
16964248
[PubMed - indexed for MEDLINE]
11.

Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle.

Milkiewicz M, Roudier E, Doyle JL, Trifonova A, Birot O, Haas TL.

Am J Pathol. 2011 Feb;178(2):935-44. doi: 10.1016/j.ajpath.2010.10.042.

PMID:
21281824
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Dual-site regulation of MDM2 E3-ubiquitin ligase activity.

Wallace M, Worrall E, Pettersson S, Hupp TR, Ball KL.

Mol Cell. 2006 Jul 21;23(2):251-63.

PMID:
16857591
[PubMed - indexed for MEDLINE]
Free Article
13.

Oxidative stress-dependent regulation of Forkhead box O4 activity by nemo-like kinase.

Szypowska AA, de Ruiter H, Meijer LA, Smits LM, Burgering BM.

Antioxid Redox Signal. 2011 Feb 15;14(4):563-78. doi: 10.1089/ars.2010.3243. Epub 2010 Nov 23.

PMID:
20874444
[PubMed - indexed for MEDLINE]
14.

Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop.

Zhang X, Wang W, Wang H, Wang MH, Xu W, Zhang R.

Oncogene. 2013 May 30;32(22):2782-91. doi: 10.1038/onc.2012.289. Epub 2012 Jul 9.

PMID:
22777350
[PubMed - indexed for MEDLINE]
15.

Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells.

Qiu W, Wu J, Walsh EM, Zhang Y, Chen CY, Fujita J, Xiao ZX.

Oncogene. 2008 Jul 3;27(29):4034-43. doi: 10.1038/onc.2008.43. Epub 2008 Mar 10.

PMID:
18332869
[PubMed - indexed for MEDLINE]
16.

TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.

Bae S, Jung JH, Kim K, An IS, Kim SY, Lee JH, Park IC, Jin YW, Lee SJ, An S.

FEBS Lett. 2012 Sep 21;586(19):3057-63. doi: 10.1016/j.febslet.2012.07.022. Epub 2012 Jul 20.

PMID:
22819825
[PubMed - indexed for MEDLINE]
Free Article
17.

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.

Saville MK, Sparks A, Xirodimas DP, Wardrop J, Stevenson LF, Bourdon JC, Woods YL, Lane DP.

J Biol Chem. 2004 Oct 1;279(40):42169-81. Epub 2004 Jul 26.

PMID:
15280377
[PubMed - indexed for MEDLINE]
Free Article
18.

Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors.

Roy SK, Chen Q, Fu J, Shankar S, Srivastava RK.

PLoS One. 2011;6(9):e25166. doi: 10.1371/journal.pone.0025166. Epub 2011 Sep 27.

PMID:
21980390
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.

Lee HR, Toth Z, Shin YC, Lee JS, Chang H, Gu W, Oh TK, Kim MH, Jung JU.

J Virol. 2009 Jul;83(13):6739-47. doi: 10.1128/JVI.02353-08. Epub 2009 Apr 15.

PMID:
19369353
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Stabilization of p53 in influenza A virus-infected cells is associated with compromised MDM2-mediated ubiquitination of p53.

Wang X, Deng X, Yan W, Zhu Z, Shen Y, Qiu Y, Shi Z, Shao D, Wei J, Xia X, Ma Z.

J Biol Chem. 2012 May 25;287(22):18366-75. doi: 10.1074/jbc.M111.335422. Epub 2012 Apr 3.

PMID:
22474335
[PubMed - indexed for MEDLINE]
Free PMC Article
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