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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

Goodarzi AA, Noon AT, Deckbar D, Ziv Y, Shiloh Y, Löbrich M, Jeggo PA.

Mol Cell. 2008 Jul 25;31(2):167-77. doi: 10.1016/j.molcel.2008.05.017.


The impact of heterochromatin on DSB repair.

Goodarzi AA, Noon AT, Jeggo PA.

Biochem Soc Trans. 2009 Jun;37(Pt 3):569-76. doi: 10.1042/BST0370569.


53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.

Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA.

Nat Cell Biol. 2010 Feb;12(2):177-84. doi: 10.1038/ncb2017. Epub 2010 Jan 17.


The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Goodarzi AA, Jeggo P, Lobrich M.

DNA Repair (Amst). 2010 Dec 10;9(12):1273-82. doi: 10.1016/j.dnarep.2010.09.013. Epub 2010 Oct 30. Review.


Analysis of human syndromes with disordered chromatin reveals the impact of heterochromatin on the efficacy of ATM-dependent G2/M checkpoint arrest.

Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A.

Mol Cell Biol. 2011 Oct;31(19):4022-35. doi: 10.1128/MCB.05289-11. Epub 2011 Jul 26.


Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair.

Woodbine L, Brunton H, Goodarzi AA, Shibata A, Jeggo PA.

Nucleic Acids Res. 2011 Sep 1;39(16):6986-97. doi: 10.1093/nar/gkr331. Epub 2011 May 19.


The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation.

White D, Rafalska-Metcalf IU, Ivanov AV, Corsinotti A, Peng H, Lee SC, Trono D, Janicki SM, Rauscher FJ 3rd.

Mol Cancer Res. 2012 Mar;10(3):401-14. doi: 10.1158/1541-7786.MCR-11-0134. Epub 2011 Dec 28.


ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M.

EMBO J. 2009 Nov 4;28(21):3413-27. doi: 10.1038/emboj.2009.276. Epub 2009 Sep 24.


KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

Goodarzi AA, Kurka T, Jeggo PA.

Nat Struct Mol Biol. 2011 Jun 5;18(7):831-9. doi: 10.1038/nsmb.2077.


DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin.

Jakob B, Splinter J, Conrad S, Voss KO, Zink D, Durante M, Löbrich M, Taucher-Scholz G.

Nucleic Acids Res. 2011 Aug;39(15):6489-99. doi: 10.1093/nar/gkr230. Epub 2011 Apr 21.


DNA double-strand break repair within heterochromatic regions.

Murray JM, Stiff T, Jeggo PA.

Biochem Soc Trans. 2012 Feb;40(1):173-8. doi: 10.1042/BST20110631. Review.


Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks.

Tomimatsu N, Tahimic CG, Otsuki A, Burma S, Fukuhara A, Sato K, Shiota G, Oshimura M, Chen DJ, Kurimasa A.

J Biol Chem. 2007 Apr 6;282(14):10138-45. Epub 2007 Feb 1.


ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.

Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.

Nature. 2011 Jan 13;469(7329):250-4. doi: 10.1038/nature09604. Epub 2010 Dec 15.


Beyond repair foci: DNA double-strand break repair in euchromatic and heterochromatic compartments analyzed by transmission electron microscopy.

Lorat Y, Schanz S, Schuler N, Wennemuth G, Rübe C, Rübe CE.

PLoS One. 2012;7(5):e38165. doi: 10.1371/journal.pone.0038165. Epub 2012 May 30.


Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation.

Xue L, Yu D, Furusawa Y, Okayasu R, Tong J, Cao J, Fan S.

Mutat Res. 2009 Nov 2;670(1-2):15-23. doi: 10.1016/j.mrfmmm.2009.06.016. Epub 2009 Jul 5.


Three-dimensional cell growth confers radioresistance by chromatin density modification.

Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, Schröck E, Cordes N.

Cancer Res. 2010 May 15;70(10):3925-34. doi: 10.1158/0008-5472.CAN-09-3848. Epub 2010 May 4.


Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks.

Ismail IH, Nyström S, Nygren J, Hammarsten O.

J Biol Chem. 2005 Feb 11;280(6):4649-55. Epub 2004 Nov 15.


Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair.

Klement K, Luijsterburg MS, Pinder JB, Cena CS, Del Nero V, Wintersinger CM, Dellaire G, van Attikum H, Goodarzi AA.

J Cell Biol. 2014 Dec 22;207(6):717-33. doi: 10.1083/jcb.201405077.


Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.

Rass E, Chandramouly G, Zha S, Alt FW, Xie A.

J Biol Chem. 2013 Mar 8;288(10):7086-95. doi: 10.1074/jbc.M112.445825. Epub 2013 Jan 26.


NBN phosphorylation regulates the accumulation of MRN and ATM at sites of DNA double-strand breaks.

Wen J, Cerosaletti K, Schultz KJ, Wright JA, Concannon P.

Oncogene. 2013 Sep 12;32(37):4448-56. doi: 10.1038/onc.2012.443. Epub 2012 Nov 12.

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