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Results: 1 to 20 of 114

Similar articles for PubMed (Select 18651728)

1.

Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.

Sirisoma N, Kasibhatla S, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Baichwal V, Mather GG, Jessing K, Hussain R, Hoang K, Pleiman CM, Tseng B, Drewe J, Cai SX.

J Med Chem. 2008 Aug 14;51(15):4771-9. doi: 10.1021/jm8003653. Epub 2008 Jul 24.

PMID:
18651728
2.

Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.

Sirisoma N, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Mather G, Pleiman CM, Kasibhatla S, Tseng B, Drewe J, Cai SX.

J Med Chem. 2009 Apr 23;52(8):2341-51. doi: 10.1021/jm801315b.

PMID:
19296653
3.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Crogan-Grundy C, Labreque D, Bubenick M, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2008 Feb 14;51(3):417-23. doi: 10.1021/jm7010657. Epub 2008 Jan 16.

PMID:
18197614
4.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Wang Y, Zhao J, Jia S, Herich J, Labreque D, Storer R, Meerovitch K, Bouffard D, Rej R, Denis R, Blais C, Lamothe S, Attardo G, Gourdeau H, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2004 Dec 2;47(25):6299-310.

PMID:
15566300
5.

Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring.

Sirisoma N, Pervin A, Zhang H, Jiang S, Adam Willardsen J, Anderson MB, Mather G, Pleiman CM, Kasibhatla S, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2330-4. doi: 10.1016/j.bmcl.2010.01.155. Epub 2010 Feb 4.

PMID:
20188546
6.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions.

Kemnitzer W, Drewe J, Jiang S, Zhang H, Zhao J, Crogan-Grundy C, Xu L, Lamothe S, Gourdeau H, Denis R, Tseng B, Kasibhatla S, Cai SX.

J Med Chem. 2007 Jun 14;50(12):2858-64. Epub 2007 May 11.

PMID:
17497765
7.

Discovery and mechanism of action of a novel series of apoptosis inducers with potential vascular targeting activity.

Kasibhatla S, Gourdeau H, Meerovitch K, Drewe J, Reddy S, Qiu L, Zhang H, Bergeron F, Bouffard D, Yang Q, Herich J, Lamothe S, Cai SX, Tseng B.

Mol Cancer Ther. 2004 Nov;3(11):1365-74.

8.

Discovery of substituted N-phenyl nicotinamides as potent inducers of apoptosis using a cell- and caspase-based high throughput screening assay.

Cai SX, Nguyen B, Jia S, Herich J, Guastella J, Reddy S, Tseng B, Drewe J, Kasibhatla S.

J Med Chem. 2003 Jun 5;46(12):2474-81.

PMID:
12773051
9.

Discovery and SAR of indole-2-carboxylic acid benzylidene-hydrazides as a new series of potent apoptosis inducers using a cell-based HTS assay.

Zhang HZ, Drewe J, Tseng B, Kasibhatla S, Cai SX.

Bioorg Med Chem. 2004 Jul 1;12(13):3649-55.

PMID:
15186849
10.

Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers.

Kemnitzer W, Sirisoma N, May C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3536-40. doi: 10.1016/j.bmcl.2009.04.145. Epub 2009 May 5.

PMID:
19464890
11.

MPC-6827: a small-molecule inhibitor of microtubule formation that is not a substrate for multidrug resistance pumps.

Kasibhatla S, Baichwal V, Cai SX, Roth B, Skvortsova I, Skvortsov S, Lukas P, English NM, Sirisoma N, Drewe J, Pervin A, Tseng B, Carlson RO, Pleiman CM.

Cancer Res. 2007 Jun 15;67(12):5865-71.

12.

Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay.

Jiang S, Crogan-Grundy C, Drewe J, Tseng B, Cai SX.

Bioorg Med Chem Lett. 2008 Nov 1;18(21):5725-8. doi: 10.1016/j.bmcl.2008.09.088. Epub 2008 Sep 27.

PMID:
18849165
13.

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.

Sirisoma N, Kasibhatla S, Nguyen B, Pervin A, Wang Y, Claassen G, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2006 Dec 1;14(23):7761-73. Epub 2006 Aug 21.

PMID:
16919962
14.

Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions.

Kemnitzer W, Kasibhatla S, Jiang S, Zhang H, Zhao J, Jia S, Xu L, Crogan-Grundy C, Denis R, Barriault N, Vaillancourt L, Charron S, Dodd J, Attardo G, Labrecque D, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4745-51.

PMID:
16143530
15.

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions.

Kemnitzer W, Kuemmerle J, Jiang S, Zhang HZ, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6259-64. doi: 10.1016/j.bmcl.2008.09.110. Epub 2008 Oct 17.

PMID:
18952423
16.

Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.

Kemnitzer W, Jiang S, Zhang H, Kasibhatla S, Crogan-Grundy C, Blais C, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5571-5. doi: 10.1016/j.bmcl.2008.09.011. Epub 2008 Sep 6. Erratum in: Bioorg Med Chem Lett. 2009 Jan 15;19(2):554.

PMID:
18805007
17.

Discovery of 5-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-7-phenyl-(E)-2,3,6,7-tetrahydro-1,4-thiazepines as a new series of apoptosis inducers using a cell- and caspase-based HTS assay.

Drewe J, Kasibhatla S, Tseng B, Shelton E, Sperandio D, Yee RM, Litvak J, Sendzik M, Spencer JR, Cai SX.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4987-90. Epub 2007 Jun 6.

PMID:
17562361
18.

Discovery and structure-activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers.

Zhang HZ, Claassen G, Crogran-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem. 2008 Jan 1;16(1):222-31. Epub 2007 Oct 4.

PMID:
17950608
19.

Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions.

Kemnitzer W, Kuemmerle J, Jiang S, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3481-4. doi: 10.1016/j.bmcl.2009.05.012. Epub 2009 May 8.

PMID:
19467598
20.

Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group.

Kemnitzer W, Sirisoma N, Nguyen B, Jiang S, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):3045-9. doi: 10.1016/j.bmcl.2009.04.009. Epub 2009 Apr 8.

PMID:
19394823
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