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Items: 1 to 20 of 176


GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells.

Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A.

J Biol Chem. 2008 Oct 3;283(40):27208-19. doi: 10.1074/jbc.M804282200. Epub 2008 Jul 23.


Selective regulation of the perinuclear distribution of glucose transporter 4 (GLUT4) by insulin signals in muscle cells.

Dugani CB, Randhawa VK, Cheng AW, Patel N, Klip A.

Eur J Cell Biol. 2008 Jun;87(6):337-51. doi: 10.1016/j.ejcb.2008.02.009. Epub 2008 Apr 15.


Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.

Ishikura S, Bilan PJ, Klip A.

Biochem Biophys Res Commun. 2007 Feb 23;353(4):1074-9. Epub 2006 Dec 27.


Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.

Ishikura S, Klip A.

Am J Physiol Cell Physiol. 2008 Oct;295(4):C1016-25. doi: 10.1152/ajpcell.00277.2008. Epub 2008 Aug 13.


Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes.

Brewer PD, Romenskaia I, Kanow MA, Mastick CC.

J Biol Chem. 2011 Jul 29;286(30):26287-97. doi: 10.1074/jbc.M111.253880. Epub 2011 May 24.


Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking.

Larance M, Ramm G, Stöckli J, van Dam EM, Winata S, Wasinger V, Simpson F, Graham M, Junutula JR, Guilhaus M, James DE.

J Biol Chem. 2005 Nov 11;280(45):37803-13. Epub 2005 Sep 8.


Small G proteins in insulin action: Rab and Rho families at the crossroads of signal transduction and GLUT4 vesicle traffic.

Ishikura S, Koshkina A, Klip A.

Acta Physiol (Oxf). 2008 Jan;192(1):61-74. doi: 10.1111/j.1748-1716.2007.01778.x. Review.


Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.

Sun Y, Bilan PJ, Liu Z, Klip A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19909-14. doi: 10.1073/pnas.1009523107. Epub 2010 Nov 1.


A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.

Ramm G, Larance M, Guilhaus M, James DE.

J Biol Chem. 2006 Sep 29;281(39):29174-80. Epub 2006 Jul 31.


Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.

Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE.

Cell Metab. 2007 Apr;5(4):293-303.


Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.

Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.

Diabetes. 2008 May;57(5):1195-204. doi: 10.2337/db07-1469. Epub 2008 Feb 14.


Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.

Sun Y, Chiu TT, Foley KP, Bilan PJ, Klip A.

Mol Biol Cell. 2014 Apr;25(7):1159-70. doi: 10.1091/mbc.E13-08-0493. Epub 2014 Jan 29.


Insulin-induced actin filament remodeling colocalizes actin with phosphatidylinositol 3-kinase and GLUT4 in L6 myotubes.

Khayat ZA, Tong P, Yaworsky K, Bloch RJ, Klip A.

J Cell Sci. 2000 Jan;113 Pt 2:279-90.


Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts.

Török D, Patel N, Jebailey L, Thong FS, Randhawa VK, Klip A, Rudich A.

J Cell Sci. 2004 Oct 15;117(Pt 22):5447-55. Epub 2004 Oct 5.


The Rab GTPase-activating protein AS160 as a common regulator of insulin- and Galphaq-mediated intracellular GLUT4 vesicle distribution.

Yuasa T, Uchiyama K, Ogura Y, Kimura M, Teshigawara K, Hosaka T, Tanaka Y, Obata T, Sano H, Kishi K, Ebina Y.

Endocr J. 2009;56(3):345-59. Epub 2009 Jan 9.


Hyperosmolarity reduces GLUT4 endocytosis and increases its exocytosis from a VAMP2-independent pool in l6 muscle cells.

Li D, Randhawa VK, Patel N, Hayashi M, Klip A.

J Biol Chem. 2001 Jun 22;276(25):22883-91. Epub 2001 Apr 10.


Insulin sensitivity and inhibition by forskolin, dipyridamole and pentobarbital of glucose transport in three L6 muscle cell lines.

Niu W, Bilan PJ, Hayashi M, Da Y, Yao Z.

Sci China C Life Sci. 2007 Dec;50(6):739-47. Epub 2007 Sep 20.


Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.

Samovski D, Su X, Xu Y, Abumrad NA, Stahl PD.

J Lipid Res. 2012 Apr;53(4):709-17. doi: 10.1194/jlr.M023424. Epub 2012 Feb 6.

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