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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R.

Cell Metab. 2008 Aug;8(2):157-68. doi: 10.1016/j.cmet.2008.06.011. Epub 2008 Jul 3.


Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans.

Greer EL, Brunet A.

Aging Cell. 2009 Apr;8(2):113-27. doi: 10.1111/j.1474-9726.2009.00459.x. Epub 2009 Feb 23.


Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span.

Marchal J, Pifferi F, Aujard F.

Ann N Y Acad Sci. 2013 Jul;1290:67-73. doi: 10.1111/nyas.12214. Review.


A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice.

Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA.

PLoS One. 2008 Jun 4;3(6):e2264. doi: 10.1371/journal.pone.0002264. Erratum in: PLoS ONE. 2008;3(6). doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/8333176c-b08c-4dfb-a829-6331c0fc6064. PLoS ONE. 2008;3(6). doi: 10.1371/annotation/7d56e94e-3582-413d-b987-fccd0da79081.


Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart.

Barger JL, Kayo T, Pugh TD, Prolla TA, Weindruch R.

Exp Gerontol. 2008 Sep;43(9):859-66. doi: 10.1016/j.exger.2008.06.013. Epub 2008 Jul 9.


Resveratrol protects against age-associated infertility in mice.

Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L.

Hum Reprod. 2013 Mar;28(3):707-17. doi: 10.1093/humrep/des437. Epub 2013 Jan 4.


Resveratrol and life extension.

Agarwal B, Baur JA.

Ann N Y Acad Sci. 2011 Jan;1215:138-43. doi: 10.1111/j.1749-6632.2010.05850.x. Review.


Resveratrol and rapamycin: are they anti-aging drugs?

Kaeberlein M.

Bioessays. 2010 Feb;32(2):96-9. doi: 10.1002/bies.200900171.


The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster.

Wang C, Wheeler CT, Alberico T, Sun X, Seeberger J, Laslo M, Spangler E, Kern B, de Cabo R, Zou S.

Age (Dordr). 2013 Feb;35(1):69-81. doi: 10.1007/s11357-011-9332-3. Epub 2011 Nov 16.


Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans.

Smith ED, Kaeberlein TL, Lydum BT, Sager J, Welton KL, Kennedy BK, Kaeberlein M.

BMC Dev Biol. 2008 May 5;8:49. doi: 10.1186/1471-213X-8-49.


The prolongevity effect of resveratrol depends on dietary composition and calorie intake in a tephritid fruit fly.

Zou S, Carey JR, Liedo P, Ingram DK, Müller HG, Wang JL, Yao F, Yu B, Zhou A.

Exp Gerontol. 2009 Jun-Jul;44(6-7):472-6. doi: 10.1016/j.exger.2009.02.011. Epub 2009 Mar 3.


Diet and aging.

Piper MD, Bartke A.

Cell Metab. 2008 Aug;8(2):99-104. doi: 10.1016/j.cmet.2008.06.012. Review.


The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice.

Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA.

Free Radic Biol Med. 2004 Apr 15;36(8):1043-57.


Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.

Kane AE, Hilmer SN, Boyer D, Gavin K, Nines D, Howlett SE, de Cabo R, Mitchell SJ.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):333-9. doi: 10.1093/gerona/glu315. Epub 2015 Feb 22.


Caloric restriction, resveratrol and melatonin: Role of SIRT1 and implications for aging and related-diseases.

Ramis MR, Esteban S, Miralles A, Tan DX, Reiter RJ.

Mech Ageing Dev. 2015 Mar;146-148:28-41. doi: 10.1016/j.mad.2015.03.008. Epub 2015 Mar 27. Review.


Resveratrol Attenuates Oxidative Stress and Extends Life Span in the Annual Fish Nothobranchius guentheri.

Liu T, Qi H, Ma L, Liu Z, Fu H, Zhu W, Song T, Yang B, Li G.

Rejuvenation Res. 2015 Jun;18(3):225-33. doi: 10.1089/rej.2014.1618. Epub 2015 May 20.


Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet-induced obesity.

Wang B, Sun J, Li X, Zhou Q, Bai J, Shi Y, Le G.

Nutr Res. 2013 Nov;33(11):971-81. doi: 10.1016/j.nutres.2013.07.016. Epub 2013 Aug 27.


The effect of long-term dietary supplementation with antioxidants.

Meydani M, Lipman RD, Han SN, Wu D, Beharka A, Martin KR, Bronson R, Cao G, Smith D, Meydani SN.

Ann N Y Acad Sci. 1998 Nov 20;854:352-60. Review.


Evolution of human longevity uncoupled from caloric restriction mechanisms.

Zhao G, Guo S, Somel M, Khaitovich P.

PLoS One. 2014 Jan 6;9(1):e84117. doi: 10.1371/journal.pone.0084117. eCollection 2014.

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