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Results: 1 to 20 of 428

1.

An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors.

Toh SM, Mankin AS.

J Mol Biol. 2008 Jul 18;380(4):593-7. doi: 10.1016/j.jmb.2008.05.027. Epub 2008 May 17.

PMID:
18554609
[PubMed - indexed for MEDLINE]
2.

UV-induced modifications in the peptidyl transferase loop of 23S rRNA dependent on binding of the streptogramin B antibiotic, pristinamycin IA.

Porse BT, Kirillov SV, Awayez MJ, Garrett RA.

RNA. 1999 Apr;5(4):585-95.

PMID:
10199574
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

A sparsomycin-resistant mutant of Halobacterium salinarium lacks a modification at nucleotide U2603 in the peptidyl transferase centre of 23 S rRNA.

Lázaro E, Rodriguez-Fonseca C, Porse B, Ureña D, Garrett RA, Ballesta JP.

J Mol Biol. 1996 Aug 16;261(2):231-8. Erratum in: J Mol Biol 1996 Dec 13;264(4):839.

PMID:
8757290
[PubMed - indexed for MEDLINE]
5.

Erythromycin binding is reduced in ribosomes with conformational alterations in the 23 S rRNA peptidyl transferase loop.

Douthwaite S, Aagaard C.

J Mol Biol. 1993 Aug 5;232(3):725-31.

PMID:
7689111
[PubMed - indexed for MEDLINE]
6.

Effect of antibiotics on large ribosomal subunit assembly reveals possible function of 5 S rRNA.

Khaitovich P, Mankin AS.

J Mol Biol. 1999 Sep 3;291(5):1025-34.

PMID:
10518940
[PubMed - indexed for MEDLINE]
7.

Identification of 50S components neighboring 23S rRNA nucleotides A2448 and U2604 within the peptidyl transferase center of Escherichia coli ribosomes.

Vladimirov SN, Druzina Z, Wang R, Cooperman BS.

Biochemistry. 2000 Jan 11;39(1):183-93.

PMID:
10625493
[PubMed - indexed for MEDLINE]
8.

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.

Kloss P, Xiong L, Shinabarger DL, Mankin AS.

J Mol Biol. 1999 Nov 19;294(1):93-101.

PMID:
10556031
[PubMed - indexed for MEDLINE]
9.

Inhibition of the ribosomal peptidyl transferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin.

Poulsen SM, Kofoed C, Vester B.

J Mol Biol. 2000 Dec 1;304(3):471-81.

PMID:
11090288
[PubMed - indexed for MEDLINE]
10.

Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

Xiong L, Kloss P, Douthwaite S, Andersen NM, Swaney S, Shinabarger DL, Mankin AS.

J Bacteriol. 2000 Oct;182(19):5325-31.

PMID:
10986233
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

The structure of helix 89 of 23S rRNA is important for peptidyl transferase function of Escherichia coli ribosome.

Burakovsky DE, Sergiev PV, Steblyanko MA, Konevega AL, Bogdanov AA, Dontsova OA.

FEBS Lett. 2011 Oct 3;585(19):3073-8. doi: 10.1016/j.febslet.2011.08.030. Epub 2011 Aug 27.

PMID:
21875584
[PubMed - indexed for MEDLINE]
Free Article
12.

Implications of a functional large ribosomal RNA with only three modified nucleotides.

Sirum-Connolly K, Peltier JM, Crain PF, McCloskey JA, Mason TL.

Biochimie. 1995;77(1-2):30-9.

PMID:
7541254
[PubMed - indexed for MEDLINE]
13.

23S rRNA nucleotides in the peptidyl transferase center are essential for tryptophanase operon induction.

Yang R, Cruz-Vera LR, Yanofsky C.

J Bacteriol. 2009 Jun;191(11):3445-50. doi: 10.1128/JB.00096-09. Epub 2009 Mar 27.

PMID:
19329641
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable.

O'Connor M, Lee WM, Mankad A, Squires CL, Dahlberg AE.

Nucleic Acids Res. 2001 Feb 1;29(3):710-5.

PMID:
11160893
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mutations at nucleotides G2251 and U2585 of 23 S rRNA perturb the peptidyl transferase center of the ribosome.

Green R, Samaha RR, Noller HF.

J Mol Biol. 1997 Feb 14;266(1):40-50.

PMID:
9054969
[PubMed - indexed for MEDLINE]
16.

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.

Xiong L, Shah S, Mauvais P, Mankin AS.

Mol Microbiol. 1999 Jan;31(2):633-9.

PMID:
10027979
[PubMed - indexed for MEDLINE]
17.

Efficient ribosomal peptidyl transfer critically relies on the presence of the ribose 2'-OH at A2451 of 23S rRNA.

Erlacher MD, Lang K, Wotzel B, Rieder R, Micura R, Polacek N.

J Am Chem Soc. 2006 Apr 5;128(13):4453-9.

PMID:
16569023
[PubMed - indexed for MEDLINE]
18.

Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide.

Cruz-Vera LR, Gong M, Yanofsky C.

Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3598-603. Epub 2006 Feb 27.

PMID:
16505360
[PubMed - indexed for MEDLINE]
Free PMC Article
19.
20.

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.

Polacek N, Gaynor M, Yassin A, Mankin AS.

Nature. 2001 May 24;411(6836):498-501.

PMID:
11373685
[PubMed - indexed for MEDLINE]
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