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Results: 1 to 20 of 725

1.

Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives.

Ryckebusch A, Garcin D, Lansiaux A, Goossens JF, Baldeyrou B, Houssin R, Bailly C, Hénichart JP.

J Med Chem. 2008 Jun 26;51(12):3617-29. doi: 10.1021/jm800017u. Epub 2008 May 29.

PMID:
18507368
[PubMed - indexed for MEDLINE]
2.

Indeno[1,2-c]isoquinolin-5,11-diones conjugated to amino acids: Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties.

Ahn G, Lansiaux A, Goossens JF, Bailly C, Baldeyrou B, Schifano-Faux N, Grandclaudon P, Couture A, Ryckebusch A.

Bioorg Med Chem. 2010 Nov 15;18(22):8119-33. doi: 10.1016/j.bmc.2010.08.025. Epub 2010 Aug 16.

PMID:
20961767
[PubMed - indexed for MEDLINE]
3.

Synthesis, cytotoxicity and topoisomerase inhibition properties of multifarious aminoalkylated indeno[1,2-c]isoquinolin-5,11-diones.

Ahn G, Schifano-Faux N, Goossens JF, Baldeyrou B, Couture A, Grandclaudon P, Lansiaux A, Ryckebusch A.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2259-63. doi: 10.1016/j.bmcl.2011.02.106. Epub 2011 Mar 1.

PMID:
21439821
[PubMed - indexed for MEDLINE]
4.

Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.

Tseng CH, Tzeng CC, Yang CL, Lu PJ, Chen HL, Li HY, Chuang YC, Yang CN, Chen YL.

J Med Chem. 2010 Aug 26;53(16):6164-79. doi: 10.1021/jm1005447.

PMID:
20662543
[PubMed - indexed for MEDLINE]
5.

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

Tardy C, Facompré M, Laine W, Baldeyrou B, García-Gravalos D, Francesch A, Mateo C, Pastor A, Jiménez JA, Manzanares I, Cuevas C, Bailly C.

Bioorg Med Chem. 2004 Apr 1;12(7):1697-712.

PMID:
15028262
[PubMed - indexed for MEDLINE]
6.

Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.

Cushman M, Jayaraman M, Vroman JA, Fukunaga AK, Fox BM, Kohlhagen G, Strumberg D, Pommier Y.

J Med Chem. 2000 Oct 5;43(20):3688-98.

PMID:
11020283
[PubMed - indexed for MEDLINE]
7.

Synthesis of substituted indeno[1,2-b]quinoline-6-carboxamides, [1]benzothieno[3,2-b]quinoline-4-carboxamides and 10H-quindoline-4-carboxamides: evaluation of structure-activity relationships for cytotoxicity.

Chen J, Deady LW, Desneves J, Kaye AJ, Finlay GJ, Baguley BC, Denny WA.

Bioorg Med Chem. 2000 Oct;8(10):2461-6.

PMID:
11058041
[PubMed - indexed for MEDLINE]
8.

Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.

Bolognese A, Correale G, Manfra M, Lavecchia A, Mazzoni O, Novellino E, La Colla P, Sanna G, Loddo R.

J Med Chem. 2004 Feb 12;47(4):849-58.

PMID:
14761187
[PubMed - indexed for MEDLINE]
9.

Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.

Antony S, Agama KK, Miao ZH, Hollingshead M, Holbeck SL, Wright MH, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y.

Mol Pharmacol. 2006 Sep;70(3):1109-20. Epub 2006 Jun 23.

PMID:
16798938
[PubMed - indexed for MEDLINE]
Free Article
10.

Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.

Kim JS, Rhee HK, Park HJ, Lee IK, Lee SK, Suh ME, Lee HJ, Ryu CK, Choo HY.

Bioorg Med Chem. 2007 Jan 1;15(1):451-7. Epub 2006 Oct 10.

PMID:
17035025
[PubMed - indexed for MEDLINE]
11.

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.

Nagarajan M, Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M.

J Med Chem. 2003 Dec 18;46(26):5712-24.

PMID:
14667224
[PubMed - indexed for MEDLINE]
12.

Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.

Nagarajan M, Morrell A, Fort BC, Meckley MR, Antony S, Kohlhagen G, Pommier Y, Cushman M.

J Med Chem. 2004 Nov 4;47(23):5651-61.

PMID:
15509164
[PubMed - indexed for MEDLINE]
13.
14.

Design, docking, and synthesis of novel indeno[1,2-c]isoquinolines for the development of antitumor agents as topoisomerase I inhibitors.

Cho WJ, Le QM, My Van HT, Youl Lee K, Kang BY, Lee ES, Lee SK, Kwon Y.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3531-4. Epub 2007 Apr 25.

PMID:
17498951
[PubMed - indexed for MEDLINE]
15.

WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.

Hsiao CJ, Li TK, Chan YL, Hsin LW, Liao CH, Lee CH, Lyu PC, Guh JH.

Biochem Pharmacol. 2008 Feb 15;75(4):847-56. Epub 2007 Oct 22.

PMID:
18035333
[PubMed - indexed for MEDLINE]
16.

Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.

Vispé S, Vandenberghe I, Robin M, Annereau JP, Créancier L, Pique V, Galy JP, Kruczynski A, Barret JM, Bailly C.

Biochem Pharmacol. 2007 Jun 15;73(12):1863-72. Epub 2007 Mar 3.

PMID:
17391647
[PubMed - indexed for MEDLINE]
17.

Novel pyrrolo[3,2-f]quinolines: synthesis and antiproliferative activity.

Ferlin MG, Gatto B, Chiarelotto G, Palumbo M.

Bioorg Med Chem. 2001 Jul;9(7):1843-8.

PMID:
11425586
[PubMed - indexed for MEDLINE]
18.

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles.

Weinkauf RL, Chen AY, Yu C, Liu L, Barrows L, LaVoie EJ.

Bioorg Med Chem. 1994 Aug;2(8):781-6.

PMID:
7894971
[PubMed - indexed for MEDLINE]
19.

DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.

Lansiaux A, Laine W, Baldeyrou B, Mahieu C, Wattez N, Vezin H, Martinez FJ, Piñeyro A, Bailly C.

Chem Res Toxicol. 2001 Jan;14(1):16-24.

PMID:
11170504
[PubMed - indexed for MEDLINE]
20.

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.

Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3659-63.

PMID:
15203138
[PubMed - indexed for MEDLINE]

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