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Items: 1 to 20 of 110

1.

Mass spectrometry identifies covalent binding of soman, sarin, chlorpyrifos oxon, diisopropyl fluorophosphate, and FP-biotin to tyrosines on tubulin: a potential mechanism of long term toxicity by organophosphorus agents.

Grigoryan H, Schopfer LM, Thompson CM, Terry AV, Masson P, Lockridge O.

Chem Biol Interact. 2008 Sep 25;175(1-3):180-6. doi: 10.1016/j.cbi.2008.04.013. Epub 2008 Apr 22.

2.

Tyrosines of human and mouse transferrin covalently labeled by organophosphorus agents: a new motif for binding to proteins that have no active site serine.

Li B, Schopfer LM, Grigoryan H, Thompson CM, Hinrichs SH, Masson P, Lockridge O.

Toxicol Sci. 2009 Jan;107(1):144-55. doi: 10.1093/toxsci/kfn211. Epub 2008 Oct 16.

3.

Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin.

Ding SJ, Carr J, Carlson JE, Tong L, Xue W, Li Y, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O.

Chem Res Toxicol. 2008 Sep;21(9):1787-94. doi: 10.1021/tx800144z. Epub 2008 Aug 16.

4.

Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon: implications for neurotoxicity.

Grigoryan H, Lockridge O.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):143-8. doi: 10.1016/j.taap.2009.07.015. Epub 2009 Jul 22.

5.

Mass spectrometry identifies multiple organophosphorylated sites on tubulin.

Grigoryan H, Schopfer LM, Peeples ES, Duysen EG, Grigoryan M, Thompson CM, Lockridge O.

Toxicol Appl Pharmacol. 2009 Oct 15;240(2):149-58. doi: 10.1016/j.taap.2009.07.020. Epub 2009 Jul 24.

6.
7.

Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry.

Jiang W, Duysen EG, Lockridge O.

Toxicology. 2012 May 16;295(1-3):15-22. doi: 10.1016/j.tox.2012.03.001. Epub 2012 Mar 8.

PMID:
22406659
8.

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry assay for organophosphorus toxicants bound to human albumin at Tyr411.

Li B, Schopfer LM, Hinrichs SH, Masson P, Lockridge O.

Anal Biochem. 2007 Feb 15;361(2):263-72. Epub 2006 Dec 4.

9.

Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine.

Grigoryan H, Li B, Anderson EK, Xue W, Nachon F, Lockridge O, Schopfer LM.

Chem Biol Interact. 2009 Aug 14;180(3):492-8. doi: 10.1016/j.cbi.2009.03.018. Epub 2009 Apr 2.

10.

Partial characterization of an enzyme that hydrolyzes sarin, soman, tabun, and diisopropyl phosphorofluoridate (DFP).

Little JS, Broomfield CA, Fox-Talbot MK, Boucher LJ, MacIver B, Lenz DE.

Biochem Pharmacol. 1989 Jan 1;38(1):23-9.

PMID:
2910306
11.

The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin.

Davies HG, Richter RJ, Keifer M, Broomfield CA, Sowalla J, Furlong CE.

Nat Genet. 1996 Nov;14(3):334-6.

PMID:
8896566
12.

Mass spectral characterization of organophosphate-labeled, tyrosine-containing peptides: characteristic mass fragments and a new binding motif for organophosphates.

Schopfer LM, Grigoryan H, Li B, Nachon F, Masson P, Lockridge O.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 May 15;878(17-18):1297-311. doi: 10.1016/j.jchromb.2009.07.026. Epub 2009 Jul 24.

13.

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry.

Peeples ES, Schopfer LM, Duysen EG, Spaulding R, Voelker T, Thompson CM, Lockridge O.

Toxicol Sci. 2005 Feb;83(2):303-12. Epub 2004 Nov 3.

14.

Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase.

Schopfer LM, Voelker T, Bartels CF, Thompson CM, Lockridge O.

Chem Res Toxicol. 2005 Apr;18(4):747-54.

PMID:
15833035
15.

Binding of some organophosphorus compounds at adenosine receptors in guinea pig brain membranes.

Lau WM, Freeman SE, Szilagyi M.

Neurosci Lett. 1988 Nov 22;94(1-2):125-30.

PMID:
3241661
16.

Mass spectral characterization of organophosphate-labeled lysine in peptides.

Grigoryan H, Li B, Xue W, Grigoryan M, Schopfer LM, Lockridge O.

Anal Biochem. 2009 Nov 1;394(1):92-100. doi: 10.1016/j.ab.2009.07.008. Epub 2009 Jul 9.

17.

Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.

Samanta U, Kirby SD, Srinivasan P, Cerasoli DM, Bahnson BJ.

Biochem Pharmacol. 2009 Aug 15;78(4):420-9. doi: 10.1016/j.bcp.2009.04.018. Epub 2009 Apr 24.

18.

Nerve agent analogues that produce authentic soman, sarin, tabun, and cyclohexyl methylphosphonate-modified human butyrylcholinesterase.

Gilley C, MacDonald M, Nachon F, Schopfer LM, Zhang J, Cashman JR, Lockridge O.

Chem Res Toxicol. 2009 Oct;22(10):1680-8. doi: 10.1021/tx900090m.

19.

Microtubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity.

Prendergast MA, Self RL, Smith KJ, Ghayoumi L, Mullins MM, Butler TR, Buccafusco JJ, Gearhart DA, Terry AV Jr.

Neuroscience. 2007 Apr 25;146(1):330-9. Epub 2007 Feb 22.

20.

Distribution of [3H]diisopropylfluorophosphate, [3H]soman, [3H]sarin, and their metabolites in mouse brain.

Little PJ, Scimeca JA, Martin BR.

Drug Metab Dispos. 1988 Jul-Aug;16(4):515-20.

PMID:
2903016
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