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Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation.

Salvay DM, Rives CB, Zhang X, Chen F, Kaufman DB, Lowe WL Jr, Shea LD.

Transplantation. 2008 May 27;85(10):1456-64. doi: 10.1097/TP.0b013e31816fc0ea.


Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation.

Blomeier H, Zhang X, Rives C, Brissova M, Hughes E, Baker M, Powers AC, Kaufman DB, Shea LD, Lowe WL Jr.

Transplantation. 2006 Aug 27;82(4):452-9.


Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia.

Yap WT, Salvay DM, Silliman MA, Zhang X, Bannon ZG, Kaufman DB, Lowe WL Jr, Shea LD.

Tissue Eng Part A. 2013 Nov;19(21-22):2361-72. doi: 10.1089/ten.TEA.2013.0033. Epub 2013 Jun 27.


Development of an ectopic site for islet transplantation, using biodegradable scaffolds.

Dufour JM, Rajotte RV, Zimmerman M, Rezania A, Kin T, Dixon DE, Korbutt GS.

Tissue Eng. 2005 Sep-Oct;11(9-10):1323-31.


Fibroblast populated collagen matrix promotes islet survival and reduces the number of islets required for diabetes reversal.

Jalili RB, Moeen Rezakhanlou A, Hosseini-Tabatabaei A, Ao Z, Warnock GL, Ghahary A.

J Cell Physiol. 2011 Jul;226(7):1813-9. doi: 10.1002/jcp.22515.


Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice.

Gibly RF, Zhang X, Lowe WL Jr, Shea LD.

Cell Transplant. 2013;22(5):811-9.


Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models.

Gibly RF, Zhang X, Graham ML, Hering BJ, Kaufman DB, Lowe WL Jr, Shea LD.

Biomaterials. 2011 Dec;32(36):9677-84. doi: 10.1016/j.biomaterials.2011.08.084. Epub 2011 Sep 28.


Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds.

Hlavaty KA, Gibly RF, Zhang X, Rives CB, Graham JG, Lowe WL Jr, Luo X, Shea LD.

Am J Transplant. 2014 Jul;14(7):1523-32. doi: 10.1111/ajt.12742. Epub 2014 Jun 6.


Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control.

Knight KR, Uda Y, Findlay MW, Brown DL, Cronin KJ, Jamieson E, Tai T, Keramidaris E, Penington AJ, Rophael J, Harrison LC, Morrison WA.

FASEB J. 2006 Mar;20(3):565-7. Epub 2006 Jan 25. Erratum in: FASEB J. 2008 May;22(5):1618.


Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel.

Davis NE, Beenken-Rothkopf LN, Mirsoian A, Kojic N, Kaplan DL, Barron AE, Fontaine MJ.

Biomaterials. 2012 Oct;33(28):6691-7. doi: 10.1016/j.biomaterials.2012.06.015. Epub 2012 Jul 4.


Nano-scale encapsulation enhances allograft survival and function of islets transplanted in a mouse model of diabetes.

Zhi ZL, Kerby A, King AJ, Jones PM, Pickup JC.

Diabetologia. 2012 Apr;55(4):1081-90. doi: 10.1007/s00125-011-2431-y. Epub 2012 Jan 14.


Reversal of diabetes by the creation of neo-islet tissues into a subcutaneous site using islet cell sheets.

Saito T, Ohashi K, Utoh R, Shimizu H, Ise K, Suzuki H, Yamato M, Okano T, Gotoh M.

Transplantation. 2011 Dec 15;92(11):1231-6. doi: 10.1097/TP.0b013e3182375835.


Subcutaneous transplantation may not be an appropriate approach for the islets embedded in the collagen gel scaffolds.

Xu J, Miao G, Zhao Y, Wei J.

Transplant Proc. 2011 Nov;43(9):3205-8. doi: 10.1016/j.transproceed.2011.09.058.


A prevascularized tissue engineering chamber supports growth and function of islets and progenitor cells in diabetic mice.

Forster NA, Penington AJ, Hardikar AA, Palmer JA, Hussey A, Tai J, Morrison WA, Feeney SJ.

Islets. 2011 Sep-Oct;3(5):271-83. Epub 2011 Sep 1.


Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.

Kheradmand T, Wang S, Gibly RF, Zhang X, Holland S, Tasch J, Graham JG, Kaufman DB, Miller SD, Shea LD, Luo X.

Biomaterials. 2011 Jul;32(20):4517-24. doi: 10.1016/j.biomaterials.2011.03.009. Epub 2011 Apr 1.


Maintenance of islet morphology is beneficial for transplantation outcome in diabetic mice.

Rackham CL, Jones PM, King AJ.

PLoS One. 2013;8(2):e57844. doi: 10.1371/journal.pone.0057844. Epub 2013 Feb 25.


Early, but not advanced, glomerulopathy is reversed by pancreatic islet transplants in experimental diabetic rats: correlation with glomerular extracellular matrix mRNA levels.

Pugliese G, Pricci F, Pesce C, Romeo G, Lenti E, Caltabiano V, Vetri M, Purrello F, Di Mario U.

Diabetes. 1997 Jul;46(7):1198-206.


Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice.

Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GC.

Transplantation. 1998 Jul 15;66(1):21-8.


Neural crest stem cells increase beta cell proliferation and improve islet function in co-transplanted murine pancreatic islets.

Olerud J, Kanaykina N, Vasylovska S, King D, Sandberg M, Jansson L, Kozlova EN.

Diabetologia. 2009 Dec;52(12):2594-601. doi: 10.1007/s00125-009-1544-z. Epub 2009 Oct 13. Erratum in: Diabetologia. 2010 Feb;53(2):396. Vasilovska, S [corrected to Vasylovska, S].

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